The Role of Alpha Linolenic Acid on Neuroinflammation: A Systemic Review DOI Open Access

Debby Chesilya Wijaya,

Ni Made Linawati

Jurnal Penelitian Pendidikan IPA, Journal Year: 2024, Volume and Issue: 10(7), P. 3597 - 3604

Published: July 25, 2024

Neuroinflammation, an inflammatory response within the central nervous system (CNS), plays a critical role in various neurological disorders, including neurodegenerative diseases. Alpha linolenic acid (ALA), essential omega-3 polyunsaturated fatty acid, has shown promising health benefits due to its antioxidant and anti-inflammatory properties. This article aims thoroughly examine potential effects of ALA reducing neuroinflammation, emphasizing roles as agent. The review focuses on studies published between 2018 2023, sourced from reputable academic databases such PubMed, Semantic Scholar, Google ScienceDirect, with nine key papers selected. findings indicate that significantly mitigates neuroinflammation by decreasing reactive oxygen species (ROS) via Nrf-2/HO-1/JNK signaling pathway. Additionally, reduces cytokines inhibiting p-JNK activation, disrupting lipid rafts, blocking pro-inflammatory transcription factor NF-κB, altering cell membrane phospholipid composition. concludes may have therapeutic through actions, offering possible for conditions, Alzheimer's Parkinson's

Language: Английский

Analgesic and Anti-inflammatory Properties of Dendrobium nobile DOI

Surendra Sarsaiya,

Archana Jain, Qihai Gong

et al.

CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 118 - 142

Published: March 24, 2025

Language: Английский

Citations

0
Voluntary sector lifestyle courses lead to improved outcomes in multiple sclerosis: a qualitative review DOI

Charlie Peel,

Siân Southward,

J. J. O CONNOR

et al.

British Journal of Neuroscience Nursing, Journal Year: 2025, Volume and Issue: 21(Sup 1a), P. S14 - S20

Published: March 1, 2025

There is a significant and growing body of research highlighting the importance lifestyle behaviours in managing symptoms slowing progression multiple sclerosis. The Overcoming MS Program an evidence-based approach that aligns with current findings. educational courses provided by charity support people to access understand evidence around choices their sclerosis, make positive changes within clear framework, experience sustained improvements self-reported mental physical wellbeing, quality life. This article reviews into two education programmes set up draw conclusions about how sclerosis can best be educated supported making sustaining reduce relapse disease progression, as well occurrence comorbidities.

Language: Английский

Citations

0
Healthy Lifestyle and Suicidal Ideation Among Teenagers DOI Open Access

Nanda Wuri Handayani,

Bintang Sasmita Wicaksana, Nandy Agustin Syakarofath

et al.

KnE Social Sciences, Journal Year: 2025, Volume and Issue: 10(7), P. 519 - 535

Published: March 27, 2025

To address the significant prevalence of mental health issues among adolescents, various measures must be implemented. Sustaining a healthy body is particularly important as it significantly influences adolescents’ psychological state. A teenager maintaining lifestyle likely to reduce their risk experiencing homicidal ideation. This study aims investigate whether can serve predictor for suicidal ideation adolescents. employs quantitative methodology utilizing non-correlational experimental design, involving total 647 subjects. The data collection method involved using Healthy Lifestyle Questionnaire (HLQ) and Suicide Ideation Scale (SIS), which were analyzed through simple linear regression multiple with aid Jamovi 2.3 software. findings validated proposed hypothesis, suggesting that healthier associated lower value (p < 0.001), an R -0.397. accounts 15.8%

Language: Английский

Citations

0
Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression DOI Creative Commons
Corinne Pettigrew, Anja Soldan, Jiangxia Wang

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effect of happiness and positive emotions on dementia DOI
Abraham Olufemi Asuku, Gbonjubola Oyinlola Ogungbangbe, Tobiloba Samuel Olajide

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Associations of cardiovascular risk factors and lifestyle behaviors with neurodegenerative disease: a Mendelian randomization study DOI Creative Commons
Liangyu Huang,

Ya‐Nan Ou,

Yuxiang Yang

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 24, 2023

Abstract Previous observational studies reported that midlife clustering of cardiovascular risk factors and lifestyle behaviors were associated with neurodegenerative disease; however, these findings might be biased by confounding reverse causality. This study aimed to investigate the causal associations disease, using two-sample Mendelian randomization design. Genetic variants for modifiable disease extracted from large-scale genome-wide association studies. The inverse-variance weighted method was used as main analysis method, MR-Egger regression leave-one-out analyses performed identify potential violations. Genetically predicted diastolic blood pressure (DBP: OR per 1 mmHg, 0.990 [0.979–1.000]), body mass index (BMI: SD, 0.880 [0.825–0.939]), educational level (OR 0.698 [0.602–0.810]) lower late-onset Alzheimer’s (LOAD), while genetically low-density lipoprotein (LDL: 1.302 [1.066–1.590]) increase LOAD risk. exposures (including LDL BMI) applied familial AD showed same effect. also found Amyotrophic lateral sclerosis (ALS) 1.180 [1.080–1.289]). MR LDL, BMI, BP, causally related AD; a significant between ALS risk, well effect sleep duration on PD revealed. Targeting promising strategy prevention.

