Like sisters but not twins – vasopressin and oxytocin excite BNST neurons via cell type-specific expression of oxytocin receptor to reduce anxious arousal DOI Creative Commons
Walter Francesconi,

Valentina Olivera-Pasilio,

Fulvia Berton

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Interoceptive signals dynamically interact with the environment to shape appropriate defensive behaviors. Hypothalamic hormones arginine-vasopressin (AVP) and oxytocin (OT) regulate physiological states, including water electrolyte balance, circadian rhythmicity, Both AVP OT neurons project dorsolateral bed nucleus of stria terminalis (BNSTDL), which expresses receptors (OTR) vasopressin mediates fear responses. However, understanding integrated role neurohypophysial is complicated by cross-reactivity their mutual receptor promiscuity. Here, we provide evidence that effects on BNST excitability are driven input specificity cell type-specific selectivity. We show OTR-expressing BNSTDL neurons, excited hypothalamic inputs via OTR, play a major in regulating excitability, overcoming threat avoidance, reducing threat-elicited anxious arousal. Therefore, OTR-BNSTDL perfectly suited drive dynamic interactions balancing external risk needs.

Language: Английский

The influence of oxytocin-based interventions on sleep-wake and sleep-related behaviour and neurobiology: A systematic review of preclinical and clinical studies DOI
Joel S. Raymond, Simone Rehn, Camilla M. Hoyos

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 131, P. 1005 - 1026

Published: Oct. 19, 2021

Language: Английский

Citations

14
Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala DOI Creative Commons
Walter Francesconi, Fulvia Berton,

Valentina Olivera-Pasilio

et al.

Neuropharmacology, Journal Year: 2021, Volume and Issue: 192, P. 108601 - 108601

Published: May 7, 2021

Language: Английский

Citations

13
Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams DOI Creative Commons
Steffy B. Manjila, Rebecca Betty, Yongsoo Kim

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Oct. 26, 2022

The hypothalamic neuropeptide, oxytocin (Oxt), has been the focus of research for decades due to its effects on body physiology, neural circuits, and various behaviors. Oxt elicits a multitude actions mainly through receptor, receptor (OxtR). Despite past understand central projections neurons OxtR- coupled signaling pathways in different brain areas, it remains unclear how this nonapeptide exhibits such pleiotropic while integrating external internal information. Most reviews field either neuroanatomy Oxt-OxtR system, or functional specific areas. Here, we provide review by wide connectivity their downstream circuits with OxtR expression mice. We categorize connected regions into three modules that regulate state, somatic visceral, cognitive response. Each module contains process distinct behavioral effects. Broad innervations (e.g., basal ganglia motor behavior) enable exert coordinated modulation functionally inter-connected circuits. Moreover, acts as neuromodulator neuromodulations broadly control overall state brain. Lastly, discuss mismatch between across mouse In summary, brings forth circuit-based analysis whole light release provides perspective guide future studies.

Language: Английский

Citations

8
Oxytocin modulates sensitivity to acculturation and discrimination stress in pregnancy DOI Creative Commons
Angela C. Incollingo Rodriguez, Laura Smith, Rebeca Harris

et al.

Psychoneuroendocrinology, Journal Year: 2022, Volume and Issue: 141, P. 105769 - 105769

Published: April 13, 2022

Latinas in the United States suffer disproportionately high levels of pre- and postnatal depression. However, little is understood regarding biopsychosocial mechanisms linking socio-environmental factors to this increase mental health risk. The oxytocinergic system, with its roles stress response, social behaviour mood regulation, may be an important modulator sensitivity. We have previously reported prenatal discrimination a significant predictor depression Latinas; here we tested whether sensitivity might depend on system activity.A sample 148 Latina women residing US were assessed prenatally at 24-32 weeks' gestation 46 weeks postnatally for perceived levels, acculturation, anxiety symptoms. Plasma oxytocin (OXT) DNA methylation receptor (OXTR) measured together genotyping OXTR SNP, rs53576.In mothers low OXT methylation, acculturation level was associated No such associations found those higher methylation. also relationship between psychosocial (discrimination acculturation) carriers G-allele rs53576, but not AA genotypes. Finally, positively correlated reports experiencing affiliative touch. Moreover, touch mediated methylation.These results support hypothesis that modulates development disorders mothers.

Language: Английский

Citations

7
Like sisters but not twins – vasopressin and oxytocin excite BNST neurons via cell type-specific expression of oxytocin receptor to reduce anxious arousal DOI Creative Commons
Walter Francesconi,

Valentina Olivera-Pasilio,

Fulvia Berton

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Interoceptive signals dynamically interact with the environment to shape appropriate defensive behaviors. Hypothalamic hormones arginine-vasopressin (AVP) and oxytocin (OT) regulate physiological states, including water electrolyte balance, circadian rhythmicity, Both AVP OT neurons project dorsolateral bed nucleus of stria terminalis (BNSTDL), which expresses receptors (OTR) vasopressin mediates fear responses. However, understanding integrated role neurohypophysial is complicated by cross-reactivity their mutual receptor promiscuity. Here, we provide evidence that effects on BNST excitability are driven input specificity cell type-specific selectivity. We show OTR-expressing BNSTDL neurons, excited hypothalamic inputs via OTR, play a major in regulating excitability, overcoming threat avoidance, reducing threat-elicited anxious arousal. Therefore, OTR-BNSTDL perfectly suited drive dynamic interactions balancing external risk needs.

Language: Английский

Citations

1