eLife, Journal Year: 2023, Volume and Issue: 12
Published: March 23, 2023
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused mutation the proteasome shuttle factor
Language: Английский
Journal of Neurochemistry, Journal Year: 2022, Volume and Issue: 163(3), P. 179 - 219
Published: Aug. 11, 2022
Neurofilament proteins (Nf) have been validated and established as a reliable body fluid biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, light (NfL), two splicing variants of medium (NfM), heavy (NfH),
Language: Английский
Citations
31
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Brain-derived exosomes released into the blood are considered a liquid biopsy to investigate pathophysiological state, reflecting aberrant heterogeneous pathways of pathological progression brain in neurological diseases. provide promising prospects for diagnosis diseases, with exciting possibilities early and sensitive such However, capability traditional exosome isolation assays specifically isolate characterize brain-derived exosomal proteins by high-throughput proteomics clinical specimens from patients diseases cannot be assured. We report magnetic transferrin nanoparticles (MTNs) assay, which combined samples.The principle MTNs assay is ligand-receptor interaction through on receptor exosomes, electrostatic via positively charged negatively exosomes. In addition, simple rapid (< 35 min) does not require any large instrument. confirmed that accurately efficiently isolated serum samples humans neurodegenerative as dementia, Parkinson's disease (PD), multiple sclerosis (MS). Moreover, we 30 three distinct performed unbiased proteomic analysis explore pilot value protein profiles biomarkers.Using comparative statistical analysis, found 21 candidate biomarkers were significantly different among groups diseases.The convenient approach specific affordable extracellular vesicles body fluids minimally-invasive
Language: Английский
Citations
22
Alzheimer s Research & Therapy, Journal Year: 2023, Volume and Issue: 15(1)
Published: Oct. 6, 2023
Abstract Tauopathies are a group of neurodegenerative disorders characterized by the aggregation microtubule-associated protein tau. Aggregates misfolded tau believed to be implicated in neuronal death, which leads range symptoms including cognitive decline, behavioral change, dementia, and motor deficits. Currently, there no effective treatments for tauopathies. There four clinical candidates phase III trials 16 II trials. While currently approved, is increasing evidence suggest that various therapeutic approaches may slow progression tauopathies or improve symptoms. This review outlines landscape drugs (indexed through February 28, 2023) target pathology describes drug development as well those discovery preclinical phases. The also contains information on notable programs inactive have been discontinued from development.
Language: Английский
Citations
22
Biomarkers in Neuropsychiatry, Journal Year: 2023, Volume and Issue: 8, P. 100062 - 100062
Published: March 23, 2023
In this review, we evaluate the role of fluid biomarkers related to neurodegenerative diseases. Such conditions present diagnostic challenges due phenotypic heterogeneity, longitudinal evolution, overlap between entities, and variability in progression. Biomarkers can potentially provide insight into diagnosis, progression, prognostication, treatment efficacy. This review covers recent advances including beta-amyloid, tau protein, neurofilament light chain, alpha-synuclein glial fibrillary briefly touches upon imaging biomarkers. For each biomarker, discuss pathophysiological correlates, clinical uses, accuracy, limitations.
Language: Английский
Citations
20
eLife, Journal Year: 2023, Volume and Issue: 12
Published: March 23, 2023
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused mutation the proteasome shuttle factor
Language: Английский
Citations
18