Association of Sleep Duration With Serum Estradiol Concentrations Among American Men and Women: Evidence From NHANES 2013–2016

International Journal of Endocrinology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objective: To evaluate the association between sleep duration with serum estradiol concentrations and its variation by sex age in American adults. Methods: Data were analyzed for 5406 men women (≥ 20 years old) who participated cycles of National Health Nutrition Examination Survey 2013–2016, a cross‐sectional study. Total (pg/mL) was measured categorized (low, normal, high) based on NHANES protocol. Sleep classified as ≤ 6, 6–9, ≥ 9 h. Weighted multivariable adjusted multinomial logistic regression models conducted to assess these associations. Results: Our analysis revealed no significant associations among both women. Specifically, comparisons durations (≤ 6 h) reference group (6–9 across various categories showed odds ratios low high that remained statistically nonsignificant fully models. These findings suggest that, unlike previous studies linking variations other hormones, do not appear be significantly affected differences either all groups studied. Conclusion: The lack indicates may influence levels general population results underscore importance continued research into how influences hormonal balance. However, it is important note data we used are from study, which cannot establish causal relationship estradiol. Future should investigate additional factors, such genetic predispositions, lifestyle habits, environmental influences, modulate hormone levels.

Language: Английский

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Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats

Behavioral and Brain Functions, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 28, 2025

Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male animals, neglecting potential between sexes. This study aims to investigate sex-specific function under sleep using reward-based operant conditioning tasks. Sprague-Dawley rats were pre-trained on a lever-press task and subsequently divided into control chronic restriction (CSR) groups. The CSR group underwent 14 days of restriction. After modeling, assessed the open field test, retraining lever-pressing task, signal discrimination extinction evaluate motor abilities, memory formation, learning, flexibility. impaired performance both sexes, with requiring more time exhibiting lower accuracy. In showed longer feeding latency accuracy compared females. also specifically increased frequency responses rats. enhanced exploration females higher frequencies than males. Biochemically, induced alterations, including elevated serum MDA MAO levels males serotonin, dopamine, epinephrine Although activation was observed metabolites tryptophan-kynurenine pathway, evident kynurenic acid metabolism prefrontal cortex. female rats, significant observed. Male exhibited discrimination, while learning These accompanied by CSR-induced oxidative stress, neurotransmitter dysregulation, disturbances tryptophan metabolic pathway. findings underscore importance considering understanding effects developing targeted intervention strategies.

Language: Английский

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A prospective study to investigate circadian rhythms as health indicator in women’s aging

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 28, 2025

Abstract The circadian clock plays a crucial role in regulating the timing of numerous physiological processes. Its dysregulation has severe implications for organism’s homeostasis and is among main characteristics aging. As women age transition through menopause, disruptions rhythms may occur, leading to symptoms such as insomnia, mood changes, or altered energy levels. In this prospective non-randomized cohort study, we seek characterize better understand alterations across various stages their reproductive cycle, both with without daily routine (e.g., specific diet, light exposure). Understanding intricate relationship between female health during aging process essential developing targeted interventions mitigate promote overall well-being menopausal women. Findings from study will be used devise tailored rhythm assessments women, facilitating alleviation menopause-related promoting healthy

Language: Английский

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Unraveling sleep quality in menopausal women: objective assessments and self-reported experiences – a mini-review

Climacteric, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 11, 2025

Sleep is a cornerstone of health, playing an integral role in both physiological and psychological functions. However, it vulnerable to variety factors including menopause. According available research, the onset menopause transition may not necessarily worsen sleep architecture could even enhance it, leading conflict between assessment subjective objective complaints. This discrepancy highlights complex relationship quality. Understanding this remains challenging due limited number longitudinal studies small sample sizes. review explores findings from assessments menopausal women examines impact hormone therapy on

Language: Английский

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Multidimensional Sleep and Self-Rated Physical Health and Depressive Symptoms Among Retired Older Adults: A Sex-Stratified Analysis

Behavioral Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: April 17, 2025

Individual sleep characteristics have been shown to independently influence physical and mental health in older adults, but these are often interdependent. However, few studies explored multidimensional relation self-rated outcomes among retired particularly with regard sex differences. This study examined the associations between health, (i.e. depressive symptoms) adults (M years of retirement = 6.59), stratified by sex. Participants (n 154; Mage 68.4, 55.2% female) reported (RAND-12) symptoms (CES-D). Multidimensional was measured using wrist actigraphy assess efficiency, timing, duration, regularity, diaries evaluate daytime alertness satisfaction. Each component dichotomized summed for a composite score (0-6). Hierarchical linear regressions relationships outcomes. Women had poorer compared men. In full sample, associated worse symptoms. Sex-stratified analyses revealed significant only women. is Future research should explore why may be more salient women vs. men their links outcomes, providing insights tailored interventions.

