European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)
Published: March 1, 2025
ABSTRACT The release of synaptic vesicles (SVs) at the junction is a complex process involving various specialized proteins that work in unison. Among these, Bassoon has emerged as significant protein, particularly noted for its association with neurological and aging‐related diseases. Due to structural functional roles, become focus recent research, especially understanding implications neurodegenerative psychiatric disorders. In this narrative review, we explore Bassoon's structure, function, role across spectrum Neurotransmission tightly regulated relies on structures within presynaptic terminal, such active zone (AZ), precisely control SV response incoming signals. AZ comprises network large, multidomain proteins, playing crucial arrangement. facilitates tethering reloading SVs, ensuring responsiveness high‐frequency signals, while also maintaining proteostasis presynapse. This involves orchestrating localization essential neuronal development plasticity. large size unique features enable it interact regulate function multiple making integral functioning. Variants gene have been linked variety conditions, including Progressive Supranuclear Palsy, system atrophy (MSA), epilepsy, schizophrenia, bipolar disorder, Parkinson's disease. review delves into pivotal preserving integrity how disruptions functions may contribute these
Language: Английский