Intracerebellar upregulation of Rheb(S16H) ameliorates motor dysfunction in mice with SCA2

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2507 - 2507

Published: Nov. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Language: Английский

Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1)

Stem Cell Research, Journal Year: 2024, Volume and Issue: unknown, P. 103637 - 103637

Published: Dec. 1, 2024

Language: Английский