Drug Healthcare and Patient Safety, Journal Year: 2025, Volume and Issue: Volume 17, P. 75 - 85
Published: March 1, 2025
Cholinesterase inhibitors (ChEIs) are recognized as first-line therapies for patients with mild-to-moderate dementia. However, there is limited comparative evidence regarding antipsychotic initiation risk among individual ChEIs to manage behavioral symptoms of This study aims evaluate and compare the dementia prescribed ChEIs. a retrospective cohort using 2009-2018 TriNetX electronic medical records data. Dementia aged over 60 years who were incident users rivastigmine, donepezil, or galantamine 12-month washout period included. Patients history use during baseline 30 days post-initiation excluded. followed up 12 months identify use. A generalized boosted model-based inverse probability treatment weights-adjusted Cox Proportional Hazard (CPH) model was applied across different Among 7,878 eligible initiating ChEIs, 89.40% (n=7,043) donepezil users, by 8.13% (n=641) rivastigmine 2.46% (n=194) users. During follow-up, 807 (10.24%) initiated antipsychotics. The CPH showed that at an increased compared (adjusted hazard ratio=1.45, 95% confidence interval: 1.11-1.88). No significant difference observed in between found more likely initiate antipsychotics while no observed. These findings emphasize importance careful medication monitoring management prevent prescribing cascades reduce related adverse effects patients.
Language: Английский
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0Unraveling temporal patterns of diagnostic markers and comorbidities in Alzheimer's disease: Insights from large‐scale data
Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)
Published: March 1, 2025
Abstract INTRODUCTION Comorbid conditions associated with Alzheimer's disease (AD) are poorly understood regarding timing and potential impact on onset progression. METHODS Medical Information Mart for Intensive Care‐IV electronic health records from 2008 to 2019 were examined. The study identified 2527 AD patients (34.9% male, mean age 80.27 years) among 299,712 patients. We examined the of 12 cardiovascular metabolic diseases relative diagnosis. Data National Coordinating Center validated findings. RESULTS Hypertension was most common comorbidity, diagnosed 1.09 years before AD. Depression only comorbidity after start, 0.16 average. had greater rates hypertension, hypercholesterolemia, depression compared general population. DISCUSSION findings emphasize early detection therapy AD‐related comorbidities, notably diseases. temporal link between these suggests opportunities preventive strategies improved care pathways. Highlights Temporal analysis comorbidities : reveals hypertension hyperlipidemia as leading precursors AD, typically 1 1.3 prior onset, while emerges predominantly Unique data integration Large‐scale datasets MIMIC‐IV ( n = 299,712) NACC 51,836) leveraged identify chronological patterns in key comorbid Sex‐ age‐specific insights prevalence peaks at 80 86 years, females exhibiting higher LOAD males. a post‐diagnostic marker Unlike other depression's (0.16 diagnosis) highlights need targeted mental interventions Implications Findings suggest that managing hyperlipidemia, modifiable midlife may delay or reduce risk development. Comorbidity variability across cohorts hypercholesterolemia showed significantly cohort MIMIC‐IV, reflecting dataset‐specific biases regional healthcare differences. Future research directions Advocates longitudinal, multiethnic, global studies refine diagnostic criteria explore tailored conditions.
Language: Английский
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0Rehabilitation playthings design to promote positive emotions among people living with Alzheimer’s Disease: a conceptual synthesis
Disability and Rehabilitation Assistive Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: April 7, 2025
Purpose: Cognitive decline and social isolation pose significant challenges to the well-being of people with Alzheimer's disease (AD). While recreational activities rehabilitation playthings (RPTs) have demonstrated benefits in fostering positive emotions among this population, there remains a scarcity specifically designed address their unique needs. This study aims develop conceptual framework for RPTs design enhance emotional living AD. Materials Methods: Guided by research question construct classification, identified three key questions. A systematic literature review was conducted using Scopus, Web Science, PubMed these Selected articles were evaluated based on relevance focus improving engagement individuals Results: Through meticulous analysis, fifty-seven selected systematically categorized into sub-themes include: types RPTs, meaningful associated characteristics, principles strategies. The results are further synthesized formulate potential theoretical proposition future investigation. Conclusion: proposed recommends that integrating emotion design, compassionate co-creation, suitable play experiences could preserve personhood elicit
Language: Английский
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0Criminal Behavior in Early Onset Neurodegenerative Diseases
European Journal of Neurology, Journal Year: 2025, Volume and Issue: 32(4)
Published: April 1, 2025
ABSTRACT Introduction Literature on criminal behavior preceding a neurodegenerative disease diagnosis is insufficient. Some studies suggest increased crime rates among patients with frontotemporal dementia (FTD). Methods Patients diseases were gathered from Kuopio and Oulu University Hospitals compared nonselective general population data Statistics Finland ( N = 24,144). Clinical linked to the Finnish national register of police‐reported crimes. Results In total, 2424 participants included. Overall notably higher FTD during year before (9.4% for FTD, 6.3% controls, p 0.019). There was significant drop in 3 years after (4.7% 12.3% < 0.001). Discussion Criminal overrepresented diagnosis. manifesting previously law‐abiding individuals late adulthood should be considered potential early symptom disease.
Language: Английский
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0Suicide Risk in Dementia
Published: Jan. 1, 2025
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