Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Nov. 18, 2024
Background
Obesity
is
associated
with
a
systemic
inflammatory
state
that
contributes
to
neuroinflammation
and
increases
the
risk
of
stroke
at
an
early
age.
Stroke
third
leading
cause
death
worldwide
permanent
disability.
This
work
aimed
assess
whether
obesity-induced
can
be
prognostic
factor
improved
oral
administration
silymarin,
anti-inflammatory
neuroprotective
drug.
Methods
Male
C57/Bl6
mice
were
used
establish
obesity
model
through
high-fat
diet
(HFD)
for
12
weeks.
Cerebral
ischemia
was
performed
photothrombosis
in
left
motor
cortex
end
diet.
Following
induction
ischemia,
silymarin
(100
mg/kg)
administered
orally
14
days.
Levels
pro-inflammatory
(IL1β,
TNFα,
MCP1)
markers
(IL4,
IL10),
neurotrophic
factors
(IGF1,
BDNF),
CX3CL1
assessed
striatum
using
ELISA.
Results
Mice
on
HFD
gained
significantly
more
weight
than
control
subjects
exhibited
altered
glucose
metabolism,
which
after
treatment.
The
survival
rate
lower
(52.2%)
compared
(86%).
Silymarin
treatment
both
ischemic
groups
(non-diet
control:
95.7%,
HFD:
78.3%).
raised
cortical
IL4,
IL10,
IGF1,
BDNF,
levels
group
stroke,
while
did
not
present
relevant
differences.
Conclusion
Our
findings
suggest
improves
possibly
impacting
post-stroke
obese
mice.
increased
BDNF
along
microglial
regulatory
CX3CL1,
may
contribute
observed.
These
results
indicate
could
potential
therapeutic
option
managing
enhancing
outcomes
individuals.
Clinical Nutrition ESPEN,
Journal Year:
2024,
Volume and Issue:
63, P. 476 - 490
Published: July 2, 2024
The
search
for
integrative
and
natural
therapies
that
favor
homeostasis
to
boost
sleep
diet
quality
took
place
young
adult
populations
as
a
non-pharmacological
strategy
long-term
good
of
life.
Thus,
the
present
pilot
study
aims
investigate
effects
90-day
consumption
nutraceutical
composition
on
neuro-immune-endocrine
axis,
providing
better
health
improvement.
Poultry Science,
Journal Year:
2024,
Volume and Issue:
103(10), P. 104029 - 104029
Published: June 26, 2024
Micelle
silymarin
(MS)
is
recognized
for
its
diverse
range
of
beneficial
properties,
which
encompass
anti-inflammatory,
antioxidant,
hepatoprotective,
and
antidiabetic
effects.
The
main
objective
this
study
was
to
examine
the
effects
micelle
on
performance,
egg
quality,
blood
profile,
absorption
rate
in
laying
hens.
In
experiment
1:
288
Hy-Line
brown
hens,
28
wk
old,
were
utilized
experiment.
hens
randomly
allocated
into
3
dietary
treatment
groups,
with
each
group
comprising
eight
replicates
12
housed
individual
pens
access
feed
water.
Over
a
12-wk
feeding
trial,
provided
basal
diet
supplemented
different
levels
MS:
0,
0.03,
0.06%.
2:
For
experiment,
192
Brown
divided
2
replications
treatments
were:
TRT1,
+
powder
4%;
TRT2,
MS
4%.
From
first
findings
revealed
that
incorporating
hens'
significantly
increased
weight
at
6
(P
<
0.05).
Similarly,
throughout
entire
significant
observed
downgraded
count,
production,
weight,
conversion
ratio
(FCR)
Moreover,
Haugh
Units
(HU)
albumen
height
showed
linear
improvement
0.05)
4
supplementation.
Furthermore,
there
increase
yolk
color,
height,
eggshell
thickness
8
supplementation
layers-fed
HU,
strength,
12.
Regarding
profile
parameters,
reductions
aspartate
aminotransferase
(AST),
alanine
(ALT),
lactate
dehydrogenase
(LDH)
0.05),
whereas
tendency
albumin,
triglyceride,
cholesterol
0.10).
second
it
higher
TRT2
compared
TRT1
2-
4-h
intervals
following
administration.
summary,
increasing
enhanced
profile.
Additionally,
form
than
form.
Brain Research Bulletin,
Journal Year:
2024,
Volume and Issue:
216, P. 111039 - 111039
Published: July 31, 2024
Huntington's
disease
(HD)
is
a
scarce
neurodegenerative
disorder
defined
by
chorea
(unusual
involuntary
movements),
behavioral
presentations,
psychiatric
features,
and
cognitive
deterioration.
