Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108691 - 108691
Published: Dec. 16, 2024
Language: Английский
Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: July 22, 2024
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Biomarkers are needed to improve diagnosis, gauge progression, evaluate treatment. Diffusion tensor imaging (DTI) promising biomarker for detecting microstructural alterations in the white matter tracts. This study aimed assess DTI metrics as biomarkers examine their relationship with clinical assessments patients ALS. Eleven ALS 21 healthy controls (HCs) underwent 3T MRI DTI. metrics, including fractional anisotropy (FA), mean diffusivity (MD), radial (RD), axial (AD), were compared between key extra-motor tract groups. Group comparisons correlations also correlated scores disability (ALSFRS-R), muscle strength (dynamometry), unit (MUNIX). Widespread differences found HCs decreased FA increased metrics. However, MD RD more sensitive changes Significant interhemispheric observed. showed symmetry hemispheres assessments. MD, RD, AD increases significantly ALSFRS-R MUNIX weaker dynamometry results. reveals damage along regions patients. can serve quantitative neuroimaging prognosis, monitoring Combined analysis imaging, electrodiagnostic, functional shows potential characterizing pathophysiology progression.
Language: Английский
Citations
1
Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(10)
Published: Oct. 1, 2024
ABSTRACT Background/Objectives This systematic review and meta‐analysis aimed to investigate the role of magnetic susceptibility (χ) in deep gray matter (DGM) structures, including putamen (PUT), globus pallidus (GP), caudate nucleus (CN), thalamus, most common types multiple sclerosis (MS) relapsing‐remitting MS (RRMS), using quantitative mapping (QSM). Methods The literature was systematically reviewed up November 2023, adhering PRISMA guidelines. study conducted a random‐effects model calculate standardized mean difference (SMD) QSM values between patients with RRMS healthy controls (HCs). Publication bias risk were also assessed. Results Nine studies involving 1074 640 HCs included meta‐analysis. results showed significantly higher PUT (SMD = 0.40, 95% confidence interval [CI] 0.22–0.59, p .000), GP 0.60, CI 0.50–0.70, .00), CN 0.15–0.66, .005) compared HCs. However, there no significant differences thalamus −0.33, −0.67–0.01, .026). Age‐ sex‐based subgroup analysis demonstrated that younger (< 40 years) PUT, GP, groups larger male populations (> 25%) had more χ. Interestingly, thalamic found decrease over years age populations. Sex‐based indicated iron levels regardless sex. certain brain regions (PUT, CN) during early stages (disease duration < 9.6 RRMS, but lower later > than Discussion/Conclusion may serve as biomarker for understanding χ value alterations such dysregulation its contribution neurodegeneration especially basal ganglia nuclei CN.
Language: Английский
Citations
1
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: March 6, 2024
Introduction Iron accumulation in the brain has been linked to diabetes, but its role subcortical structures involved motor and cognitive functions remains unclear. Quantitative susceptibility mapping (QSM) allows non-invasive quantification of iron deposition brain. This systematic review meta-analysis examined magnetic measured by QSM nuclei patients with type 2 diabetes mellitus (T2DM) compared controls. Methods PubMed, Scopus, Web Science databases were systematically searched [following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines] studies reporting values deep gray matter (DGM) regions T2DM Pooled standardized mean differences (SMDs) calculated using fixed-effects models, heterogeneity was assessed I . Sensitivity analyses conducted, publication bias evaluated Begg’s Egger’s tests. Results Six including 192 245 controls included. study found a significant increase control group. The moderate increases putamen (SMD = 0.53, 95% CI 0.33 0.72, p 0.00) dentate nucleus 0.56, 0.27 0.85, weak associations between increased levels caudate 0.32, 0.13 0.52, red 0.22, 0.00 0.44, 0.05). No statistical significance alterations globus pallidus 0.19; −0.01 0.38; 0.06) substantia nigra 0.12, −0.10, 0.34, 0.29). analysis showed that findings remained unaffected individual studies, consistent observed multiple areas. Discussion revealed an DGM/subcortical versus controls, particularly nuclei, putamen, nucleus, nucleus. Thus, may serve as potential biomarker patients. However, further research is needed validate these findings.
Language: Английский
Citations
0
Medicine Advances, Journal Year: 2024, Volume and Issue: 2(2), P. 199 - 201
Published: June 1, 2024
Abstract This letter discusses the clinical utility of ultra‐high field magnetic resonance imaging (MRI) at 7 Tesla (7T) for detection and management brain metastases. Brain metastases are most common intracranial tumors their early crucial improving patient outcomes. Conventional MRI may miss subtle lesions, 7T provides unprecedented anatomical details with high spatial resolution improved contrast. It allows visualization fine tumor structures margins, as well infiltration angiogenesis. Techniques such susceptibility‐weighted quantitative susceptibility mapping exploit increased sensitivity to effects, facilitating additional small or hemorrhagic lesions. Advanced methods have also provided novel neuroimaging biomarkers that characterize neuroinflammation neurovascular changes. While acknowledging limitations including cost technical challenges, earlier targeted treatment informed by insights could minimize metastasis damage improve
Language: Английский
Citations
0
IP Indian Journal of Neurosciences, Journal Year: 2024, Volume and Issue: 10(4), P. 182 - 189
Published: Nov. 15, 2024
Neuroferritinopathy is a rare, autosomal dominant neurodegenerative disorder characterized by the accumulation of iron in brain due to mutations ferritin light chain gene (FTL). This article explores incidence, prevalence, pathogenesis, types, and treatment options for neuroferritinopathy, drawing on current scientific literature provide comprehensive overview. clinically presents mid-adulthood, most frequently between third fifth decade life. Onset: Symptoms are often gradual, though patients may develop dystonia, chorea, parkinsonism, cognitive dysfunction.
Language: Английский
Citations
0
Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108691 - 108691
Published: Dec. 16, 2024
Language: Английский
Citations
0