Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(2)
Published: Feb. 1, 2023
Abstract Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological preparations developed using this platform. During pandemic, their administration has been proven to be a life‐saving intervention. Here, we review main advantages of mRNA vaccines, identify further technological challenges met during development platform, and provide an update on clinical progress leading vaccine candidates different viruses that include influenza viruses, human immunodeficiency virus 1, respiratory syncytial virus, Nipah Zika cytomegalovirus, Epstein‐Barr virus. The prospects manufacturing in low‐income countries also discussed. ongoing interest research technology likely overcome some existing for (e.g., related storage conditions immunogenicity components lipid nanoparticles) enhance portfolio diseases which classical formulations already authorized. It may open novel pathways protection infections consequences no safe efficient immunization methods currently available.
Language: Английский
Citations
49Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease – A systematic review
International Immunopharmacology, Journal Year: 2022, Volume and Issue: 107, P. 108624 - 108624
Published: March 4, 2022
Language: Английский
Citations
57Neurofilament light chain concentration in an aging population
Aging Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 34(2), P. 331 - 339
Published: Jan. 11, 2022
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies the normal aging population are lacking. It is, therefore, urgent identify influencing factors of NF-L population.We assessed sera a large cohort 409 community-dwelling adults aged over 65 years. We studied association between various physiological also with self-reported comorbidities or life-style habits.We showed that serum was tightly associated cystatin C (r = 0.501, p < 0.0001) consequently, estimated glomerular filtration rate (eGFR) - 0.492; 0.0001). Additionally, dependent on age body mass index (BMI) not sex. Among comorbidities, subjects who reported disorders, cardiovascular history fracture had higher univariate analysis, whereas it only case for disorders multivariate analysis. increased when Mini-Mental State Examination (MMSE) decreased (≤ 25 points) geriatric depression score (GDS) (> 5 both Finally, we providing reference ranges by categories without altered renal function.NF-L driven increasing number depression. Yet, blood kidney function interpretation patients suffering from failure should taken caution.
Language: Английский
Citations
53Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy
Diabetologia, Journal Year: 2022, Volume and Issue: 66(3), P. 579 - 589
Published: Dec. 6, 2022
Abstract Aims/hypothesis No established blood-based biomarker exists to monitor diabetic sensorimotor polyneuropathy (DSPN) and evaluate treatment response. The neurofilament light chain (NFL), a blood of neuroaxonal damage in several neurodegenerative diseases, represents potential for DSPN. We hypothesised that higher serum NFL levels are associated with prevalent DSPN nerve dysfunction individuals recently diagnosed diabetes. Methods This cross-sectional study included 423 adults type 1 2 diabetes known duration less than year from the prospective observational German Diabetes Study cohort. was measured samples fasting participants multiplex approach using proximity extension assay technology. assessed by neurological examination, conduction studies quantitative sensory testing. Associations (defined according Toronto Consensus criteria) were estimated Poisson regression, while multivariable linear quantile regression models used assess associations function measures. In exploratory analyses, other biomarkers panel also analysed similarly NFL. Results found 16% sample. Serum increased age. After adjustment age, sex, waist circumference, height, HbA 1c , duration, type, cholesterol, eGFR, hypertension, CVD, use lipid-lowering drugs non-steroidal anti-inflammatory drugs, (RR [95% CI] per 1-normalised protein expression increase, 1.92 [1.50, 2.45], p <0.0001), slower motor (all <0.0001) ≤0.03) velocities, lower sural action ( =0.0004) thermal detection threshold warm stimuli =0.023 =0.004 hand foot, respectively). There no evidence between or Conclusions/interpretation Our findings provide new associating peripheral dysfunction. present advocates as Graphical abstract
Language: Английский
Citations
42Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9
Published: Feb. 14, 2022
Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific intermediate filaments, neurofilaments, which fill axonal cytoplasm, establish caliber growth, and provide structural support. Dominant missense mutations recessive nonsense in neurofilament gene (
Language: Английский
Citations
41Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage
Neurology Neuroimmunology & Neuroinflammation, Journal Year: 2022, Volume and Issue: 9(3)
Published: March 3, 2022
Background and Objectives
To investigate whether white matter lesion activity, acute axonal damage, density in MS associate with CSF neurofilament light chain (NfL) levels.Methods
Of 101 brain donors (n = 92 progressive MS, n 9 relapsing-remitting MS), ventricular was collected, NfL levels were measured. White lesions classified as active, mixed, inactive, or remyelinated, microglia/macrophage morphology active mixed ramified, ameboid, foamy. In addition, damage assessed using Bielschowsky amyloid precursor protein (APP) (immune)histochemistry.Results
measurements of recent (<1 year) clinically silent stroke excluded. correlated negatively disease duration (p = 6.9e-3, r 0.31). without atrophy, positively the proportion containing foamy microglia/macrophages 9.85e-10 p 1.75e-3, respectively), but not those ramified microglia. proportions inactive 5.66e-3) remyelinated 0.03). normal appearing pyramid tract, (Bielschowsky, 0.02, −0.31), presence related to higher (APP, 1.17e-6). The amount rim when compared 4.6e-3 center border (center: 4.6e-3, border, n.s., p 0.03 0.04, respectively).Discussion
Our results demonstrated that microglia show high correlate elevated data support use this biomarker monitor inflammatory demyelinating activity MS.Language: Английский
Citations
40Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis
Neurology, Journal Year: 2024, Volume and Issue: 102(9)
Published: April 22, 2024
Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We evaluated relationship between sNfL and radiologic MS activity through monthly assessments during 24-week natalizumab treatment interruption period in RESTORE (NCT01071083).
