Autophagy: a double-edged sword in ischemia–reperfusion injury DOI Creative Commons
Laura H. Tang,

Wangzheqi Zhang,

Liao Yan

et al.

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 7, 2025

Abstract Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insufficient blood supply (ischemia), is exacerbated upon restoration of flow (reperfusion). This phenomenon can lead to irreversible damage and commonly observed in contexts such as cardiac surgery stroke, where temporarily obstructed. During ischemic conditions, anaerobic metabolism tissues organs results compromised enzyme activity. Subsequent reperfusion exacerbates mitochondrial dysfunction, leading increased oxidative stress accumulation reactive oxygen species (ROS). cascade ultimately triggers cell death through mechanisms autophagy mitophagy. Autophagy constitutes a crucial catabolic mechanism within eukaryotic cells, facilitating degradation recycling damaged, aged, or superfluous organelles proteins via lysosomal pathway. essential for maintaining cellular homeostasis adapting diverse conditions. As self-degradation clearance mechanism, exhibits dualistic function: it confer protection during initial phases injury, yet potentially exacerbate later stages. paper aims elucidate fundamental I/R highlighting its dual role regulation effects on both organ-specific systemic responses. By comprehending their implications organ function, this study seeks explore potential therapeutic interventions modulation clinical settings.

Language: Английский

Critical role of microRNAs in cellular quality control during brain aging and neurological disorders: Interplay between autophagy and proteostasis DOI Creative Commons

Rajesh Tamatta,

Abhishek Kumar Singh

Life Sciences, Journal Year: 2025, Volume and Issue: 369, P. 123563 - 123563

Published: March 13, 2025

A decline in cellular quality control mechanisms is one of the processes brain aging. Autophagy and proteostasis are two regulatory that maintain component turnover to preserve homeostasis, optimal function, neuronal health by eliminating damaged aggregated proteins preventing neurodegenerative disorders (NDDs). Impaired autophagy significant hallmarks aging many age-related NDDs. MicroRNAs noncoding RNA molecules have recently been shown be essential for regulating several biological processes, such as autophagy, proteostasis, differentiation, development targeting mRNA's 3'untranslated region (3'UTR). During aging, miRNAs dysregulate resulting abnormal activity protein aggregation, a characteristic This review highlights complex interactions orchestration autophagy. dysregulation impairs autophagic flux accelerates disorders, neuroinflammation, neurodegeneration. Understanding among miRNAs, novel therapeutics

Language: Английский

Citations

0
MicroRNAs and lysosomal membrane proteins: Critical interactions in tumor progression and therapy DOI
Jiahao Xu, Shiqiang Liu, Yujie Jin

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189303 - 189303

Published: March 1, 2025

Language: Английский

Citations

0
Autophagy: a double-edged sword in ischemia–reperfusion injury DOI Creative Commons
Laura H. Tang,

Wangzheqi Zhang,

Liao Yan

et al.

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 7, 2025

Abstract Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insufficient blood supply (ischemia), is exacerbated upon restoration of flow (reperfusion). This phenomenon can lead to irreversible damage and commonly observed in contexts such as cardiac surgery stroke, where temporarily obstructed. During ischemic conditions, anaerobic metabolism tissues organs results compromised enzyme activity. Subsequent reperfusion exacerbates mitochondrial dysfunction, leading increased oxidative stress accumulation reactive oxygen species (ROS). cascade ultimately triggers cell death through mechanisms autophagy mitophagy. Autophagy constitutes a crucial catabolic mechanism within eukaryotic cells, facilitating degradation recycling damaged, aged, or superfluous organelles proteins via lysosomal pathway. essential for maintaining cellular homeostasis adapting diverse conditions. As self-degradation clearance mechanism, exhibits dualistic function: it confer protection during initial phases injury, yet potentially exacerbate later stages. paper aims elucidate fundamental I/R highlighting its dual role regulation effects on both organ-specific systemic responses. By comprehending their implications organ function, this study seeks explore potential therapeutic interventions modulation clinical settings.

Language: Английский

Citations

0