Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 193, P. 106461 - 106461
Published: March 2, 2024
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of β-amyloid (Aβ) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. So far, our understanding extent role adaptive immune responses AD has been quite limited. T cells, as essential members system, exhibit quantitative functional abnormalities brains patients. Dysfunction blood-brain barrier (BBB) considered one factors leading to cell infiltration. Moreover, degree neuronal loss correlated quantity cells. We first describe differentiation subset functions peripheral cells patients provide an overview key findings related BBB dysfunction how infiltrate brain parenchyma through BBB. Furthermore, we emphasize risk associated AD, including Aβ, Tau protein, microglial apolipoprotein E (ApoE), neuroinflammation. discuss their regulation activation proliferation, well connection between neurodegeneration, Understanding innate response crucial for providing comprehensive personalized therapeutic strategies AD.
Language: Английский
Citations
13Protein modification in neurodegenerative diseases
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: Aug. 1, 2024
Abstract Posttranslational modifications play a crucial role in governing cellular functions and protein behavior. Researchers have implicated dysregulated posttranslational misfolding, which results cytotoxicity, particularly neurodegenerative diseases such as Alzheimer disease, Parkinson Huntington disease. These aberrant cause proteins to gather certain parts of the brain that are linked development diseases. This leads neuronal dysfunction start disease symptoms. Cognitive decline neurological impairments commonly manifest patients, underscoring urgency comprehending modifications’ impact on function for targeted therapeutic interventions. review elucidates critical link between specific modifications, focusing Tau, APP, α‐synuclein, Huntingtin protein, Parkin, DJ‐1, Drp1. By delineating prominent within underscores significance understanding interplay among these modifications. Emphasizing 10 key abnormal this study aims provide comprehensive framework investigating holistically. The insights presented herein shed light potential avenues aimed at modulating mitigate aggregation retard progression.
Language: Английский
Citations
4Effect of perioperative intravenous ketamine on postoperative sleep disturbance in patients undergoing non-cardiac surgery: A systematic review and meta-analysis
Indian Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: 69(5), P. 434 - 449
Published: April 16, 2025
Background and Aims: Postoperative sleep disturbance (PSD) is a common condition that may lead to pain, cognitive impairment, depression, delayed recovery. This review evaluates the efficacy of perioperative intravenous ketamine in alleviating PSD offers evidence-based recommendations for clinical practice. Methods: A systematic search was performed PubMed, Embase, Cochrane Library, Wanfang Data, VIP Information Resource System, China National Knowledge Infrastructure Biology Medicine disc (SinoMed) up 6 th November 2024. article included meta-analysis randomised controlled trials (RCTs) along with Grading Recommendations Assessment, Development Evaluation analysis. Results: total 2355 patients from 21 RCTs were analysed. The pooled results indicated improved quality compared placebo on first postoperative day, as evidenced by reduction Pittsburgh Sleep Quality Index scores [mean difference (MD): −2.69; 95% confidence interval (CI): −3.95, −1.42; P < 0.0001, I 2 = 96%]. Ketamine also second day (MD: −2.45; CI: −3.99, −0.91; 0.002, 96%) during three days −2.90; −4.79, −1.00; 0.003, 97%). In addition, reduced Visual Analogue Scale pain −0.38; −0.55, −0.21; 0.00001, 84%). These suggest reduces PSDs without significantly increasing adverse reactions. However, given high heterogeneity limited evidence this review, should be interpreted caution. Conclusion: indicates administering period can enhance quality. optimal dose, timing method administration remain undetermined, emphasising need further research establish standardised guidelines.
Language: Английский
Citations
0Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats
Journal of Neuropathology & Experimental Neurology, Journal Year: 2024, Volume and Issue: 83(7), P. 596 - 605
Published: April 15, 2024
Cognitive dysfunction following anesthesia with agents such as sevoflurane is a significant clinical problem, particularly in elderly patients. This study aimed to explore the protective effects of phytochemical syringaresinol (SYR) against sevoflurane-induced cognitive deficits aged Sprague-Dawley rats and determine underlying mechanisms involved. We assessed impact SYR on impairment, glial activation, neuronal apoptosis through behavioral tests (Morris water maze), immunofluorescence, Western blotting for key proteins involved inflammation, enzyme-linked immunosorbent assays interleukin-1β, tumor necrosis factor-α, interleukin-6. treatment mitigated decline, reduced microglial astrocyte activation (decreased Iba-1 GFAP expression), countered (reduced Bax, cleaved-caspase3, cleaved-PARP expression). also enhanced Sirtuin-1 (SIRT1) expression p-Tau phosphorylation; these were reversed by SIRT1 inhibitor EX527. exerts neuroprotective modulating activity, apoptotic signaling, Tau phosphorylation pathway. These findings could inform strategies safeguard function patients undergoing anesthesia.
