REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Objective: Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to variability humans is not yet established. Here, we investigated if vivo activity of LC related quality Rapid Eye Movement (REM) sleep. Methods: We assessed 34 healthy younger (~22y) 18 older (~61y) individuals engaged bottom-up top-down cognitive tasks using 7-Tesla functional Magnetic Resonance Imaging (fMRI). further recorded their electroencephalogram (EEG) evaluate associations between fMRI measures REM EEG metrics. Results: Theta oscillation energy during was positively associated with response task. In contrast, theta negatively Importantly, sigma oscillations power immediately preceding a episode Interpretation: intensity transient change sleep, feature causally animal studies. The depend on task, suggesting balanced level tonic required for optimal expression findings may have implications high prevalence complaints reported aging disorders such as insomnia, Alzheimers, Parkinsons disease, which play pivotal through

Language: Английский

REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: March 11, 2025

Abstract Background Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to variability humans is not yet established. Here, we investigated if vivo activity of LC related quality Rapid Eye Movement (REM) sleep. Methods We assessed 34 healthy younger (~ 22y) 18 older 61y) individuals engaged bottom-up top-down cognitive tasks using 7-Tesla functional Magnetic Resonance Imaging (fMRI). further recorded their electroencephalogram (EEG) evaluate associations between fMRI measures REM EEG metrics. Results Theta oscillation energy during was positively associated with response task. In contrast, theta negatively Importantly, sigma oscillations power immediately preceding a episode Conclusions intensity transient change sleep, feature causally animal studies. The depend on task, suggesting balanced level tonic required for optimal expression findings may have implications high prevalence complaints reported aging disorders such as insomnia, Alzheimer’s, Parkinson’s disease, which play pivotal through

Language: Английский

Citations

1
Insomnia and REM sleep instability DOI Creative Commons
Bernd Feige, Fee Benz, Raphael J. Dressle

et al.

Journal of Sleep Research, Journal Year: 2023, Volume and Issue: 32(6)

Published: Sept. 7, 2023

Summary In this narrative review, we give an overview of the concept rapid eye movement sleep instability and its reported implications in context insomnia. The term was coined to describe observation a modified quality insomnia, characterized by increased tendency perceiving as wake, small but consistent reduction arousal index. Current research highlights relationships that are transdiagnostic nature, corresponding known interaction insomnia with many psychiatric disorders, showing chronic stress anxiety disorders.

Language: Английский

Citations

15
Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy DOI Creative Commons
Alexandre Berger, Elise Beckers, Vincent Joris

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 13, 2024

The locus coeruleus–norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This known prevent seizure development and induce long-term plastic changes, particularly with release norepinephrine hippocampus. However, requisites become responder therapy mechanisms action are still under investigation. Using MRI, we assessed structural functional characteristics coeruleus microstructural properties coeruleus-hippocampus white matter tracts patients drug-resistant epilepsy responding or not therapy. Twenty-three epileptic cervical stimulation were recruited for this pilot study, including 13 responders partial 10 non-responders. A dedicated MRI acquisition allowed vivo localization computation its contrast (an accepted marker LC integrity). Locus activity was estimated using during an auditory oddball task. Finally, multi-shell diffusion used estimate tracts. These compared between responders/partial non-responders their association duration also explored. In a better response therapy, trends toward lower higher found left medial right caudal portions coeruleus, respectively. An increased contrast, bilaterally over portions, correlated treatment. integrity connections new insights into neurobiology may provide novel markers treatment reflect neuroplasticity occurring brain following implantation.

Language: Английский

Citations

5
Locus coeruleus activity while awake is associated with REM sleep quality in older individuals DOI Creative Commons
Ekaterina Koshmanova, Alexandre Berger, Elise Beckers

et al.

JCI Insight, Journal Year: 2023, Volume and Issue: 8(20)

Published: Sept. 12, 2023

BACKGROUNDThe locus coeruleus (LC) is the primary source of norepinephrine in brain and regulates arousal sleep. Animal research shows that it plays important roles transition between sleep wakefulness, slow wave rapid eye movement (REMS). It unclear, however, whether activity LC predicts variability humans.METHODSWe used 7-Tesla functional MRI, electroencephalography (EEG), a questionnaire to test during wakefulness was associated with quality 33 healthy younger (~22 years old; 28 women, 5 men) 19 older (~61 14 individuals.RESULTSWe found that, but not participants, higher activity, as probed an auditory attentional task, worse subjective lower power over EEG theta band REMS. The results remained robust even when accounting for age-related changes integrity LC.CONCLUSIONThese findings suggest correlates perception essential oscillatory mode REMS, we may be target treatment sleep- diseases.FUNDINGThis work supported by Fonds National de la Recherche Scientifique (FRS-FNRS, T.0242.19 & J. 0222.20), Action Concertée - Fédération Wallonie-Bruxelles (ARC SLEEPDEM 17/27-09), Fondation Alzheimer (SAO-FRA 2019/0025), ULiège, European Regional Development Fund (Radiomed Biomed-Hub).

