Antioxidants,
Journal Year:
2024,
Volume and Issue:
14(1), P. 23 - 23
Published: Dec. 27, 2024
Particulate
matter
(PM),
particularly
fine
(PM2.5)
and
ultrafine
(PM0.1)
particles,
originates
from
both
natural
anthropogenic
sources,
such
as
biomass
burning
vehicle
emissions.
These
particles
contain
harmful
compounds
that
pose
significant
health
risks.
Upon
inhalation,
ingestion,
or
dermal
contact,
PM
can
penetrate
biological
systems,
inducing
oxidative
stress,
inflammation,
DNA
damage,
which
contribute
to
a
range
of
complications.
This
review
comprehensively
examines
the
protective
potential
products
against
PM-induced
issues
across
various
physiological
including
respiratory,
cardiovascular,
skin,
neurological,
gastrointestinal,
ocular
systems.
It
provides
valuable
insights
into
risks
associated
with
exposure
highlights
therapeutic
promise
herbal
medicines
by
focusing
on
have
demonstrated
properties
in
vitro
vivo
PM2.5-induced
models.
Numerous
phytochemicals
shown
efficacy
mitigating
cellular
damage
through
their
ability
counteract
suppress
pro-inflammatory
responses,
enhance
defense
mechanisms.
combined
actions
collectively
protect
tissues
PM-related
dysfunction.
establishes
foundation
for
future
research
development
effective
interventions
combat
issues.
However,
further
studies,
clinical
trials,
are
essential
evaluate
safety,
optimal
dosages,
long-term
effectiveness
treatments
patients
under
chronic
exposure.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: March 6, 2024
This
paper
delves
into
the
increasingly
recognized
yet
complex
relationship
between
air
pollution
and
Neurological
Diseases.
Although
detrimental
effects
of
on
respiratory
cardiovascular
health
are
well-documented,
its
impact
neurological
cognitive
disorders
is
an
emerging
area
concern.
In
this
mini
review,
we
explore
intricate
mechanisms
by
which
various
pollutants,
such
as
particulate
matter,
nitrogen
oxides,
polycyclic
aromatic
hydrocarbons,
contribute
to
pathologies.
The
focus
lies
role
oxidative
stress
inflammation
in
exacerbating
conditions
like
Alzheimer's
disease
Parkinson's
disease.
By
unraveling
these
connections,
sheds
light
broader
implications
environmental
factors
underscores
urgent
need
for
policy
interventions
mitigate
pollution's
nervous
system.
The Egyptian Journal of Internal Medicine,
Journal Year:
2025,
Volume and Issue:
37(1)
Published: Jan. 24, 2025
Abstract
This
narrative
review
explores
the
relationship
between
air
pollution
and
neurodegenerative
diseases
(NDs).
Historically,
has
been
linked
primarily
to
respiratory
cardiovascular
issues,
but
recent
evidence
suggests
that
it
may
also
impact
neurological
health.
With
global
increase
in
diseases,
understanding
environmental
risk
factors
become
crucial.
The
synthesizes
findings
from
studies,
highlighting
potential
role
of
pollutants—particularly
fine
particulate
matter
(PM2.5),
ozone,
nitrogen
dioxide
(NO2),
heavy
metals—in
onset
progression
NDs.
Key
mechanisms
under
investigation
include
brain
inflammation
microglial
activation,
which
are
believed
contribute
processes.
Animal
human
studies
have
shown
correlations
exposure
increased
cognitive
decline
disorders.
Research
indicates
exacerbate
neuroinflammation
cause
white
abnormalities,
disrupt
neural
communication
function.
Additionally,
emerging
like
residential
greenness
climate
action
could
mitigate
some
these
adverse
effects.
Despite
advancements,
significant
knowledge
gaps
remain,
particularly
regarding
long-term
chronic
specific
molecular
pathways
involved.
shows
need
for
further
research
clarify
develop
targeted
interventions.
Addressing
pollution’s
on
requires
comprehensive
public
health
strategies,
including
stricter
regulations
awareness,
alongside
continued
into
preventive
therapeutic
measures.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1366 - 1366
Published: Oct. 27, 2024
Individuals
affected
by
neurodegenerative
diseases,
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
and
amyotrophic
lateral
sclerosis
(ALS),
are
dramatically
increasing
worldwide.
Thus,
several
efforts
being
made
to
develop
strategies
for
stopping
or
slowing
the
spread
of
these
illnesses.
Although
causative
genetic
variants
linked
onset
diseases
known,
they
can
explain
only
a
small
portion
cases.
The
etiopathology
underlying
process
in
most
patients
is
likely
due
interplay
between
predisposing
environmental
factors.
Epigenetic
mechanisms,
DNA
methylation,
central
candidates
translating
effects
factors
genome
modulation,
play
critical
role
etiology
AD,
PD,
ALS.
Among
main
exposures
that
have
been
an
increased
risk
accumulating
evidence
points
heavy
metals,
pesticides,
air
pollutants.
These
compounds
could
trigger
neurodegeneration
through
different
mainly
neuroinflammation
induction
oxidative
stress.
However,
suggests
also
capable
inducing
epigenetic
alterations
neurons.
In
this
article,
we
review
available
literature
linking
exposure
pollutants
methylation
changes
relevant
neurodegeneration.
Firat University Journal of Experimental and Computational Engineering,
Journal Year:
2025,
Volume and Issue:
4(1), P. 163 - 181
Published: Feb. 18, 2025
Air
pollution
affects
human
health,
the
environment,
and
economy
worldwide.
This
comprehensive
analysis
elucidates
intricate
characteristics
of
air
its
quality
by
amalgamating
latest
study
outcomes
derived
from
papers
published
on
DergiPark
platform
in
Türkiye
throughout
period
spanning
2022
to
2023.
The
our
are
classified
according
their
research
themes.
main
findings
suggest
that
weather,
urbanization,
industry,
wildfires
affect
quality.
Additionally,
COVID-19
pandemic
has
affected
dynamics,
requiring
further
study.
Scientists
have
used
various
methods
forecast,
evaluate,
simulate,
but
challenges
remain
require
new
approaches.
Investigating
causal
pathways
linking
climate
change,
urban
development,
transportation
will
help
us
better
understand
problem.
Empirical
into
effects
health
is
essential
for
making
informed
policy
decisions,
especially
vulnerable
groups.
Evaluating
efficacy
current
regulations
establishing
approaches
can
guide
effective
paper
a
synthesis
scholarly
studies
pertaining
pollution,
providing
overview
extensive
ramifications
associated
with
this
subject
matter.
