Transcutaneous Non-Invasive Vagus Nerve Stimulation: Changing the Paradigm for Stroke and Atrial Fibrillation Therapies? DOI Creative Commons
Carola Y. Förster

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1511 - 1511

Published: Nov. 26, 2024

A new therapeutic approach, known as neuromodulation therapy—which encompasses a variety of interventional techniques meant to alter the nervous system in order achieve effects—has emerged recent years result advancements neuroscience. Currently used methods for include direct and indirect approaches, well invasive non-invasive interventions. For instance, two primary stimulating vagus nerve (VN) are VN stimulation (iVNS) transcutaneous (tVNS). Since latter is non-invasive, basic, clinical, translational studies have focused on auricular (taVNS), tVNS therapy, because its advantages over iVNS, including ease use, greater accessibility, lower side effect profile. taVNS currently novel neuromodulatory application treat cardiovascular, mental, autoimmune diseases. Future applications this technology conditions like atrial fibrillation (AF) or ischemic stroke highly likely due advancement.

Language: Английский

Personalized auricular vagus nerve stimulation: beat-to-beat deceleration dominates in systole-gated stimulation during inspiration - a pilot study DOI Creative Commons
Johanna Tischer, József Constantin Széles, Eugenijus Kaniušas

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Neuromodulation comes into focus as a non-pharmacological therapy with the vagus nerve modulation target. The auricular stimulation (aVNS) has emerged to treat chronic diseases while re-establishing sympathovagal balance and activating parasympathetic anti-inflammatory pathways. aVNS leads still over under-stimulation is limited in therapeutic efficiency. A potential avenue personalization of based on time-varying cardiorespiratory rhythms human body. In pilot study, we propose personalized cardiac-gated evaluate its effects instantaneous beat-to-beat intervals (RR intervals). Modulation RR expected reveal efficiency since efferent cardiac branch stimulated afferent governs RR. Five healthy subjects were subjected aVNS. Each subject underwent two 25-min sessions. first session started non-gated open-loop aVNS, followed by systole-gated closed-loop then non-gated, diastole-gated, each for 5min. second session, systole diastole gated interchanged. Changes are analysed comparing prolongation respect proceeding interval where took place. These changes considered function onset, angle starting R peak. influence respiration phases cardiovagal modulation. results show that tends prolong shorten when after before peak, respectively. later time onset within diastole-gated longer be subsequent interval. tendency raises increasing gradually levels off delay from one slope this rise larger than When considering individual phases, inspiratory seems largest values thus modulatory capacity time-gated This study indicates modulate heartbeat activity which attenuated diseases. highest during inspiration.

Language: Английский

Citations

0
Effects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor planning: a multimodal signal study DOI
Long Chen, Y. Hu, Zhongpeng Wang

et al.

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
The Acute Effects of Varying Frequency and Pulse Width of Transcutaneous Auricular Vagus Nerve Stimulation on Heart Rate Variability in Healthy Adults: A Randomized Crossover Controlled Trial DOI Creative Commons

Peter Atanackov,

Jakob Peterlin,

Maja Derlink

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 700 - 700

Published: March 12, 2025

Background/Objective: Heart rate variability (HRV) is a key biomarker of autonomic function, linked to morbidity and mortality across various diseases. Transcutaneous auricular vagus nerve stimulation (taVNS) shows therapeutic promise, but its effects on HRV the influence specific parameters remain unclear. This study investigated whether acute taVNS depend combinations frequency pulse width. Methods: Seventy-eight healthy adults participated in seven randomized sessions, each testing one six active protocols or an inactive sham condition applied cymba conchae left ear. The varied by (10 Hz 25 Hz) width (100 µs, 250 500 µs). sessions included 15 min baseline, condition, 10 recovery. was calculated using standard deviation NN intervals (SDNN) root mean square successive differences (RMSSD) from continuous ECG recordings. Results: Hz/250 Hz/500 Hz/100 µs significantly increased SDNN time series compared condition. Exploratory analysis revealed increases during second 5 with protocol first recovery protocols. No significant changes RMSSD were found for any protocol. Conclusions: TaVNS safe adults, can acutely enhance overall HRV, as reflected SDNN, do not affect vagally mediated RMSSD. Future studies should optimize maximize physiological clinical outcomes.

Language: Английский

Citations

0
Transcutaneous Non-Invasive Vagus Nerve Stimulation: Changing the Paradigm for Stroke and Atrial Fibrillation Therapies? DOI Creative Commons
Carola Y. Förster

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1511 - 1511

Published: Nov. 26, 2024

A new therapeutic approach, known as neuromodulation therapy—which encompasses a variety of interventional techniques meant to alter the nervous system in order achieve effects—has emerged recent years result advancements neuroscience. Currently used methods for include direct and indirect approaches, well invasive non-invasive interventions. For instance, two primary stimulating vagus nerve (VN) are VN stimulation (iVNS) transcutaneous (tVNS). Since latter is non-invasive, basic, clinical, translational studies have focused on auricular (taVNS), tVNS therapy, because its advantages over iVNS, including ease use, greater accessibility, lower side effect profile. taVNS currently novel neuromodulatory application treat cardiovascular, mental, autoimmune diseases. Future applications this technology conditions like atrial fibrillation (AF) or ischemic stroke highly likely due advancement.

Language: Английский

Citations

0