Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3340 - 3340

Published: March 15, 2024

Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies expand boundaries neuropharmacology, studies from field have highlighted gut microbiota’s role modulating these disorders. These alterations may influence brain’s processes through brain–gut axis, multifaceted bidirectional system that establishes connection between enteric central nervous systems. Thus, probiotic prebiotic supplements are meant overall health play an insightful alleviating psychiatric symptoms, such templates major depressive disorder, anxiety, or schizophrenia. Moreover, administration psychotropic drugs has been revealed induce specific changes microbiome’s diversity, suggesting their potential utility combating bacterial infections. This review emphasizes intricate correlations microbiota, mentioning promising approaches regard modulation treatments, well antimicrobial effects medication.

Language: Английский

A Novel 18F- Fallypride PET Imaging Method to Study Dopamine Release in SD Rats Induced by Alkaloids and Nicotine Salts

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Dopamine release plays an important role in regulating neuronal behaviors behind drug addiction and abuse. Plant alkaloids nicotine salts administrations have been reported to exert significant effects on dopamine human animal brains. However, vivo detection of the brain is challenging mostly invasive, which greatly limit its wide application study drug-induced neurological mechanisms. A novel ¹⁸F- Fallypride positron emission tomography (PET) imaging method was demonstrated for secretion SD rats. The four /nicotine (nicotine, benzoate, caffeine arecoline hydrobromide) rats were systematically investigated based PET using 18F-Fallypride as a marker. results showed that effective saturation dosage nicotine, arecine hydrobromide 0.125 mg/kg, 0.150 0.165 mg/kg 0.300 respectively. Besides, there also sex differences intensity under same dose. Additionally, behavior has supported these pharmacological differences. This work provided noninvasive real-time excitability by stimulants better understand abuse ability.

Language: Английский

A Novel 18f- Fallypride Pet Imaging Method to Study Dopamine Release in SD Rats Induced by Alkaloids and Nicotine Salts

Published: Jan. 1, 2024

Language: Английский