Epidemiology of Age-related Hearing Loss from 1990 to 2021: Global Burden of Disease and Forecasted Trends DOI Creative Commons
Jing Ke, Yiting Liu,

Ya Shi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Background: Age-related hearing loss (ARHL) is a prevalent progressive that can lead to emotional impairment and cognitive decline in older adults. The aim of this study was investigate the epidemiologic characteristics ARHL from 1990 2021. Methods: We collected data elderly using National Health Nutrition Examination Survey (NHANES) database 2005 2018. Prevalence disability-adjusted life years (DALYs) for were obtained Global Burden Disease (GBD) Trends burden assessed Joinpoint regression analysis. Slope Inequality Index (SII) Concentration (CI) calculated quantify absolute relative cross-country inequalities burden. Bayesian age-period cohort (BAPC) modeling used predict trends prevalence DALY over next 30 years. Results: Mild moderate predominated among adults U.S. between In 2021, there will be more than 700 million cases globally, increasing by 137.43% 300 1990. age-standardized rate (ASR) has also increased, with an estimated annual percentage change 16%. According analysis, upward trend (ASPR) males intensified after 2010. contrast, ASPR females slowed 2000 As Socio-Demographic (SDI) rises, ASR DALYs show downward trend. Notably, as latest data, 204 countries 21 regions globally still have significant health inequalities, although slope index inequality declined time. Projections global gradual increase ASPR. For affecting main factors include environmental risks, occupational noise. Conclusions: varies gender, age group, geographic region. been on rise time disease high, particularly low- middle-income areas.

Language: Английский

Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes DOI Creative Commons
Kun Zhang, Bo Hou, Tao Yan

et al.

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 200, P. 112676 - 112676

Published: Jan. 10, 2025

Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. However, few effective treatment options are available. Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets. Therefore, we performed systematic genome-wide MR of drug-eligible individuals explore potential targets for ARHL. We obtained data on the expression quantitative trait locis (eQTLs) druggable genes, which were then subjected two-sample analyses co-localisation from ARHL association study genes highly associated Additionally, conducted phenome-wide research, enrichment analysis, protein network construction, drug prediction, molecular docking help develop more targeted treatments. Overall, analysis eQTL showed that 14 significantly GO revealed their primary involvement in biological processes such as endoplasmic reticulum unfolded response, ER-nucleus signaling pathway, fibroblast apoptotic process. important cellular components include Bcl-2 family proteins lumen. After filtering using methods docking, six potentially (BAK1, AMFR, LAMP3, STK17B, ACP5, CD9) (beclomethasone, propyl pyrazole triol, momelotinib, monoisoamyl-2,3-dimercaptosuccinate, pterostilbene, naftidrofuryl) may affect outcomes finally identified. Our findings identified These offer promising leads treatments determine priority development, reducing costs.

Language: Английский

Citations

0
NHANES-based machine learning for cognitive impairment classification and blood and hearing threshold characterization in age-related hearing loss DOI
Zesen Zheng,

Shuimei Li,

Ruilin Li

et al.

Geriatric Nursing, Journal Year: 2025, Volume and Issue: 63, P. 8 - 14

Published: March 13, 2025

Language: Английский

Citations

0
Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects DOI Creative Commons
Olin Torres‐Isidro, Marcela González-Montoya, Manuel Alejandro Vargas-Vargas

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 246 - 246

Published: Feb. 12, 2025

Aging is a process characterized by tissue degeneration, increased susceptibility to chronic degenerative diseases, infections, and the appearance of neoplasms, which leads disability reduction in length quality life. This phenomenon result convergence multiple processes, including mitochondrial dysfunction, fibrosis, inflammation, dysregulation cell death immunosenescence. These processes have as their point an increase production ROS. Avocado oil (Persea americana Mill.) contains diverse array bioactive compounds, oleic acid, phytosterols, chlorophylls, xanthones, xanthines, carotenoids. compounds capacity modulate excessive ROS, thereby reducing progression age-related diseases extending lifespan experimental models aging. In addition, several studies demonstrated efficacy avocado mitigating hypertension; insulin resistance; diabetes; non-alcoholic liver disease; such hearing loss, cognitive decline, neurodegeneration, impaired wound healing. light these findings, it hypothesized that promising agent capable promoting healthspan later stages life owing its direct antioxidant actions activation pathways enhance endogenous levels.

Language: Английский

Citations

0
Epidemiology of Age-related Hearing Loss from 1990 to 2021: Global Burden of Disease and Forecasted Trends DOI Creative Commons
Jing Ke, Yiting Liu,

Ya Shi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Background: Age-related hearing loss (ARHL) is a prevalent progressive that can lead to emotional impairment and cognitive decline in older adults. The aim of this study was investigate the epidemiologic characteristics ARHL from 1990 2021. Methods: We collected data elderly using National Health Nutrition Examination Survey (NHANES) database 2005 2018. Prevalence disability-adjusted life years (DALYs) for were obtained Global Burden Disease (GBD) Trends burden assessed Joinpoint regression analysis. Slope Inequality Index (SII) Concentration (CI) calculated quantify absolute relative cross-country inequalities burden. Bayesian age-period cohort (BAPC) modeling used predict trends prevalence DALY over next 30 years. Results: Mild moderate predominated among adults U.S. between In 2021, there will be more than 700 million cases globally, increasing by 137.43% 300 1990. age-standardized rate (ASR) has also increased, with an estimated annual percentage change 16%. According analysis, upward trend (ASPR) males intensified after 2010. contrast, ASPR females slowed 2000 As Socio-Demographic (SDI) rises, ASR DALYs show downward trend. Notably, as latest data, 204 countries 21 regions globally still have significant health inequalities, although slope index inequality declined time. Projections global gradual increase ASPR. For affecting main factors include environmental risks, occupational noise. Conclusions: varies gender, age group, geographic region. been on rise time disease high, particularly low- middle-income areas.

Language: Английский

Citations

0