1-L Transcription in Prion Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9961 - 9961

Published: Sept. 15, 2024

Understanding the pathogenesis and mechanisms of prion diseases can significantly expand our knowledge in field neurodegenerative diseases. Prion biology is increasingly recognized as being relevant to pathophysiology Alzheimer's disease Parkinson's disease, both which affect millions people each year. This bioinformatics study used a theoretical protein-RNA recognition code (1-L transcription) reveal post-transcriptional regulation protein (PrPC). The principle for this method directly elucidated on PrPC, an octa-repeat be 1-L transcribed into GGA triplet repeat RNA aptamer known reduce misfolding normal PrPC abnormal PrPSc. identified genes/proteins are associated with mitochondria, cancer, COVID-19 ER-stress, approximately half or indirectly For example, supports CD44, regions brain astrocytic accumulation also display high levels CD44.

Language: Английский

VARIANTE ATÁXICA DA DOENÇA DE CREUTZFELDT-JAKOB APÓS INFECÇÃO POR COVID-19: RELATO DE CASO

Revista Contemporânea, Journal Year: 2023, Volume and Issue: 3(12), P. 30336 - 30349

Published: Dec. 19, 2023

Introdução: A Doença de Creutzfeldt-Jakob é a doença priônica humana mais comum. Caracteriza-se por ser uma neurodegenerativa rara e fatal. Ainda não existe tratamento efetivo para esta grave doença. do coronavírus 2019, sua vez, síndrome respiratória causada pelo SARS-Cov-2, que além alterações respiratórias, também causa neurológicas devido à capacidade neuroinvasiva através da proteína spike. Relato Caso: Neste relato caso descrito um paciente adulto, previamente hígido, em vigência infecção SARS-Cov-2 iniciou quadro agudo vertigem evoluiu com alteração neurológica, ataxia demência rapidamente progressiva. Após exames laboratoriais imagens, foi confirmado o diagnóstico (DCJ), variante clínica atáxica Brownell-Oppenheimer. Paciente óbito após 4 meses 7 início clínico. Conclusão: O envolvimento sistema nervoso pela Covid 19 bem envolve, dentre outros mecanismos, estado neuroinflamatório. Este destaca relação temporal ocorrida entre SARS-CoV-2 neurodegeneração DCJ, ênfase aspectos clínicos diagnósticos. Essa associação estudos são necessários elucidação fisiopatogênese especificidades clínico-diagnósticas envolvidas.

Creutzfeldt -Jakob Disease Associated with E200K Mutation and SARS-Cov2 Infection, Pure Coincidence or Neurodegenerative Acceleration?

Published: Dec. 27, 2023

it has been just over three years since SARS-CoV-2 viral infection was first known as causing severe acute and highly transmissible respiratory syndrome coronavirus. During one of the worst global pandemics last century, caused by COVID-19 disease, under persistent immune pressure exerted newest vaccines, virus is fastly mutating becoming less severe, but more contagious. On other hand, some studies [1,2,3] indicate that elderly patients or those who have reported a virulent episode this infection, experience long-lasting neurological complications, including encephalopathy, encephalitis, cerebrovascular Parkinson’s disease (PD), Alzheimer’s (AD) prion (PrD). So, there are several recent reports [4,5] developing PrD following but, to best our knowledge, case in Italy on an association PRNP E200K somatic mutation with gCJD. The rising prevalence neurodegenerative complications adds urgency study potential relationship.

Language: Английский