Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies DOI Open Access
Tarequl Islam, Md Shahjalal Sagor,

Noshin Tabassum Tamanna

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(3), P. 112 - 112

Published: March 14, 2025

The appendix, an integral part of the large intestine, may serve two purposes. First all, it is a concentration lymphoid tissue that resembles Peyer’s patches. It also main location in body for creation immunoglobulin A (IgA), which essential controlling intestinal flora’s density and quality. Second, appendix constitutes special place commensal bacteria because its form. Inflammation brought on by variety infectious agents, including bacteria, viruses, or parasites, known as appendicitis. According to number studies, consequences appendectomies be more subtle, relate emergence heart disease, inflammatory bowel disease (IBD), Parkinson’s (PD), among other unexpected illnesses. poorer prognosis recurrent Clostridium difficile infection predicted absence appendix. Appendectomies result gut dysbiosis, consequently causes different outcomes. In this review, we compared compositional differences between microbiome, immunological role microbiome (AM), discussed how appendectomy linked consequences.

Language: Английский

Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers DOI Open Access

James Chmiel,

Marta Stępień-Słodkowska

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 545 - 545

Published: Jan. 16, 2025

Introduction: Amyotrophic lateral sclerosis (ALS) is a complex, progressive neurodegenerative disorder characterized by the degeneration of motor neurons in brain, brainstem, and spinal cord. Several neuroimaging techniques can help reveal pathophysiology ALS. One these electroencephalogram (EEG), noninvasive relatively inexpensive tool for examining electrical activity brain with excellent temporal precision. Methods: This mechanistic review examines pattern resting-state EEG activity. With focus on publications published between January 1995 October 2024, we carried out comprehensive search 2024 across number databases, including PubMed/Medline, Research Gate, Google Scholar, Cochrane. Results: The literature yielded 17 studies included this review. varied significantly their methodology patient characteristics. Despite this, common biomarker typical ALS was found-reduced alpha power. Regarding other oscillations, findings are less consistent sometimes contradictory. As review, three possible explanations provided. main most important one increased cortical excitability. In addition, due to limitations studies, recommendations future research topic outlined enable further better understanding patterns Conclusions: Most showed power deficits patients, reflecting pathological hyperexcitability cerebral cortex. Future should address methodological identified small sample sizes, inconsistent frequency-band definitions, insufficient functional outcome measures, solidify extend current findings.

Language: Английский

Citations

0
Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies DOI Open Access
Tarequl Islam, Md Shahjalal Sagor,

Noshin Tabassum Tamanna

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(3), P. 112 - 112

Published: March 14, 2025

The appendix, an integral part of the large intestine, may serve two purposes. First all, it is a concentration lymphoid tissue that resembles Peyer’s patches. It also main location in body for creation immunoglobulin A (IgA), which essential controlling intestinal flora’s density and quality. Second, appendix constitutes special place commensal bacteria because its form. Inflammation brought on by variety infectious agents, including bacteria, viruses, or parasites, known as appendicitis. According to number studies, consequences appendectomies be more subtle, relate emergence heart disease, inflammatory bowel disease (IBD), Parkinson’s (PD), among other unexpected illnesses. poorer prognosis recurrent Clostridium difficile infection predicted absence appendix. Appendectomies result gut dysbiosis, consequently causes different outcomes. In this review, we compared compositional differences between microbiome, immunological role microbiome (AM), discussed how appendectomy linked consequences.

Language: Английский

Citations

0