Language: Английский

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Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Neurotrauma Reports, Journal Year: 2025, Volume and Issue: 6(1), P. 322 - 335

Published: Jan. 1, 2025

Traumatic Brain Injuries (TBIs) are known to cause a myriad of symptoms in patients. One common symptom after injury is sleep disruptions. neuropeptide system has been studied repeatedly as potential disruptions TBI- the orexin/hypocretin system. Orexin promotes wakefulness and arousal while disrupting orexin causes increased sleepiness narcolepsy. Studies TBI human animal subjects have shown that affects This review serves an overview how system, including structural functional changes neurons injury. first include studies examine receptors. also examines sex accounted for TBI.

Language: Английский

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Association between sleep duration and patterns and obesity: a cross-sectional study of the 2007–2018 national health and nutrition examination survey

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 21, 2025

We intend to explore whether sleep duration and patterns were associated with obesity among the adult American population. Our study analyzed data from 4540 adults (2007-2008, 2015-2018) in National Health Nutrition Examination Survey (NHANES) database. Self-reported questionnaires used collect on duration, excessive daytime sleepiness, problems. The overall pattern score was calculated categorized into three types: healthy, intermediate, poor patterns. Multivariable logistic regression models calculate associations between obesity. further conducted linearity tests using restricted cubic splines dose-response relationship Additionally, we performed stratified interaction analyses understand if this stable different subgroups. After adjusting for potential confounding factors, (odds ratio [OR] = 0.91, 95% confidence interval [CI]:0.87-0.95, P < 0.001) (OR 1.18, CI: 1.1-1.27, independently There a non-linear obesity, threshold of approximately 9.73 h. effects CI below above 0.89 (0.849-0.936) 2.023 (1.113-3.677), respectively. Unhealthy shorter positively correlated occurrence, there occurrence Interventions aimed at promoting healthy habits appropriate may be important reducing risk

Language: Английский

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Activation of anoctamin-1 calcium-activated chloride channels reduces voluntary alcohol consumption in rats.

Neuropharmacology, Journal Year: 2025, Volume and Issue: 275, P. 110498 - 110498

Published: May 3, 2025

Language: Английский

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Magnitude and Mechanism of Phrenic Long-term Facilitation Shift Between Daily Rest Versus Active Phase

Function, Journal Year: 2023, Volume and Issue: 4(6)

Published: Jan. 1, 2023

Plasticity is a fundamental property of the neural system controlling breathing. One key example respiratory motor plasticity phrenic long-term facilitation (pLTF), persistent increase in nerve activity elicited by acute intermittent hypoxia (AIH). pLTF can arise from distinct cell signaling cascades initiated serotonin versus adenosine receptor activation, respectively, and interact via powerful cross-talk inhibition. Here, we demonstrate that daily rest/active phase duration hypoxic episodes within an AIH protocol have profound impact on magnitude mechanism due to shifts serotonin/adenosine balance. Using historical "standard" (3, 5-min moderate episodes), unaffected exposure midactive midrest phase, yet driving serotonin-dominant (midrest) adenosine-dominant (midactive). This mechanistic "flip" results combined influences hypoxia-evoked release fluctuations basal spinal adenosine. Since evokes less with shorter (15, 1-min) episodes, amplified diminished constraint serotonin-driven plasticity; contrast, elevated background during suppresses pLTF. These findings importance balance regulating amplitude AIH-induced emerging as promising therapeutic modality restore nonrespiratory movements people cord injury or ALS, knowledge how time-of-day episode has biological, experimental, translational implications.

Language: Английский

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Sleep pathology and use of anabolic androgen steroids among male weightlifters in Norway

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 22, 2024

Abstract Use of anabolic androgenic steroids (AAS) causes drastic changes in hormonal milieu and is associated with a range medical psychological consequences. Sleep pathology common side-effect AAS use but few have studied these relations. This study examined the relationship between use, distress sleep quality, how phases heavy abstinence influence sleep. The Pittsburgh-Sleep-Quality-Index (PSQI) Jenkins Scale (JSS) were used to assess was measured Hopkins Symptoms Checklist (HSCL). Participants comprised men who previous or current long-term ( n = 68) non-using weightlifting controls (WLC) 58), where subgroup participants 22) monitored over ~ 6 months during withdrawal. Group differences on PSQI JSS evaluated Kruskal-Wallis H tests, mediating role using structural equation modeling. Linear mixed models withdrawal quality. Among group, 66% reported problems as side effect, 38% had medication. scores showed significantly lower quality group compared WLC p < 0.001) all subscales except “sleep latency”. Furthermore, poorer withdrawal-phases than periods .001). Our findings provide key insight into disturbances among AAS, suggesting link hormone levels that deviate from physiologically normal both directions.

Language: Английский

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