Environmental Light Controls the Daily Organization of Breathing by Activating Brn3b-expressing Intrinsically Photosensitive Retinal Ganglion Cells in Mice DOI
Aaron A. Jones,

Allison R. Spears,

Deanna M. Arble

et al.

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Rhythmic, daily fluctuations in minute ventilation are controlled by the endogenous circadian clock located suprachiasmatic nucleus (SCN). While light serves as a potent synchronizer for SCN, it also influences physiology and behavior activating Brn3b-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). It is currently unclear extent to which external environment shapes ventilatory patterns independent of SCN. To determine relative influence environmental versus timing on organization rhythms ventilation, we used whole-body plethysmography measure breathing mice housed non-entraining T28 cycle (14 h light:14 dark). Using this protocol, found that exhibits ~28-h rhythm with peak at dark onset coincides light:dark animals' locomotor activity. if 28-h was mediated Brn3b-expressing ipRGCs, measured Brn3bDTA under cycle. lack ipRGCs project many non-SCN brain regions. We despite rhythmic cues occurring basis, exhibited 24-h activity, core body temperature consistent The be driven predominantly tidal volume rather than respiratory rate. These data indicate can directly drive way ipRGCs. In addition, these strongly suggest activation principally organizes activity when presented opposition timing.

Language: Английский

Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice. DOI
Aaron A. Jones,

Gabriella M. Marino,

Deanna M. Arble

et al.

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(1), P. E111 - E120

Published: June 5, 2024

The master circadian clock, located in the suprachiasmatic nuclei (SCN), organizes daily rhythm minute ventilation (V̇e). However, extent that V̇e is secondary to SCN-imposed O

Language: Английский

Citations

1
Environmental Light Controls the Daily Organization of Breathing by Activating Brn3b-expressing Intrinsically Photosensitive Retinal Ganglion Cells in Mice DOI
Aaron A. Jones,

Allison R. Spears,

Deanna M. Arble

et al.

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Rhythmic, daily fluctuations in minute ventilation are controlled by the endogenous circadian clock located suprachiasmatic nucleus (SCN). While light serves as a potent synchronizer for SCN, it also influences physiology and behavior activating Brn3b-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). It is currently unclear extent to which external environment shapes ventilatory patterns independent of SCN. To determine relative influence environmental versus timing on organization rhythms ventilation, we used whole-body plethysmography measure breathing mice housed non-entraining T28 cycle (14 h light:14 dark). Using this protocol, found that exhibits ~28-h rhythm with peak at dark onset coincides light:dark animals' locomotor activity. if 28-h was mediated Brn3b-expressing ipRGCs, measured Brn3bDTA under cycle. lack ipRGCs project many non-SCN brain regions. We despite rhythmic cues occurring basis, exhibited 24-h activity, core body temperature consistent The be driven predominantly tidal volume rather than respiratory rate. These data indicate can directly drive way ipRGCs. In addition, these strongly suggest activation principally organizes activity when presented opposition timing.

Language: Английский

Citations

0