White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Abstract Cannabis use disorder (CUD) is associated with adverse mental health effects, as well social and cognitive impairment. Given prevalence rates of CUD are increasing, there considerable efforts, need, to identify prognostic markers which may aid in minimising any harms this condition. Previous neuroimaging studies have revealed changes white matter (WM) organization people CUD, though, findings mixed. In study, we applied MRI-based analysis techniques that offer complimentary mechanistic insights, i.e., a connectome approach fixel-based (FBA) investigate properties individual WM fibre populations their microstructure across the entire brain, providing highly sensitive detect subtle overcome limitations previous diffusion models. We compared 56 individuals (median age 25 years) sample 38 healthy 31.5 years). Compared controls, those had significantly increased structural connectivity strength (FDR corrected) 9 edges between right parietal cortex several cortical subcortical regions, including left orbitofrontal, temporal pole, hippocampus putamen. Utilizing FBA, density was higher (FWE splenium corpus callosum, lower bilateral cingulum cerebellum. observed significant correlation cannabis over past month frontoparietal edge, regular Our enhance understanding architecture alterations CUD.

Language: Английский

---

Association Between Cannabis Use and Brain Structures: A Mendelian Randomization Study

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Background Observational studies suggested that cannabis use was associated with alternation of brain structures; however, as subjected to confounding factors, they were difficult make causal inferences and direction determinations. In this study, a two-sample Mendelian randomization (MR) analysis employed examine the potential association between structures. Methods The genome-wide (GWAS) data for lifetime (LCU), disorder (CUD), cortical subcortical structures utilized in study. Cortical divided into 34 distinct gyral-defined regions surface area (SA) thickness (TH) measured. Subcortical encompassed volumes from seven specified regions. primary estimator used our inverse-variance weighted (IVW), complemented by MR-Egger median methods enhance robustness results. Cochran's Q test, funnel plots, intercept tests detect heterogeneity pleiotropy. Results No relationship detected LCU global SA or TH. However, at regional cortex level, decreased TH fusiform (β = -0.0168 mm, SE 0.00581, P 0.0039) lateral occipital -0.0141 0.00531, 0.0079) regions, while increasing postcentral region 0.0093 0.00445, 0.0374). At found increase brainstem volume 0.224 mm3, 0.09, 0.0128). CUD did not show any structure either levels. Nonetheless, after applying multiple comparison corrections, values MR relationships these meet significance threshold. Conclusion evidence causally influencing is insufficient.

Language: Английский

---

White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 11, 2024

Abstract Cannabis use disorder (CUD) is associated with adverse mental health effects, as well social and cognitive impairment. Given prevalence rates of CUD are increasing, there considerable efforts, need, to identify prognostic markers which may aid in minimising any harm this condition. Previous neuroimaging studies have revealed changes white matter (WM) organization people CUD, though, the findings mixed. In study, we applied MRI-based analysis techniques that offer complimentary mechanistic insights, i.e., a connectome approach fixel-based (FBA) investigate properties individual WM fibre populations their microstructure across entire brain, providing highly sensitive detect subtle overcome limitations previous diffusion models. We compared 56 individuals (median age 25 years) sample 38 healthy 31.5 years). Compared controls, those had significantly increased structural connectivity strength (FDR corrected) 9 edges between right parietal cortex several cortical subcortical regions, including left orbitofrontal, temporal pole, hippocampus putamen. Utilizing FBA, density was higher (FWE-corrected) splenium corpus callosum, lower bilateral cingulum cerebellum. observed significant correlation cannabis over past month frontoparietal edge, regular Our enhance understanding architecture alterations CUD.

Language: Английский

---

Assessment of White Matter Fiber Integrity with High Angular Resolution Diffusion-Weighted Imaging

Lecture notes in electrical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 942 - 947

Published: Oct. 19, 2024

Language: Английский

---