Genetic association between serum 25-hydroxyvitamin D levels and functional outcome after ischemic stroke DOI Creative Commons
Yudan Wu, Tianyu Jin,

Qiongyi Pang

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 30, 2024

Previous observational studies suggest that serum 25-hydroxyvitamin D [25(OH)D] levels may associate with functional outcome after ischemic stroke. However, the causal relationship is not yet defined. Consequently, this study employed two-sample Mendelian Randomization (MR) to elucidate association between 25(OH)D and The genome-wide (GWAS) for included 417,580 patients of European descent. GWAS stroke from Genetics Ischemic Stroke Functional Outcome meta-analysis. Post-stroke outcomes were evaluated using two sets binary categorical variables (0–2 vs. 3–6 0–1 2–6), also as ordered modified Rankin Scale (mRS) at 3 months. Two-sample MR was used assess whether exposure causally affects outcome. Inverse Variance Weighted (IVW) primary method our analysis, which further supported by sensitivity analyses ensure robustness results. analysis IVW indicated no significant casual mRS (0–1) (2–6) months (OR = 0.914, 95% CI: 0.587–1.422, P 0.69), (0–2) (3–6) 0.699, 0.477–1.025, 0.07), 1.202, 0.875–1.650, 0.26). Additionally, adjusting severity, showed 0.93, 0.55–1.56, 0.78), 0.73, 0.47–1.13, 0.16), 1.09, 0.77–1.54, 0.62). results findings are robust. Our offers genetic evidence supporting effects on associations observed in previous be attributed residual confounding factors reverse causality.

Language: Английский

Genetic association between serum 25-hydroxyvitamin D levels and functional outcome after ischemic stroke DOI Creative Commons
Yudan Wu, Tianyu Jin,

Qiongyi Pang

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 30, 2024

Previous observational studies suggest that serum 25-hydroxyvitamin D [25(OH)D] levels may associate with functional outcome after ischemic stroke. However, the causal relationship is not yet defined. Consequently, this study employed two-sample Mendelian Randomization (MR) to elucidate association between 25(OH)D and The genome-wide (GWAS) for included 417,580 patients of European descent. GWAS stroke from Genetics Ischemic Stroke Functional Outcome meta-analysis. Post-stroke outcomes were evaluated using two sets binary categorical variables (0–2 vs. 3–6 0–1 2–6), also as ordered modified Rankin Scale (mRS) at 3 months. Two-sample MR was used assess whether exposure causally affects outcome. Inverse Variance Weighted (IVW) primary method our analysis, which further supported by sensitivity analyses ensure robustness results. analysis IVW indicated no significant casual mRS (0–1) (2–6) months (OR = 0.914, 95% CI: 0.587–1.422, P 0.69), (0–2) (3–6) 0.699, 0.477–1.025, 0.07), 1.202, 0.875–1.650, 0.26). Additionally, adjusting severity, showed 0.93, 0.55–1.56, 0.78), 0.73, 0.47–1.13, 0.16), 1.09, 0.77–1.54, 0.62). results findings are robust. Our offers genetic evidence supporting effects on associations observed in previous be attributed residual confounding factors reverse causality.

Language: Английский

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