Language: Английский

Citations

9
Investigating the Antidepressant Mechanisms of Polygonum sibiricum Polysaccharides via Microglial Polarization DOI Open Access
Yingyu Zhang, Danyang Wang, Jiameng Liu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 438 - 438

Published: Feb. 1, 2024

Polygonum sibiricum, with its medicinal and edibility dual properties, has been widely recognized utilized throughout Chinese history. As a kind of effective component, sibiricum polysaccharides (PSP) have reported to be promising novel antidepressant agent. Meanwhile, the precise mechanisms underlying action remain elusive. The polarization state transition microglia is intricately linked neuroinflammation, indicating crucial involvement in pathophysiology depression. Researchers are vigorously pursuing exploration this potential treatment strategy, aiming comprehend mechanisms. Hence, current study was designed investigate PSP via Microglial M1/M2 Polarization, based on lipopolysaccharide (LPS)-induced BV2 cell activation model. results indicate that significantly inhibited NO LDH release reduced ROS levels LPS-induced cells. could reduce protein expression level Iba-1, decreased mRNA TNF-α, IL-1β, IL-6, increased IL-10. also CD16/32 CD206, fluorescence intensity iNOS, those Arg-1. However, pretreatment reversed alterations BDNF/TrkB/CREB Notch/Hes1 pathways These suggested exerted anti-inflammatory effects by inhibiting M1 phenotype promoting toward M2 phenotype, regulation may associated modulating pathways.

Language: Английский

Citations

3
Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk DOI Open Access
Javier Hernando-Redondo, Mireia Malcampo, Karla Alejandra Pérez‐Vega

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3147 - 3147

Published: Sept. 18, 2024

Individuals with dementia and neurodegenerative diseases (NDDs) often suffer from cardiovascular (CVDs). Neuroinflammation driven by conditions involved in CVDs is linked to disruptions the central nervous system triggering immune reactions, perpetuating an “inflammatory-like” environment. The Mediterranean diet (MedDiet), known for its anti-inflammatory antioxidant properties, has been proposed as a key factor attenuate these risks. Blood nuclear cell samples were collected 134 participants of PREDIMED trial, which randomized three diets: one supplemented extra-virgin olive oil (MedDiet-EVOO), another nuts (MedDiet-Nuts), low-fat control diet. These analyzed at baseline 12-month follow-up assess impact dietary interventions on gene expression markers. We first selected target genes analyzing intersections between NDD CVD associations. Significant changes 12 months observed allocated MedDiet-EVOO, particularly CDKN2A, IFNG, NLRP3, PIK3CB, TGFB2. Additionally, TGFB2 changed over time MedDiet-Nuts group. Comparative analyses showed significant differences MedDiet-EVOO control, NAMPT control. Longitudinal models adjusted different covariates also revealed effects NAMPT. In conclusion, our results suggest that year traditional MedDiet, especially modulates associated risk NDDs older adults high CV risk.

Language: Английский

Citations

3
The role of inflammation in neurological disorders: a brief overview of multiple sclerosis, Alzheimer’s, and Parkinson’s disease’ DOI Creative Commons
Yahveth Cantero‐Fortiz, Merçé Boada

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 29, 2024

Neuroinflammation is a central feature in the pathophysiology of several neurodegenerative diseases, including MS, AD, and PD. This review aims to synthesize current research on role inflammation these conditions, emphasizing potential inflammatory biomarkers for diagnosis treatment. We highlight recent findings mechanisms neuroinflammation, utility disease differentiation, implications therapeutic strategies. Advances understanding pathways offer promising avenues developing targeted interventions improve patient outcomes. Future should focus validating larger cohorts integrating them into clinical practice enhance diagnostic accuracy efficacy.

Language: Английский

Citations

3
A Novel Rat Model for Inflammatory Gut–Brain Interactions in Parkinson's Disease DOI Creative Commons

GE Kendall,

Conor F. Underwood, Louise C. Parr‐Brownlie

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(2)

Published: Jan. 1, 2025

ABSTRACT Gut inflammation is a salient prodromal feature of Parkinson's disease (PD) implicated in pathologic processes leading to nigrostriatal dopaminergic degeneration. However, existing rodent models PD are suboptimal for investigating the interaction between gut and neuropathology. This study aimed develop rat model which exacerbated symptoms induced by parkinsonian lesion. was achieved combining 6‐hydroxydopamine (6‐OHDA) dextran sodium sulfate (DSS) colitis. The characterised using behavioural tests, including reaching, step, gait, open‐field cylinder plus stereological quantification substantia nigra (SN) DA neurodegeneration, histological analysis SN microglial activation distal colon morphology. combination 6‐OHDA DSS resulted greater stool softening bleeding, shorter colons damage, when compared with model. Additionally, rats displayed similar yet less activation, that did not receive DSS. Finally, + exhibited impaired forelimb motor function rats, decreased performance reaching step tests. In conclusion, administration dysfunction rats. Behavioural changes were associated lower levels dopamine depletion 6‐OHDA‐only These results support promising animal investigate deleterious gut–brain interactions PD.

Language: Английский

Citations

0