Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking DOI Open Access
Lei Gao, Daryl L. Davies, Liana Asatryan

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15688 - 15688

Published: Dec. 10, 2022

Growing evidence supports the pivotal role of bidirectional interplay between gut microbiota and central nervous system during progression alcohol use disorder (AUD). In our previous study, supplementation with sodium butyrate (SB) in C57BL/6J mice prevented increased ethanol consumption a binge-like drinking paradigm (DID) as result treatment non-absorbable antibiotic cocktail (ABX). this we tested hypothesis that SB protection against enhanced ABX-induced is partially due to modulation neuroinflammatory responses. Pro- anti-inflammatory cytokines, well changes microglia astrocytes were analyzed hippocampus tissues from ABX-, SB-, ABX+SB-treated subjected 4-week DID. We found without or ABX mRNA levels key brain cytokines (MCP-1, TNF-α, IL-1β, IL-6 IL-10) while these changes. Additionally, microglia, i.e., increase Iba-1 positive cell number morphology, astrocytes, decrease GFAP-positive number, induced by combination treatments. Our results suggest metabolites can influence behavior neuroinflammation, highlighting potential for microbiome-targeting strategies prevention AUD.

Language: Английский

Dopamine, Immunity, and Disease DOI Creative Commons

Breana Channer,

Stephanie Matt,

Emily Nickoloff-Bybel

et al.

Pharmacological Reviews, Journal Year: 2022, Volume and Issue: 75(1), P. 62 - 158

Published: Dec. 8, 2022

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions peripheral organs, such as blood pressure, renal activity, intestinal motility. Beyond these functions, growing body of evidence indicates that an important immunoregulatory factor. Most types immune cells express receptors other dopaminergic proteins, take up, produce, store, and/or release dopamine, suggesting immunomodulation for function. Targeting pathways could be promising avenue the treatment inflammation disease, but despite increasing research this area, data on specific effects disease remain inconsistent poorly understood. Therefore, review integrates current knowledge role cell function inflammatory signaling across systems. We discuss understanding regulation CNS tissues, highlighting diseases Parkinson’s several neuropsychiatric conditions, neurologic human immunodeficiency virus, bowel rheumatoid arthritis, others. Careful consideration given to influence experimental design results, we note number areas need further research. Overall, our immunology at cellular, tissue, level prompts development therapeutics strategies targeted toward ameliorating through immunity.

Significance Statement

Canonically, recognized involved cognition, reward. However, acts modulator periphery. This comprehensively assesses pathogenesis cellular tissue level. will provide broad access information fields, identify investigation, drive therapeutic strategies.

Language: Английский

Citations

166

Consequences of adolescent drug use DOI Creative Commons
Michael Steinfeld, Mary M. Torregrossa

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 6, 2023

Abstract Substance use in adolescence is a known risk factor for the development of neuropsychiatric and substance disorders adulthood. This part due to fact that critical aspects brain occur during adolescence, which can be altered by drug use. Despite concerted efforts educate youth about potential negative consequences use, initiation remains common amongst adolescents world-wide. Additionally, though there has been substantial research on topic, many questions remain predictors adolescent In following review, we will highlight some most recent literature neurobiological behavioral effects rodents, non-human primates, humans, with specific focus alcohol, cannabis, nicotine, interactions between these substances. Overall, consumption substances produce long-lasting changes across variety structures networks have enduring behavior, emotion, cognition.

Language: Английский

Citations

158

Endogenous opioid systems alterations in pain and opioid use disorder DOI Creative Commons
Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly

et al.

Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Oct. 19, 2022

Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, pain relief. Endogenous are present ubiquitously throughout the peripheral nervous system. They composed four families, namely μ (MOPR), κ (KOPR), δ (DOPR), nociceptin/orphanin FQ (NOPR) receptors systems. These signal through action their peptides β-endorphins, dynorphins, enkephalins, nociceptins, respectfully, to maintain homeostasis under normal physiological states. Due prominent regulation, exogenous opioids—primarily targeting MOPR, been historically used medicine as analgesics, but ability produce euphoric effects also high risks abuse. The use perturb system particularly within system, may increase likelihood developing disorder (OUD). Today, crisis represents major social, economic, public health concern. In this review, we summarize current state literature on expression, pharmacology, regulation pain. Additionally, discuss adaptations upon opioids which contribute development OUD. Finally, describe intricate relationship between pain, systems, proclivity misuse, well potential generating safer more efficient therapies.

