Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1333 - 1333

Published: Feb. 4, 2025

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), and multiple (MS), which are a consequence of the progressive loss neuronal function structure, cause significant cognitive impairment. The incidence these in world’s population is constantly increasing result an aging population. Although genetic environmental factors most often mentioned pathogenetic diseases, evidence points to important role proper nutrition prevention support treatment disorders. A healthy, balanced diet can mitigate risks associated with risk above slow progression by reducing oxidative stress inflammation. Vitamins B, D, E, C, K, have been shown functions protect nervous system. This review demonstrates importance vitamins preventing supporting therapy neurodegenerative diseases. Information regarding health-promoting properties must be effectively communicated consumers seeking their health, particularly context Consequently, this also examines authorized health claims under EU food law related vitamins, assessing promoting awareness vitamins’ potential benefits for neuroprotection management

Language: Английский

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Gaps in dementia knowledge: a nationwide study of public awareness and misconceptions in Bulgaria

Psychogeriatrics, Journal Year: 2025, Volume and Issue: 25(2)

Published: Feb. 27, 2025

Abstract Background Dementia is a global health concern which can be mitigated by primary prevention and improved literacy. Effective educational initiatives are informed studies of dementia knowledge. However, most these conducted in high‐income countries, leaving the Balkan region underrepresented. This study aimed to conduct first investigation knowledge among Bulgarian population, exploring recognition symptoms, general knowledge, risk factors awareness. Methods Using an online survey we assessed following components knowledge: (i) symptoms from vignette; (ii) literacy measured with Knowledge Assessment Scale (DKAS); (iii) about factors. Demographic characteristics, previous experience dementia, patterns informing were also considered study. Results One thousand, eight hundred ninety‐six adults (mean age = 44.99; 51.79% female) completed survey. Half respondents correctly recognised vignette. The average DKAS score was 9.51. linked education, marital status, employment, ethnicity, informational sources. 56.7% thought normal part ageing 74.8% did not know healthy lifestyle reduces dementia. number identified (out 17), many mistakenly citing dental fillings, laziness, witchcraft as contributors Conclusions society has poor understanding highlighting need for awareness education. Policy‐makers should prioritise social issue take coordinated actions educate eradicate harmful misconceptions.

Language: Английский

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Cognitive Health Behaviours and Their Association with Neuroanatomical Changes in the Progression of Alzheimer's Disease and Cognitive Impairment

American Journal of Health Behavior, Journal Year: 2025, Volume and Issue: 49(1), P. 14 - 22

Published: Jan. 31, 2025

Background: Patients suffering from Alzheimer's disease usually experience different neuroanatomical changes such as depression, apathy and irritability. Other cognitive behaviours found are linked with impairment well disease. Cardiovascular issues also to be common among the patients, Aim of Study: This study aims assess health behavior their association within progression impairment. For this purpose, hyperintensities in white matter (WHM) were observed. Methodology: In current longitudinal study, grey atrophy WMH changes, is observed cohort. regard, 120 participants included while 310 220 control groups incorporated. Neuroanatomical determined by using Neuropsychiatric Inventory, which classified into apathy, affective hyperactivity subsyndromes. Automatic technique was used for measuring WMH. Results: The results obtained linear mixed-effects models show that has a significant other subsyndromes groups. Significant context vascular risks. Conclusion: identified major contributor NPS moderate

Language: Английский

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Editorial for the Special Issue “Aging, Age-Related Changes in the Brain and the Progression of Alzheimer’s Disease”

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 318 - 318

Published: April 29, 2025

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline, memory impairment, and synaptic dysfunction [...]

Language: Английский

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Exploring the Role of a Dietitian in an Early Intervention Program for People With Dementia and Their Care Partners: A Composite Case Series

Journal of Applied Gerontology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Symptoms of dementia can impact the nutritional status and quality life people with dementia, but there is limited research exploring dietitian’s role in post-diagnostic care. This study aims to explore a dietitian multidisciplinary program for living community. Participants twelve-week multicomponent, intervention care partners were offered three consultations receive dietary assessment, education advice. Key clinical findings from dietetics case notes 40 analyzed using composite series approach. Of these, 39 required ongoing nutrition support intervention. Common issues identified include insufficient energy and/or nutrient intake, unintentional weight loss, poor management comorbidities difficulties coordination Dietitians are an integral part multicomponent dementia. Future work needed optimize dietetic models. Running headline. Dietetics early

Language: Английский

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Pharmacologic and Nutritional Interventions for Early Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(4), P. 1173 - 1186