Language: Английский

Citations

11
Exploring the Role of Locus Coeruleus in Alzheimer’s Disease: a Comprehensive Update on MRI Studies and Implications DOI Creative Commons
Alessandro Galgani, Filippo Sean Giorgi

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(12), P. 925 - 936

Published: Dec. 1, 2023

Abstract Purpose of Review Performing a thorough review magnetic resonance imaging (MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer’s disease (AD), contextualizing them with current preclinical neuropathological literature. Recent Findings MRI successfully detected LC alterations AD, identifying degenerative phenomena involving this nucleus even the prodromal stages disorder. The degree disruption was also associated severity AD cortical pathology, cognitive behavioral impairment, risk clinical progression. Summary Locus coeruleus-MRI has proved to be useful tool assess central noradrenergic system vivo humans. It allowed test patients experimental hypothesis, thus confirming specific marked involvement its key pathogenetic role. coeruleus-MRI–related data might represent theoretical basis on which start developing drugs target AD.

Language: Английский

Citations

10
A review of symptom, pathogenesis and treatment characteristics of the elderly with chronic insomnia DOI Creative Commons

LiBo Xia,

Haiyan Liu,

Jixiang Ren

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(5), P. e41346 - e41346

Published: Jan. 31, 2025

One third of a person's life is in state sleep, and good sleep quality one the indicators health. Long-term insomnia has great impact on patients' life, physical mental state. Especially elderly, long-term will induce variety chronic diseases, seriously affecting life. Because characteristics physiological structure elderly its unique different from that young. This article reviews terms symptom, pathogenesis treatment. By elaborating senile insomnia, we hope to provide ideas for clinical treatment insomnia.

Language: Английский

Citations

0
The crosstalk between the anterior hypothalamus and the locus coeruleus during wakefulness is associated with low frequency oscillations power during sleep DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Study Objectives Animal research has demonstrated that sleep regulation heavily depends on a network of subcortical nuclei. In particular, whether the crosstalk between Locus Coeruleus (LC) and hypothalamic nuclei influences variability age-related changes in humans remains unexplored. This study investigated effective connectivity LC subparts hypothalamus is associated with electrophysiology rapid eye movement (REMS). Methods Thirty-three healthy younger (∼22y, 27 women) 18 older (∼61y, 14 individuals underwent 7-Tesla functional magnetic resonance imaging during wakefulness to investigate distinct encompassing several Additionally, we recorded their electroencephalogram (EEG) explore relationships measures REMS theta energy sigma power prior episodes. Results The analysis revealed robust evidence mutual positive influence anterior-superior posterior hypothalamus, supporting idea patterns observed animal models are also present humans. Furthermore, our results suggest adults, stronger from including preoptic area, reduced REM energy. Specificity showed this association was not limited but extended specific lower-frequency bands NREMS. Conclusions These findings highlight complex age-dependent modulation circuitry its role regulation. Understanding these neural interactions offers valuable insight into mechanisms driving changes.

Language: Английский

Citations

0
Age-related Increase in Locus Coeruleus Activity and Connectivity with Prefrontal Cortex during Ambiguity Processing DOI Creative Commons

Arjun Dave,

Shuer Ye, Leona Rahel Bätz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Abstract Interpreting ambiguous environmental cues, like facial expressions, becomes increasingly challenging with age, especially as cognitive resources decline. Managing these challenges requires adaptive neural mechanisms that are essential for maintaining mental well-being. The locus coeruleus (LC), the brain’s main norepinephrine source, regulates attention, arousal, and stress response. With extensive cortical connections, LC supports adapting to demands resolving conflicting cues from environment, particularly in later life. Previous research suggests interacts prefrontal cortex during high-conflict tasks. However, whether activity its connectivity PFC support emotional ambiguity processing contributes well-being healthy aging remains unclear. To address this gap, we used 7T-MRI examine function 75 younger (25.8±4.02years, 35females) 69 older adults (71.3±4.1 years, emotion-recognition task morphed varying ambiguity: anchor (unambiguous happy or fearful), intermediate- (30% happy–70% fearful 40%-happy–60% either direction), absolute-ambiguity (50% happy-fearful). Behaviorally, participants had longer response times lower confidence condition, while perceived faces more frequently than adults. Neuroimaging results revealed exhibited greater enhanced dorsolateral (dlPFC) compared This heightened was linked better resilience These findings suggest managing cognitively demanding tasks, LC-dlPFC helps maintain well- being, underscoring importance of pathway aging. Significance Statement Understanding how brain adapts age is key promoting study examined a region critical regulating attention undergoes changes task. Using ultra-high-field imaging, explored recognize expressions levels. Our indicated young, showed LC-dorsolateral when absolute-ambiguous improved higher LC- dlPFC resilience, offering insights into underlying

Language: Английский

Citations

0
REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Objective: Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to variability humans is not yet established. Here, we investigated if vivo activity of LC related quality Rapid Eye Movement (REM) sleep. Methods: We assessed 34 healthy younger (~22y) 18 older (~61y) individuals engaged bottom-up top-down cognitive tasks using 7-Tesla functional Magnetic Resonance Imaging (fMRI). further recorded their electroencephalogram (EEG) evaluate associations between fMRI measures REM EEG metrics. Results: Theta oscillation energy during was positively associated with response task. In contrast, theta negatively Importantly, sigma oscillations power immediately preceding a episode Interpretation: intensity transient change sleep, feature causally animal studies. The depend on task, suggesting balanced level tonic required for optimal expression findings may have implications high prevalence complaints reported aging disorders such as insomnia, Alzheimers, Parkinsons disease, which play pivotal through

Language: Английский

Citations

0