Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation DOI
Thi Hong Van Nguyen, François Ferrón, Kazuma Murakami

et al.

ACS Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Human coronaviruses (HCoVs) include seven species: HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERS-CoV, SARS-CoV-1, and SARS-CoV-2. The last three, classified as Betacoronaviruses, are highly transmissible have caused severe pandemics. HCoV infections primarily affect the respiratory system, leading to symptoms such dry cough, fever, breath shortness, which can progress acute failure death. Beyond effects, increasing evidence links HCoVs neurological dysfunction. However, distinguishing direct neural complications from preexisting disorders, particularly in elderly, remains challenging. This study examines association between neurodegenerative diseases like Alzheimer disease, Parkinson Lewy body dementia, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease. It also presents long-term effects of their differential impact across age groups sexes. A key aspect this is investigation sequence structural similarities amyloidogenic spike proteins, provide insights into potential neuropathomechanisms.

Language: Английский

Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation DOI
Thi Hong Van Nguyen, François Ferrón, Kazuma Murakami

et al.

ACS Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Human coronaviruses (HCoVs) include seven species: HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERS-CoV, SARS-CoV-1, and SARS-CoV-2. The last three, classified as Betacoronaviruses, are highly transmissible have caused severe pandemics. HCoV infections primarily affect the respiratory system, leading to symptoms such dry cough, fever, breath shortness, which can progress acute failure death. Beyond effects, increasing evidence links HCoVs neurological dysfunction. However, distinguishing direct neural complications from preexisting disorders, particularly in elderly, remains challenging. This study examines association between neurodegenerative diseases like Alzheimer disease, Parkinson Lewy body dementia, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease. It also presents long-term effects of their differential impact across age groups sexes. A key aspect this is investigation sequence structural similarities amyloidogenic spike proteins, provide insights into potential neuropathomechanisms.

Language: Английский

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