Language: Английский
Citations
14Neurofilament light chain in blood as a diagnostic and predictive biomarker for multiple sclerosis: A systematic review and meta-analysis
PLoS ONE, Journal Year: 2022, Volume and Issue: 17(9), P. e0274565 - e0274565
Published: Sept. 14, 2022
Background Neurofilament light chain (NfL) in cerebrospinal fluid (CSF) is a biomarker of multiple sclerosis (MS). However, CSF sampling invasive and has limited the clinical application. With development highly sensitive single-molecule assay, accurate quantification very low NfL levels blood become feasible. As evidence being accumulated, we performed meta-analysis to evaluate diagnostic predictive value MS patients. Methods We literature search on PubMed, EMBASE, Web Science Cochrane Library from inception May 31, 2022. The differences between vs . controls, clinically isolated syndrome (CIS), progressive (PMS) relapsing-remitting (RRMS), relapse remission were estimated by standard mean difference (SMD) corresponding 95% confidence interval (CI). Pooled hazard ratio (HR) 95%CI calculated predict time reach Expanded Disability Status Scale (EDSS) score≥4.0 relapse. Results A total 28 studies comprising 6545 patients 2477 controls eligible for diagnosis value, 5 with 4444 synthesized analysis value. Blood significantly higher age-matched (SMD = 0.64, 0.44–0.85, P<0.001), vs. non-matched 0.76, 0.56–0.96, P<0.001) CIS 0.30, 0.18–0.42, PMS RRMS 0.56, 0.27–0.85, relapsed remitted 0.54, 0.16–0.92, P 0.005). Patients high had shorter EDSS (HR 2.36, 1.32–4.21, 0.004) but similar 1.32, 0.90–1.93, 0.155) compared those levels. Conclusion far as know, this first evaluating MS. present study indicates may be useful diagnosing MS, distinguishing subtypes predicting disease worsening future.
Language: Английский
Citations
35Serum neurofilament light chain in hereditary transthyretin amyloidosis: validation in real-life practice
Amyloid, Journal Year: 2024, Volume and Issue: 31(2), P. 95 - 104
Published: Feb. 13, 2024
Background Neurofilament light chain (NfL) has emerged as a sensitive biomarker in hereditary transthyretin amyloid polyneuropathy (ATTRv-PN). We hypothesise that NfL can identify conversion of gene carriers to symptomatic disease, and guide treatment approaches.
Language: Английский
Citations
8Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes
Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)
Published: Feb. 17, 2024
Abstract Establishing biomarkers to predict multiple sclerosis diagnosis and prognosis has been challenging using a single biomarker approach. We hypothesised that combination of would increase the accuracy prediction models differentiate from other neurological disorders enhance prognostication for people with sclerosis. measured 24 fluid in blood cerebrospinal 77 80 disorders, ELISA or Single Molecule Array assays. Primary outcomes were versus any diagnosis, time first relapse, disability milestone (Expanded Disability Status Scale 6), adjusted age sex. Multivariate calculated area under curve value diagnostic prediction, concordance statistics (the percentage each pair events are correctly ordered Cox regression models) prognostic predictions. Predictions combinations considerably better than The [chitinase-3-like-1 + TNF-receptor-1 CD27] serum [osteopontin MCP-1] had an 0.97 sclerosis, compared best discriminative marker (osteopontin: 0.84) (chitinase-3-like-1 0.84). Prediction next relapse was optimal fluid[vitamin D binding protein Factor I C1inhibitor] serum[Factor B Interleukin-4 (concordance 0.80), Expanded 6 [C9 Neurofilament-light] serum[chitinase-3-like-1 CCL27 vitamin 0.98). A higher significantly improved development sustained Serum rivalled those fluid, holding promise non-invasive utility our can only be established by robust validation different varied cohorts.
Language: Английский
Citations
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