A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology DOI Creative Commons
Chen Wang,

Fule Wang,

Yunru Liao

et al.

BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 27, 2024

Abstract Background Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity recent years. Glaucoma micro-stents serve as the foundation for these minimally procedures. Nevertheless, utilization of stents still presents certain short-term and long-term complications. This study aims to elucidate creation novel drainage stent implant featuring diverging channel, produced through microfluidic template processing technology. Additionally, an analysis mechanical properties, biocompatibility, feasibility implantation is conducted. Results The stress concentration value proposed significantly lower, approximately two three times smaller, compared currently available commercial XEN gel stent. indicates stronger resistance bending theory. Theoretical calculations further reveal that initial efficiency gradient 5.76 higher than stents. Notably, vivo experiments conducted at third month demonstrate favorable biocompatibility profile without any observed cytotoxicity. exhibits excellent material stability vitro simulation environment. Conclusions In summary, approach cost-effective efficient preparation process devices, offering additional filtering treatment options glaucoma.

Language: Английский

Fibrosis and Src Signalling in Glaucoma: From Molecular Pathways to Therapeutic Prospects DOI Open Access
Liam Bourke,

Colm O’Brien

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1009 - 1009

Published: Jan. 24, 2025

Glaucoma, a leading cause of irreversible blindness, is characterised by progressive optic nerve damage, with elevated intraocular pressure (IOP) and extracellular matrix (ECM) remodelling in the lamina cribrosa (LC) contributing to its pathophysiology. While current treatments focus on IOP reduction, they fail address underlying fibrotic changes that perpetuate neurodegeneration. The Src proto-oncogene, non-receptor tyrosine kinase, has emerged as key regulator cellular processes, including fibroblast activation, ECM deposition, metabolism, making it promising target for glaucoma therapy. Beyond well-established roles cancer fibrosis, influences pathways critical trabecular meshwork function, aqueous humour outflow, However, complexity signalling networks remains challenge, necessitating further investigation into role pathogenesis. This paper explores therapeutic potential inhibition mitigate glaucoma, offering novel approach halting disease progression.

Language: Английский

Citations

0
Genetics of Angle-Closure Glaucoma DOI

Yunhua Loo,

Zhenxun Wang, Tin Aung

et al.

Advances in Ophthalmology and Optometry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology DOI Creative Commons
Chen Wang,

Fule Wang,

Yunru Liao

et al.

BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 27, 2024

Abstract Background Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity recent years. Glaucoma micro-stents serve as the foundation for these minimally procedures. Nevertheless, utilization of stents still presents certain short-term and long-term complications. This study aims to elucidate creation novel drainage stent implant featuring diverging channel, produced through microfluidic template processing technology. Additionally, an analysis mechanical properties, biocompatibility, feasibility implantation is conducted. Results The stress concentration value proposed significantly lower, approximately two three times smaller, compared currently available commercial XEN gel stent. indicates stronger resistance bending theory. Theoretical calculations further reveal that initial efficiency gradient 5.76 higher than stents. Notably, vivo experiments conducted at third month demonstrate favorable biocompatibility profile without any observed cytotoxicity. exhibits excellent material stability vitro simulation environment. Conclusions In summary, approach cost-effective efficient preparation process devices, offering additional filtering treatment options glaucoma.

Language: Английский

Citations

1