Timing and Graded BMP Signalling Determines Fate of Neural Crest and Ectodermal Placode Derivatives from Pluripotent Stem Cells DOI Creative Commons

Keshi Chung,

M. F. Millet,

Ludivine Rouillon

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2262 - 2262

Published: Oct. 4, 2024

Pluripotent stem cells (PSCs) offer many potential research and clinical benefits due to their ability differentiate into nearly every cell type in the body. They are often used as model systems study early stages of ontogenesis better understand key developmental pathways, well for drug screening. However, order fully realise PSCs translational applications, a deeper understanding especially humans, is required. Several signalling molecules play important roles during development required proper differentiation PSCs. The concentration timing signal activation important, with perturbations resulting improper and/or pathology. Bone morphogenetic proteins (BMPs) one such group involved specification various types tissues human body, including those related tooth otic development. In this review, we describe role BMP its regulation, consequences dysregulation disease differentiation, how can be investigate effects modulation development, mainly focusing on Finally, emphasise unique BMP4 refined controlling regulation could lead generation more robust reproducible PSC-derived organoids applications.

Language: Английский

FOXO1‐NCOA4 Axis Contributes to Cisplatin‐Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy DOI Creative Commons

Xue Wang,

Lei Xu, Yu Meng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(40)

Published: Aug. 29, 2024

Abstract Mammalian cochlea spiral ganglion neurons (SGNs) are crucial for sound transmission, they can be damaged by chemotherapy drug cisplatin and lead to irreversible sensorineural hearing loss (SNHL), while such damage also render cochlear implants ineffective. However, the mechanisms underlying cisplatin‐induced SGNs subsequent SNHL still under debate there is no currently effective clinical treatment. Here, this study demonstrates that ferroptosis triggered in following exposure cisplatin. Inhibiting protects against loss, inducing intensifies these effects. Furthermore, prompts nuclear receptor coactivator 4 (NCOA4)‐mediated ferritinophagy SGNs, knocking down NCOA4 mitigates loss. Notably, upstream regulator of identified transcription factor forkhead box O1 (FOXO1) shown directly suppress expression SGNs. The FOXO1 amplifies NCOA4‐mediated ferritinophagy, increases lipid peroxidation, disrupting interaction between knock out mice prevents SGN Collectively, highlights critical role FOXO1‐NCOA4 axis regulating damage, offering promising therapeutic targets mitigation.

Language: Английский

Citations

10
Current multi-scale biomaterials for tissue regeneration following spinal cord injury DOI

Y Zhang,

Zhonghuan Wu,

Junfeng Wu

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: 178, P. 105801 - 105801

Published: July 5, 2024

Language: Английский

Citations

2
The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review DOI Creative Commons
Antonino Maniaci, Marilena Briglia,

Fabio Allia

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 802 - 802

Published: Oct. 8, 2024

Inner ear disorders, including sensorineural hearing loss, Meniere’s disease, and vestibular neuritis, are prevalent conditions that significantly impact the quality of life. Despite their high incidence, underlying pathophysiology these disorders remains elusive, current treatment options often inadequate. Emerging evidence suggests pericytes, a type vascular mural cell specialized to maintain integrity function microvasculature, may play crucial role in development progression inner disorders. The pericytes present microvasculature both cochlea system, where they regulate blood flow, blood–labyrinth barrier, facilitate angiogenesis, provide trophic support neurons. Understanding valuable insights into lead novel diagnostic therapeutic strategies, improving standard living. This comprehensive review aims detailed overview highlighting anatomy physiology analyzing mechanisms contribute Furthermore, we explore potential pericyte-targeted therapies, antioxidant, anti-inflammatory, angiogenic approaches, as well gene therapy strategies.

Language: Английский

Citations

2
Timing and Graded BMP Signalling Determines Fate of Neural Crest and Ectodermal Placode Derivatives from Pluripotent Stem Cells DOI Creative Commons

Keshi Chung,

M. F. Millet,

Ludivine Rouillon

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2262 - 2262

Published: Oct. 4, 2024

Pluripotent stem cells (PSCs) offer many potential research and clinical benefits due to their ability differentiate into nearly every cell type in the body. They are often used as model systems study early stages of ontogenesis better understand key developmental pathways, well for drug screening. However, order fully realise PSCs translational applications, a deeper understanding especially humans, is required. Several signalling molecules play important roles during development required proper differentiation PSCs. The concentration timing signal activation important, with perturbations resulting improper and/or pathology. Bone morphogenetic proteins (BMPs) one such group involved specification various types tissues human body, including those related tooth otic development. In this review, we describe role BMP its regulation, consequences dysregulation disease differentiation, how can be investigate effects modulation development, mainly focusing on Finally, emphasise unique BMP4 refined controlling regulation could lead generation more robust reproducible PSC-derived organoids applications.

Language: Английский

Citations

1