Association between serum sodium and sporadic Parkinson’s disease

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 25, 2025

Background The correlation between serum sodium and sporadic Parkinson’s disease remains unclear currently. This study aimed to assess the association disease. Objective ultimate goal is gain a deeper understanding of implications this relationship Methods We conducted retrospective cross-sectional involving 1,189 participants in PPMI cohort. Age, sex, education years, race, body mass index, calcium, alanine aminotransferase, aspartate white blood cell, lymphocytes, neutrophils, monocytes, red hemoglobin, platelets, total protein, albumin, uric acid, sodium, potassium, urea nitrogen, creatinine, glucose were obtained from all participants. Logistic regression, smooth curve fitting utilized substantiate research objectives. Results overall was 77.5% (921/1189); it 71.9% (143/199), 75.4% (295/391), 76.7% (171/223), 83% (312/376) for quantile1 (Q1, 130–138.9 mmol/L), quantile 2 (Q2, 139–140.9 3 (Q3, 141–141.9 4 (Q4, 142–155 respectively ( p = 0.011). Multivariate odds ratio regression adjusted risk factors demonstrates 1-unit increment raises by 1.11 times, respectively. Smooth splines analysis suggested linear levels (P nonlinearity 0.5). An interaction observed sex their influence on < 0.05). Further exploratory subgroup within age BMI groups showed that there no significant interactions subgroups (all values > Additional sensitivity analyses supported primary findings indicated conclusions are robust. Conclusion highlights inappropriate incident disease, independent confounders. link linear.

Language: Английский

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Identification of inverted U-shaped curve association between serum potassium and prodromal Parkinson’s disease

Clinical Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100323 - 100323

Published: April 1, 2025

Language: Английский

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Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 17, 2025

This study aimed to investigate the relationship between Composite Dietary Antioxidant Index (CDAI) and prevalence of Parkinson's disease (PD), as well explore its with all-cause mortality risk in PD patients. Data from National Health Nutrition Examination Survey (NHANES) database spanning 2007 2018 were used, including 119,609 participants. After excluding individuals aged <18 years, those incomplete follow-up data, missing critical variables such CDAI covariates, final cohort consisted 34,133 Participants categorized into a group (510 individuals) non-PD (33,623 individuals). The values calculated, participants divided three groups based on tertile distribution their scores: Q1 (CDAI < -1.07), Q2 (-1.07 1.74), Q3 >1.74). Weighted logistic regression weighted Cox analyses employed evaluate associations PD, risk. Restricted cubic spline analysis was used further elucidate precise outcome events. significantly lower compared group. adjusting for age, sex, comorbid conditions (hypertension diabetes), blood lipid glucose levels, reduction associated an increased (Q3 vs. Q1, OR = 0.72, p 0.035). In patients decrease higher HR 0.53, 0.018). association particularly pronounced over 60 years old, smokers, hypertension. identified <0.471 factor <0.527 is independent both general population patients, amplified predictive power older adults, hypertensive individuals. Our findings support developing personalized antioxidant-enhancing nutritional interventions high-risk populations suboptimal established

Language: Английский

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Mercury Exposure and Parkinson's Disease Risk: A Cross-Sectional Study Based on National Health and Nutrition Examination Survey 2003-2016

Published: Jan. 1, 2024

Language: Английский

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