A new insight into ayahuasca’s adverse effects: Reanalysis and perspectives on its mediating role in mental health from the Global Ayahuasca Survey (GAS) DOI Creative Commons
Óscar Andión, José Carlos Bouso, Jerome Sarris

et al.

PLOS mental health., Journal Year: 2025, Volume and Issue: 2(4), P. e0000097 - e0000097

Published: April 30, 2025

Ayahuasca is a decoction native to the Amazon, where it plays central role in traditional medicine of many local cultures and has expanded internationally over last decades. also attracted interest scientists for its potential benefits on mental health, but adverse effects are under-researched. We analyzed data from Global Survey, including 10,836 participants who rated predetermined effects. Data were collected March 1st, 2017, December 31st, 2019, accessed analysis November 30th, 2021. Only DP JJS had access identifiable participant data. Machine learning statistical methods used examine relationship between sample characteristics, post-ayahuasca states, health outcomes measured by 12-Item Short Form Survey (SF-12). Among participants, 14.2% (767) prior anxiety disorder 19.7% (1,064) depressive disorder. Despite this, median SF-12 score was 50.16, comparable general population. A history or depression associated with more states after ayahuasca use. However, increased experiences “visual distortions” higher use correlated better health. Women reported did not show worsened The classification psychedelic research should be reconsidered, as certain traditionally labeled negative may contribute long-term psychological benefits. context which these occur, along individual factors, crucial determining whether lead positive outcomes. Understanding dynamics essential improving harm reduction strategies maximizing therapeutic potential. Individuals require special attention, they prone experiencing benefit additional support.

Language: Английский

Psychedelic-Induced Neural Plasticity: A Comprehensive Review and a Discussion of Clinical Implications DOI Creative Commons
Francesco Weiss, Anna Magnesa,

Matteo Gambini

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 117 - 117

Published: Jan. 25, 2025

Background: Psychedelics are increasingly recognized as a promising and innovative treatment strategy for several mental disorders. However, there is still lively controversy in the medical community regards rationale of their employment, specifically indications potential dangers. Methods: A comprehensive literature search on “MEDLINE/PubMed” “Web Science” was performed from inception to 26 June 2024, cross-checking obtained references. We included all studies, i.e., both clinical preclinical, that supplied original data. Results: initially total 1083 entries, 813 MEDLINE/PubMed 270 Web Science. After duplicate elimination, 903 underwent systematic selection. Primary abstract screening yielded 572 candidates eligibility assessment excluded 331 entries formal grounds. Eligibility led exclusion 501 titles. Finally, 70 articles were this review. Discussion: Preclinical evidence genetic expression, histology behavioral studies soundly consistent with psychedelics possessing neuroplasticity-inducing properties. Despite methodological difficulties, seems be inferentially agreement preclinical findings. it unclear whether “neuroplastic boost” induced by classic might dissociable psychodysleptic effects, thereby reducing psychopathological hazards implied these compounds. Moreover, fact so-called “relaxation priors” should unconditionally beneficial appears debatable, further research clarify possible contraindications psychedelic psychoplastogens within precision medicine perspective.

Language: Английский

Citations

7
Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors DOI Creative Commons
Klemens Egger, Helena D. Aicher, Paul Cumming

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Sept. 10, 2024

Abstract The potent hallucinogen N,N- dimethyltryptamine (DMT) has garnered significant interest in recent years due to its profound effects on consciousness and therapeutic psychopotential. DMT is an integral (but not exclusive) psychoactive alkaloid the Amazonian plant-based brew ayahuasca, which admixture of several β -carboline monoamine oxidase A (MAO-A) inhibitors potentiate activity oral DMT, while possibly contributing other respects complex psychopharmacology ayahuasca. Irrespective route administration, alters perception, mood, cognition, presumably through agonism at serotonin (5-HT) 1A/2A/2C receptors brain, with additional actions receptor types overall effects. Due rapid first pass metabolism, nearly inactive orally, but co-administration -carbolines or synthetic MAO-A (MAOIs) greatly increase bioavailability duration action. synergistic MAOIs ayahuasca formulations may promote neuroplasticity, underlies their promising efficacy clinical trials for neuropsychiatric disorders, including depression, addiction, post-traumatic stress disorder. Advances neuroimaging techniques are elucidating neural correlates DMT-induced altered states consciousness, revealing alterations brain activity, functional connectivity, network dynamics. In this comprehensive narrative review, we present a synthesis current knowledge pharmacology neuroscience -carbolines, should inform future research aiming harness full potential.

Language: Английский

Citations

8
Novel mechanisms underlying rapid-acting antidepressants: ketamine-like compounds, neurosteroid GABAkines, and psychedelics DOI Creative Commons

Sara Castanheira,

Catarina Gomes,

Joana Bicker

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104371 - 104371

Published: May 1, 2025

Language: Английский

Citations

0
A new insight into ayahuasca’s adverse effects: Reanalysis and perspectives on its mediating role in mental health from the Global Ayahuasca Survey (GAS) DOI Creative Commons
Óscar Andión, José Carlos Bouso, Jerome Sarris

et al.

PLOS mental health., Journal Year: 2025, Volume and Issue: 2(4), P. e0000097 - e0000097

Published: April 30, 2025

Ayahuasca is a decoction native to the Amazon, where it plays central role in traditional medicine of many local cultures and has expanded internationally over last decades. also attracted interest scientists for its potential benefits on mental health, but adverse effects are under-researched. We analyzed data from Global Survey, including 10,836 participants who rated predetermined effects. Data were collected March 1st, 2017, December 31st, 2019, accessed analysis November 30th, 2021. Only DP JJS had access identifiable participant data. Machine learning statistical methods used examine relationship between sample characteristics, post-ayahuasca states, health outcomes measured by 12-Item Short Form Survey (SF-12). Among participants, 14.2% (767) prior anxiety disorder 19.7% (1,064) depressive disorder. Despite this, median SF-12 score was 50.16, comparable general population. A history or depression associated with more states after ayahuasca use. However, increased experiences “visual distortions” higher use correlated better health. Women reported did not show worsened The classification psychedelic research should be reconsidered, as certain traditionally labeled negative may contribute long-term psychological benefits. context which these occur, along individual factors, crucial determining whether lead positive outcomes. Understanding dynamics essential improving harm reduction strategies maximizing therapeutic potential. Individuals require special attention, they prone experiencing benefit additional support.

Language: Английский

Citations

0