Although
the
precise
pathogenic
mechanism
behind
HD
has
not
yet
been
identified,
most
widely
acknowledged
pathways
include
excitotoxicity,
mitochondrial
malfunction,
neuroinflammation,
neurochemical
imbalance,
oxidative
stress,
apoptosis
no
efficient
therapy.
Current
medications
have
drawbacks.
Silymarin,
compound
made
up
of
standardized
extracts
obtained
from
seeds
Silybum
marianum
polyphenolic
flavonolignan,
utilized
in
therapeutic
settings
to
treat
variety
experimental
disorders
animals.
Silymarin's
key
pharmacological
activities
anti-cancer,
hepatoprotection,
antioxidant,
cardioprotection,
anti-inflammatory.
It
also
adverse
side
effects
on
people
or
The
current
study
aims
provide
neuro-pharmacological
qualities
HD.
In
this
study,
Thirty-six
male
Sprague-Dawley
rats
(200-220
g,
8
weeks)
at
initial
were
used.
Silymarin
solution
(100
mg/Kg)
was
administered
oral
gavage
for
21
days
ameliorate
neural
damage
injected
with
3-nitropropionicacid
(3-NP)
preliminary
rat
model
results
showed
that
administration
silymarin
reduced
gliosis,
improved
motor
coordination
muscle
activity,
increased
striatal
volume
number
neurons
glial
cells.
Our
suggest
provides
protective
environment
nerve
cells
can
beneficial
against
harmful
Veterinarska stanica,
Journal Year:
2024,
Volume and Issue:
56(2), P. 257 - 264
Published: Aug. 16, 2024
Silymarin
is
a
mixture
of
flavonolignan
fractions
from
the
medicinal
plant
milk
thistle,
which
primarily
used
as
hepatoprotector
in
humans
and
animals,
acts
an
antioxidant,
anti-inflammatory,
antifibrotic,
antiapoptotic
agent.
As
dietary
supplement,
it
increasingly
to
treat
various
liver
diseases,
some
intoxications,
prevent
side
effects
chemotherapy
protect
kidneys
dogs,
birds,
poultry,
rabbits,
cats,
horses
other
animals.
The
use
silymarin
dairy
cows
showed
improved
biochemical
profile
cows,
reduced
occurrence
ketosis
increased
production.
In
pigs,
nutrient
digestibility,
total
average
daily
feed
intake,
weight
gain
improved,
while
sport
horses,
supplementation
accelerated
return
cortisol
levels
pre-exercise
levels.
Lipidosis
or
fatty
disease
common
disorder
among
captive
parrots.
After
long-term
administration
100–150
mg/kg
food
every
8–12
hours,
health
condition
significantly
according
testimonies
parrot
owners
veterinarians.
intensive
poultry
production
systems,
broilers
hepatotonic,
improve
carcass
characteristics,
boost
immune
system
intestinal
health,
growth
promoter,
laying
hens
egg
quality.
addition,
mitigated
negative
mycotoxins
broilers,chickens
Japanese
quails.
Although
numerous
studies
are
known
about
effect
thistle
silymarin,
their
on
animals
not
yet
widespread.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Nov. 18, 2024
Background
Obesity
is
associated
with
a
systemic
inflammatory
state
that
contributes
to
neuroinflammation
and
increases
the
risk
of
stroke
at
an
early
age.
Stroke
third
leading
cause
death
worldwide
permanent
disability.
This
work
aimed
assess
whether
obesity-induced
can
be
prognostic
factor
improved
oral
administration
silymarin,
anti-inflammatory
neuroprotective
drug.
Methods
Male
C57/Bl6
mice
were
used
establish
obesity
model
through
high-fat
diet
(HFD)
for
12
weeks.
Cerebral
ischemia
was
performed
photothrombosis
in
left
motor
cortex
end
diet.
Following
induction
ischemia,
silymarin
(100
mg/kg)
administered
orally
14
days.
Levels
pro-inflammatory
(IL1β,
TNFα,
MCP1)
markers
(IL4,
IL10),
neurotrophic
factors
(IGF1,
BDNF),
CX3CL1
assessed
striatum
using
ELISA.
Results
Mice
on
HFD
gained
significantly
more
weight
than
control
subjects
exhibited
altered
glucose
metabolism,
which
after
treatment.
The
survival
rate
lower
(52.2%)
compared
(86%).
Silymarin
treatment
both
ischemic
groups
(non-diet
control:
95.7%,
HFD:
78.3%).
raised
cortical
IL4,
IL10,
IGF1,
BDNF,
levels
group
stroke,
while
did
not
present
relevant
differences.
Conclusion
Our
findings
suggest
improves
possibly
impacting
post-stroke
obese
mice.
increased
BDNF
along
microglial
regulatory
CX3CL1,
may
contribute
observed.
These
results
indicate
could
potential
therapeutic
option
managing
enhancing
outcomes
individuals.
