Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 117, P. 51 - 65

Published: Jan. 6, 2024

Microglia, resident immune cells in the central nervous system, play a role neuroinflammation and development of neuropathic pain. We found that stimulator interferon genes (STING) is predominantly expressed spinal microglia upregulated after peripheral nerve injury. However, mechanical allodynia, as marker pain following injury, did not require microglial STING expression. In contrast, activation by specific agonists (ADU-S100, 35 nmol) significantly alleviated male mice, but female mice. mice leads to increase proinflammatory cytokines may counteract analgesic effect ADU-S100. Microglial expression type I interferon-ß (IFN-ß) signaling were required for effects Mechanistically, downstream TANK-binding kinase 1 (TBK1) production IFN-ß, partly account observed. These findings suggest could be potential therapeutic intervention pain, particularly males.

Language: Английский

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STING in Cancer Immunoediting: Modeling Tumor-Immune Dynamics Throughout Cancer Development

Cancer Letters, Journal Year: 2025, Volume and Issue: 612, P. 217410 - 217410

Published: Jan. 16, 2025

Language: Английский

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Metabolic diseases and interferon immune responses

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Metabolic diseases, including obesity, diabetes, and metabolic‐associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed complex interplay between these metabolic disorders interferon (IFN) immune responses. As key regulators, interferons coordinate the host's defense against viral infections essential for maintaining homeostasis. However, dysregulation can significantly disrupt IFN signaling pathways, affecting intensity efficiency of Conversely, alterations in influence onset progression diseases. This review explores mechanisms by which diseases modulate responses, focusing on how MAFLD alter signaling. Additionally, we examine implications changes responses By synthesizing current research, this aims to elucidate offering insights future clinical applications field IFN‐related

Language: Английский

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Insulin-like growth factor binding protein 1 facilitates nervous necrosis virus replication through m6A methylation and suppression of antiviral immune response

Water Biology and Security, Journal Year: 2025, Volume and Issue: unknown, P. 100412 - 100412

Published: April 1, 2025

Language: Английский

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Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(11)

Published: Oct. 18, 2024

Language: Английский

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STING recognition of viral dsDNA by nociceptors mediates pain in mice

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 121, P. 29 - 42

Published: July 22, 2024

Pain is often one of the initial indicators a viral infection, yet our understanding how viruses induce pain limited. Immune cells typically recognize nucleic acids, which activate receptors and signaling, leading to immunity. Interestingly, these signals are also present in nociceptors associated with pain. Here, we investigate response acids during infections, specifically focusing on role signal, Stimulator Interferon Genes (STING). Our research shows that cytosolic double-stranded DNA (dsDNA) from viruses, like herpes simplex virus 1 (HSV-1), triggers responses through STING expression nociceptors. In addition, agonists alone can elicit responses. Notably, involve direct activation TRPV1. We provided proof-of-concept showing TRPV1 significantly contribute mechanical hypersensitivity induced by HSV-1 infection. These findings suggest could be potential therapeutic target for relieving infections.

Language: Английский

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STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: April 5, 2024

Language: Английский

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Revamping anti-cGAS-STING therapy via an injectable thermo-responsive supramolecular hydrogel for pathological retinal Angiogenesis

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100969 - 100969

Published: Sept. 23, 2024

Retinal neovascularization is a leading cause of blindness. While current anti-VEGF drugs effectively inhibit pathological angiogenesis, some patients develop resistance or reduced responsiveness to treatments over time, diminished effectiveness. In this study, we identified high activation the cGAS-STING signaling pathway, which exacerbated and vessel leakage. We developed an injectable thermo-responsive supramolecular hydrogel loaded with anti-STING drug. The hydrogel, made Pluronic F127 (PF·127) consisting poly(ethylene oxide) poly(propylene units, demonstrated excellent transparency biocompatibility. Importantly, thermo-sensitive property allowed for precise spatial release drug, extending effective treatment duration C-176, suppressed STING in retina, inflammation, protected retinal tissue. Hydro

Language: Английский

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Our understanding of microglia involvement in neuropathic pain has expanded

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 190 - 191

Published: March 3, 2024

Language: Английский

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Advance on the effects of algal carotenoids on inflammatory signaling pathways

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117020 - 117020

Published: Nov. 1, 2024

Language: Английский

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