Published: May 17, 2024

Background: Early intervention is essential for meaningful disease modification in Alzheimer’s (AD). Objective: We aimed to determine the efficacy and safety of pharmacologic nutritional interventions early AD. Methods: PubMed, Embase, Cochrane Library, ClinicalTrials.gov were searched from database inception until 1 September 2023. included randomized controlled trials that evaluated Only demonstrated compared placebo network meta-analysis (NMA). Then we performed frequentist fixed-effects NMA rank interventions. GRADE criteria used evaluate level evidence. Results: Fifty-eight including a total 33,864 participants 48 eligible inclusion. Among analyzed, only 6 (12.5%) treatments— ranging low high certainty— showed significant improvement cognitive decline placebo. High certainty evidence indicated donanemab (standardized mean difference [SMD] –0.239, 95% confidence interval [CI] –0.343 –0.134) lecanemab (SMD –0.194, CI –0.279 –0.108) moderately slowed clinical progression patients with amyloid pathology. Additionally, methylphenidate, donepezil, LipiDiDiet, aducanumab However, there was no serious adverse events as reported between six Conclusions: 12.5% studied reducing impairment Donanemab have potential slow Further required

Language: Английский

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Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8982 - 8982

Published: Aug. 18, 2024

Alzheimer's disease (AD) is characterized by, among other things, dementia and a decline in cognitive performance. In AD, has neurodegenerative features starts with mild impairment (MCI). Research indicates that apoptosis neuronal loss occur which oxidative stress plays an important role. Therefore, reducing antioxidants natural strategy to prevent slow down the progression of AD. Carotenoids are pigments commonly found fruits vegetables. They include lipophilic carotenes, such as lycopene, α- β-carotenes, more polar xanthophylls, for example, lutein, zeaxanthin, canthaxanthin, β-cryptoxanthin. can cross blood-brain barrier (BBB) scavenge free radicals, especially singlet oxygen, helps peroxidation lipids abundant brain. As result, carotenoids have neuroprotective potential. Numerous vivo vitro studies, well randomized controlled trials, mostly confirmed help neurodegeneration alleviate While not been officially approved AD therapy, they indicated diet recommended including consumption products rich carotenoids. This review summarizes latest research findings supporting potential use preventing alleviating symptoms. A literature suggests should be promoted avoid One goals food industry encourage enrichment functional substances, carotenoids, may reduce risk diseases.

Language: Английский

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Advancing nutrition science to meet evolving global health needs

European Journal of Nutrition, Journal Year: 2023, Volume and Issue: 62(S1), P. 1 - 16

Published: Nov. 28, 2023

Populations in crisis!A global overview of health challenges and policy efforts within the scope current nutrition issues, from persistent forms undernutrition, including micronutrient deficiency, to diet-related chronic diseases. Nutrition science has evolved a therapeutic prevention emphasis include focus on diets food systems. Working consensus definitions are needed, as well guidance related healthy emerging issues that require further research building. Between nutrient deficiency disease, focusing exclusively extremes overt disease prevention, equipping bodies with ability cope physiologic, metabolic, psychological stress. Just what is 'optimal nutrition', valid public goal, terminology being provided by community? 'healthspan', resilience, intrinsic capacity may provide evidence support optimal nutrition. Finally, experts views ongoing achieving or acceptance various interventions for promotion, how these can inform government policies.Nutrition topics receive particular proceedings choline, NAD-replenishment neurodegenerative diseases, xanthophyll carotenoids. Choline crucial essential cellular metabolism, requiring consumption foods supplements due inadequate endogenous synthesis. Maternal choline intake vital fetal infant development prevent neural tube defects. Neurodegenerative diseases pose growing challenge, lacking effective therapies. Nutrition, NAD-replenishing nutrients, might aid prevention. Emerging indicates carotenoids enhance vision cognition, potentially impacting age-related

Language: Английский

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Thirty Risk Factors for Alzheimer’s Disease Unified by a Common Neuroimmune–Neuroinflammation Mechanism

Brain Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 41 - 41

Published: Dec. 31, 2023

One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity—a complexity that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g., vasculopathy, proteopathy) were multiple factors, dysfunction neuroimmune–neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis

Language: Английский

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Successful Treatment of Chronic Actinic Dermatitis with Tofacitinib

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 399 - 407

Published: Feb. 1, 2024

Abstract: We present the case of a 58-year-old male patient who presented with pruritic skin plaques and papules on scalp, face, back, back hands for over year. The symptoms worsened upon exposure to sunlight improved cloudy days. Despite previous attempts at treatment glucocorticoid ointment antihistamine drugs, experienced progressive aggravation symptoms. Physical examination revealed hypertrophic infiltrating nodules, significant scratches local exudation. Skin biopsy confirmed diagnosis sun-induced dermatosis. was initiated tofacitinib, an oral Janus Kinase inhibitor, along halometasone ointment, ebastine tablets, strict sun protection. Over course four revisits spanning months, improvement in symptoms, rash almost disappearing pruritus subsiding. well tolerated no adverse effects were observed. Follow-up six months post-treatment showed recurrence This highlights efficacy tofacitinib managing suggests it as potential therapeutic option similar cases. Keywords: dermatosis, chronic actinic dermatitis,

Language: Английский

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