European journal of medical research,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Feb. 9, 2024
Abstract
Multiple
sclerosis
(MS)
is
the
most
frequent
inflammatory
and
demyelinating
disease
of
central
nervous
system
(CNS).
The
underlying
pathophysiology
MS
destruction
myelin
sheath
by
immune
cells.
formation
plaques,
inflammation,
injury
neuronal
characterizes
its
neuropathology.
plaques
are
multiple
focal
regions
demyelination
disseminated
in
brain's
white
matter,
spinal
cords,
deep
grey
cerebral
cortex.
Fenofibrate
a
peroxisome
proliferative
activated
receptor
alpha
(PPAR-α)
that
attenuates
reactions
MS.
inhibits
differentiation
Th17
inhibiting
expression
pro-inflammatory
signaling.
According
to
these
findings,
this
review
intended
illuminate
mechanistic
immunoinflammatory
role
fenofibrate
mitigating
In
conclusion,
can
attenuate
neuropathology
modulating
different
pathways,
including
oxidative
stress,
autophagy,
mitochondrial
dysfunction,
inflammatory-signaling
neuroinflammation.
Complex Psychiatry,
Journal Year:
2023,
Volume and Issue:
9(1-4), P. 154 - 171
Published: Jan. 1, 2023
<b><i>Background:</i></b>
Lipids
are
essential
components
of
the
structure
and
for
function
brain
cells.
The
intricate
balance
lipids,
including
phospholipids,
glycolipids,
cholesterol,
cholesterol
ester,
triglycerides,
is
crucial
maintaining
normal
function.
roles
lipids
lipid
droplets
their
relevance
to
neurodegenerative
neuropsychiatric
disorders
(NPDs)
remain
largely
unknown.
<b><i>Summary:</i></b>
Here,
we
reviewed
basic
role
as
well
a
specific
organelle,
droplets,
in
function,
highlighting
potential
impact
altered
metabolism
pathogenesis
Alzheimer’s
disease
(AD)
NDPs.
<b><i>Key
Messages:</i></b>
Brain
dysregulation
plays
pivotal
progression
NPDs
AD
schizophrenia.
Understanding
cell
type-specific
mechanisms
these
diseases
identifying
better
diagnostic
biomarkers
developing
therapeutic
strategies
aiming
at
restoring
homeostasis.
Molecular and Cellular Neuroscience,
Journal Year:
2023,
Volume and Issue:
126, P. 103887 - 103887
Published: Aug. 15, 2023
Mitochondrial
dysfunction
can
arise
from
genetic
defects
or
environmental
exposures
and
impact
a
wide
range
of
biological
processes.
Among
these
are
metabolic
pathways
involved
in
glutamine
catabolism,
anabolism,
glutamine-glutamate
cycling.
In
recent
years,
altered
metabolism
has
been
found
to
play
important
roles
the
pathologic
consequences
mitochondrial
dysfunction.
Glutamine
is
pleiotropic
molecule,
not
only
providing
an
alternate
carbon
source
glucose
certain
conditions,
but
also
playing
unique
cellular
communication
neurons
astrocytes.
consumption
catabolic
flux
be
significantly
settings
exposure
toxins,
alterations
appears
particularly
significant
role
neurodegenerative
diseases.
These
include
primary
diseases
like
Leigh
syndrome
(subacute
necrotizing
encephalopathy)
MELAS
(mitochondrial
myopathy
with
encephalopathy,
lactic
acidosis,
stroke-like
episodes),
as
well
complex
age-related
disorders
such
Alzheimer's
Parkinson's
Pharmacologic
interventions
targeting
metabolizing
catabolizing
appear
provide
some
benefits
cell
animal
models
diseases,
indicating
may
clinically
relevant
target.
this
review,
we
discuss
metabolism,
disease,
on
processes,
neurodegeneration,
candidate
targets
for
therapeutic
intervention.
FEBS Letters,
Journal Year:
2024,
Volume and Issue:
598(10), P. 1215 - 1225
Published: April 11, 2024
Lipid
droplets
(LDs)
are
intracellular
organelles
with
a
hydrophobic
core
formed
by
neutral
lipids
surrounded
phospholipid
monolayer
harboring
variety
of
regulatory
and
enzymatically
active
proteins.
Over
the
last
few
decades,
our
understanding
LD
biology
has
evolved
significantly.
Nowadays,
LDs
appreciated
not
just
as
passive
energy
storage
units,
but
rather
players
in
regulation
lipid
metabolism
quality
control
machineries.
To
fulfill
their
functions
controlling
cellular
metabolic
states,
need
to
be
highly
dynamic
responsive
organelles.
A
large
body
evidence
supports
nature
proteome
its
contact
sites
other
However,
much
less
is
known
about
lipidome
LDs.
Numerous
examples
clearly
indicate
intrinsic
link
between
proteins,
calling
for
deeper
characterization
various
physiological
pathological
settings.
Here,
we
reviewed
current
state
knowledge
field
lipidome,
providing
brief
overview
classes
molecular
species
present
within
monolayer.
European journal of medical research,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Feb. 9, 2024
Abstract
Multiple
sclerosis
(MS)
is
the
most
frequent
inflammatory
and
demyelinating
disease
of
central
nervous
system
(CNS).
The
underlying
pathophysiology
MS
destruction
myelin
sheath
by
immune
cells.
formation
plaques,
inflammation,
injury
neuronal
characterizes
its
neuropathology.
plaques
are
multiple
focal
regions
demyelination
disseminated
in
brain's
white
matter,
spinal
cords,
deep
grey
cerebral
cortex.
Fenofibrate
a
peroxisome
proliferative
activated
receptor
alpha
(PPAR-α)
that
attenuates
reactions
MS.
inhibits
differentiation
Th17
inhibiting
expression
pro-inflammatory
signaling.
According
to
these
findings,
this
review
intended
illuminate
mechanistic
immunoinflammatory
role
fenofibrate
mitigating
In
conclusion,
can
attenuate
neuropathology
modulating
different
pathways,
including
oxidative
stress,
autophagy,
mitochondrial
dysfunction,
inflammatory-signaling
neuroinflammation.