Language: Английский
Citations
2Immunotherapy in Alzheimer’s disease: focusing on the efficacy of gantenerumab on amyloid-β clearance and cognitive decline
Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: 76(9), P. 1115 - 1131
Published: May 20, 2024
Gantenerumab, a human monoclonal antibody (mAb), has been thought of as potential agent to treat Alzheimer's disease (AD) by specifically targeting regions the amyloid-β (Aβ) peptide sequence. Aβ protein accumulation in brain leads amyloid plaques, causing neuroinflammation, oxidative stress, neuronal damage, and neurotransmitter dysfunction, thereby cognitive decline AD. Gantenerumab involves disrupting aggregation promoting breakdown larger aggregates into smaller fragments, which facilitates action Aβ-degrading enzymes brain, thus slowing down progression Moreover, acts an opsonin, coating plaques enhancing their recognition immune cells, which, combined with its ability improve activity microglia, makes it intriguing candidate for plaque clearance. Indeed, multifaceted effects including disaggregation, enhanced recognition, improved microglia activity, may position promising therapeutic approach Of note, reports suggest that albeit capacity reduce or eliminate Aβ, not demonstrated effectiveness reducing decline. This review, after providing overview immunotherapy approaches target AD, explores efficacy levels
Language: Английский
Citations
2Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer’s Disease Research
Experimental Neurobiology, Journal Year: 2023, Volume and Issue: 32(6), P. 423 - 440
Published: Dec. 31, 2023
In preclinical research on Alzheimer's disease and related tauopathies, tau phosphorylation analysis is routinely employed in both cellular animal models. However, recognizing the sensitivity of to various extrinsic factors, notably temperature, vital for experimental accuracy. Hypothermia can trigger hyperphosphorylation, while hyperthermia leads its dephosphorylation. Nevertheless, rapidity response unintentional temperature variations remains unknown. cell cultures, most significant change occurs when cells are removed from incubator before harvesting, models, during anesthesia prior euthanasia. this study, we investigate kinetics N2a SH-SY5Y neuronal lines, as well mice exposed anesthesia. We observed changes within few seconds upon transferring cultures their 37°C room conditions. placed directly ice post-incubation exhibited negligible changes. vivo, isoflurane rapidly resulted hyperphosphorylation needed lose pedal withdrawal reflex mice. These findings emphasize critical importance preventing variation researches focused tau. To ensure accurate results, recommend avoiding euthanasia promptly placing after removal incubator. By controlling fluctuations, reliability validity studies be significantly enhanced.
Language: Английский
Citations
6Could there be an experimental way to link consciousness and quantum computations of brain microtubules?
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: June 24, 2024
Could there be an experimental way to link consciousness and quantum computations of brain microtubules?
Language: Английский
Citations
0Tau Biosensor on Aptamer-modified Interdigitated Electrode for Monitoring Neurological Effect Caused by Anesthesia
Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e37449 - e37449
Published: Sept. 1, 2024
Language: Английский
Citations
0Postoperative Cognitive Dysfunction and Virtual Reality for Cognitive Rehabilitation in Cardiac Surgery Patients: A Short Review
OBM Neurobiology, Journal Year: 2024, Volume and Issue: 08(01), P. 1 - 13
Published: March 19, 2024
Postoperative cognitive dysfunction (POCD) has been observed as a complication after cardiac surgery consistently. The ineffectiveness of current treatments for POCD is causing search non-invasive alternatives. present review aims to consolidate the understanding how VR methods effectively facilitate recovery functioning in patients. To obtain information about effects technology on functions, we investigated PubMed, Scopus, and Web Science Core Collection databases. Our research shown that systems provide feedback, adapt individual needs, high-intensity meaningful exercise promote motor learning. Previous studies have demonstrated multisensory multidomain stimulation functions possible through technology. Thus, rehabilitation patients can be significantly enhanced using virtual reality (VR) technologies.
Language: Английский
Citations
0Therapeutic Potential of Intravenous Ketamine in Early-Onset Dementia: A Case Report
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: July 24, 2024
This case report discusses the use of intravenous (IV) ketamine as a potential therapeutic agent for early-onset dementia. A 56-year-old female with diagnosis dementia showed significant cognitive decline despite trying and failing several standard treatments such memantine, donepezil, rivastigmine. Given promising results in other neurological psychiatric disorders, patient underwent series IV infusions over period two months. Following treatment, there was notable improvement function, mood, daily living activities. By end her treatments, stated she had more mental clarity, increased focus, improved memory, energy. highlights novel treatment approach warrants further investigation larger clinical trials.
Language: Английский
Citations
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