Language: Английский

Citations

47

Opioid use disorder: current trends and potential treatments DOI Creative Commons

Yu Kyung Lee,

Mark S. Gold,

Kenneth Blum

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 25, 2024

Opioid use disorder (OUD) is a major public health threat, contributing to morbidity and mortality from addiction, overdose, related medical conditions. Despite our increasing knowledge about the pathophysiology existing treatments of OUD, it has remained relapsing remitting for decades, with rising deaths overdoses, rather than declining. The COVID-19 pandemic accelerated increase in overall substance interrupted access treatment. If increased naloxone access, more buprenorphine prescribers, greater treatment, enhanced reimbursement, less stigma various harm reduction strategies were effective overdose would not be at an all-time high. Different prevention treatment approaches are needed reverse concerning trend OUD. This article will review recent trends limitations on medications OUD briefly novel that have potential durable medications. focus promising interventional treatments, psychedelics, neuroimmune, neutraceutical, electromagnetic therapies. At different phases investigation FDA approval, these just reduce overdoses deaths, but attenuate as well address comorbid disorders.

Language: Английский

Citations

15

Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder DOI
Anna S. Warden, Nihal A. Salem, Eric Brenner

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective DOI Creative Commons
Khushbu Agarwal, Peter Manza,

Marquis Chapman

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: April 26, 2022

Chronic exposure to addictive drugs in substance use disorders and stressors mood render the brain more vulnerable inflammation. Inflammation brain, or neuroinflammation, is characterized by gliosis, microglial activation, sustained release of cytokines, chemokines, pro-inflammatory factors compromising permeability blood-brain barrier. There increased curiosity understanding how misuse and/or repeated stress affect inflammation contribute abnormal neuronal activity, altered neuroplasticity, impaired cognitive control, which eventually promote compulsive drug-use behaviors worsen disorders. This review will emphasize human imaging studies explore link between function peripheral markers

Language: Английский

Citations

27

Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders DOI Creative Commons
Ming‐Lei Guo, Soheil Kazemi Roodsari, Yan Cheng

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(6), P. 922 - 922

Published: May 31, 2023

During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of abused drugs (cocaine, methamphetamine, alcohol, opiate-like drugs, marijuana, etc.) can modulate activation status microglia and neuroinflammation levels which are involved in pathogenesis SUDs. Several neuroimmune signaling pathways, including TLR/NF-кB, reactive oxygen species, mitochondria dysfunction, well autophagy defection, etc., implicated promoting Recently, inflammasome-mediated has identified playing critical roles induced by drugs. Among family inflammasomes, NOD-, LRR-, pyrin-domain-containing protein 3 (NLRP3) serves primary research target due to its abundant expression microglia. NLRP3 capability integrating multiple external internal inputs coordinately determining intensity under various pathological conditions. Here, we summarize effects on others, if any. The this topic is still at an infant stage; however, readily available findings suggest that inflammasome could be a common downstream effector stimulated play abused-drug-mediated biological through enhancing glia–neuron communications. might serve novel for ameliorating development

Language: Английский

Citations

17

Inflammatory Biomarkers in Addictive Disorders DOI Creative Commons
Álvaro Morcuende, Francisco Navarrete, Elena Nieto

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(12), P. 1824 - 1824

Published: Dec. 3, 2021

Substance use disorders are a group of diseases that associated with social, professional, and family impairment represent high socio-economic impact on the health systems countries around world. These present very complex diagnosis treatment regimen due to lack suitable biomarkers supporting correct classification difficulty selecting effective therapies. Over last few years, several studies have pointed out these addictive systemic central nervous system inflammation, which could play relevant role in onset progression diseases. Therefore, identifying different immune components as such be crucial step promote appropriate treatment. Thus, this work aims provide an overview alterations may various disorders.

Language: Английский

Citations

33

Dynamics and correlations in multiplex immune profiling reveal persistent immune inflammation in male drug users after withdrawal DOI Creative Commons

Guo-Fen Re,

Jie Jia, Yu Xu

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 107, P. 108696 - 108696

Published: March 15, 2022

Drug withdrawal elicits immune responses that contribute to the development of symptoms and relapse. The understanding immunologic dynamics after drug is limited, precluding finding promising intervention measures. Here, we performed cytokine multiplex profiling in heroin, methamphetamine (METH) ephedrine users identified correlation between cytokines other parameters. We showed broad strong inflammatory occurred at early stage withdrawal, a downtrend with extension time. Notably, dysregulation remained through may last longer than 12 months heroin METH users. Our findings suggest cytokines, cells, complement immunoglobulin form complex network regulates withdrawal. These data provide reference for future scientific research development.

Language: Английский

Citations

20

Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions DOI Creative Commons
Mark D. Namba, Qiaowei Xie, Jacqueline M. Barker

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 113, P. 453 - 475

Published: Aug. 9, 2023

Language: Английский

Citations

13