Exosomal MicroRNAs as Brain Memory Devices DOI
Yoichi Robertus Fujii

Published: Jan. 1, 2023

MicroRNAs (miRNAs) have been implicated in brain memory mechanisms. miR-9c, miR-31a, miR-305, miR-974, and miR-980 were involved formation retention the Drosophila melanogaster central nervous system. Long-term was thought to exist as pattern strength of synaptic connections new maintenance neural circuits, but that circuit is distinct from memory. Of course, storage devices cannot work alone; they require compilers, processors. Memory contains source code, such computer binary representation code. Functional active regions play important roles CPU-like higher processing. According function, specific profiles miRNAs exhibited hippocampus cortex, which are plasticity formation. However, not itself; it just location part brain. Learning processes flexibility stability circuits because environmental inputs, high-order human behaviors learning depend on storage. far storing While large numbers neurons orchestrated connected with target where neuron cells reside, miRNA genes both glial become pools Several molecules, cAMP/protein kinase A (PKA), mitogen-activated protein (ERK/MAPK), mechanistic rapamycin (mTOR) signaling proteins, alpha-amino-3-hydroxyl-5-methyl-4-isoxazole propionate (NMDA/AMPA) receptors, calcium/calmodulin-dependent II (CaMKII), cAMP response element binding (CREB), tyrosine kinase, C (PKC), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3-K), circuits. these translated proteins failed retain store highly defined regulatory information upon their own synthesis control high-dimensional behavior. Given cell cascades underpin integration learning, hypothesis through nonspecific too impractical for mathematical algorithms information. In addition, environment has immeasurable effects neurotransmission. contrast, disease-specific can affect most biological pathways. This strongly suggests code within may also be maintained by several groups quantum factors. Thus, exogenous (exomiRNA) codes contained extracellular body fluids food-derived xenotropic (xenomiRNA) influence consciousness an environment. this chapter, we discovered therapeutic targets traumatic injury major depressive disorder entangling sorting (METS)/miRNA language artificial intelligence (MIRAI). Atrophin 1 (DRPLA, ATN1) enhanced downregulation miR-92a-1-5p hub injury. Neuregulin (NRG1) suppressed upregulation miR-1587 disorder.

Language: Английский

Unveiling the role of astrocytes in postoperative cognitive dysfunction DOI
Liang He,

X. Duan,

Shikuo Li

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102223 - 102223

Published: Feb. 5, 2024

Language: Английский

Citations

20
Exosomal circRNAs: Novel biomarkers and therapeutic targets for urinary tumors DOI
Qiang Liu, Shenglong Li

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216759 - 216759

Published: Feb. 28, 2024

Language: Английский

Citations

20
Long non-coding RNA-targeting therapeutics: discovery and development update DOI
Olga Khorkova, Jack Stahl,

Aswathy Joji

et al.

Expert Opinion on Drug Discovery, Journal Year: 2023, Volume and Issue: 18(9), P. 1011 - 1029

Published: July 19, 2023

Introduction lncRNAs are major players in regulatory networks orchestrating multiple cellular functions, such as 3D chromosomal interactions, epigenetic modifications, gene expression and others. Due to progress the development of nucleic acid-based therapeutics, potentially represent easily accessible therapeutic targets.Areas covered Currently, significant efforts directed at studies that can tap enormous potential lncRNAs. This review describes recent developments this field, particularly focusing on clinical applications.Expert opinion Extensive druggable target range lncRNA combined with high specificity accelerated process therapeutics open new prospects for treatment areas extreme unmet medical need, genetic diseases, aggressive cancers, protein deficiencies, subsets common diseases caused by known mutations. Although currently wide acceptance lncRNA-targeting is impeded need parenteral or direct-to-CNS administration, less invasive techniques orally available/BBB-penetrant showing early successes. Recently, mRNA-based COVID-19 vaccines have demonstrated safety all aspects technology, including chemical modifications acids nanoparticle delivery. These trends position drugs future drug development, especially area personalized medicine.

Language: Английский

Citations

15
The role of astrocyte in neuroinflammation in traumatic brain injury DOI Creative Commons
Liang He, Ruqiang Zhang,

Maiqiao Yang

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1870(3), P. 166992 - 166992

Published: Dec. 19, 2023

Language: Английский

Citations

13
Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions DOI
Li Zhang,

Wanshan Bai,

Lean Sun

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(7), P. 1997 - 2016

Published: Feb. 14, 2023

Language: Английский

Citations

11
Brain microvascular endothelial cell‐derived exosomes transmitting circ_0000495 promote microglial M1‐polarization and endothelial cell injury under hypoxia condition DOI
Xiaoli Min,

Wen‐ji Jia,

Li Guo

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(2)

Published: Jan. 9, 2024

Abstract Human brain microvascular endothelial cells (HBMVECs) and microglia play critical roles in regulating cerebral homeostasis during ischemic stroke. However, the role of HBMVECs‐derived exosomes polarization after stroke remains unknown. We isolated (Exos) from oxygen glucose deprivation (OGD)‐exposed HBMVECs, before added them into microglia. Microglia markers were tested using RT‐qPCR or flow cytometry. Inflammatory cytokines measured with ELISA. Endothelial cell damage was assessed by viability, apoptosis, apoptosis‐related proteins, oxidative stress, angiogenic activity CCK‐8, cytometry, western blot, ELISA, tube formation assay, respectively. also established middle artery occlusion (MCAO) mice model to examine function circ_0000495 on vivo. Our study found that HBMVECs‐Exos reduced M2 (IL‐10, CD163, CD206), increased M1 (TNF‐α, IL‐1β, IL‐12), CD86‐positive cells, inflammatory (TNF‐α IL‐1β), indicating promotion microglial M1‐polarization. Microglial M1‐polarization induced viability promoted apoptosis revealing aggravation damage. silencing inhibited HBMVECs‐Exos‐induced alterations. Mechanistically, adsorbed miR‐579‐3p upregulate toll‐like receptor 4 (TLR4) microglia; suppressed alterations via declining TLR4; furthermore, Yin Yang 1 (YY1) transcriptionally activated HBMVECs. Importantly, aggravated injury vivo activating TLR4/nuclear factor‐κB (NF‐κB) pathway. Collectively, OGD‐treated transmitted regulate miR‐579‐3p/TLR4/NF‐κB axis microglia, thereby facilitating

Language: Английский

Citations

4
Oxiracetam ameliorates neurological function after traumatic brain injury through competing endogenous RNA regulatory network DOI
Liyi Wang,

Han Guo,

Weidong Zhao

et al.

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

Citations

0
miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson’s disease models DOI Creative Commons

Xiang Tao,

Wenfei Zhang, Chen Chen

et al.

Aging, Journal Year: 2024, Volume and Issue: 16(10), P. 8732 - 8746

Published: May 21, 2024

Parkinson's disease (PD) is a neurodegenerative characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). This study focuses on deciphering role microRNA (miR)-101a-3p neuronal injury PD and its regulatory mechanism.

Language: Английский

Citations

3
miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response DOI
Priyajit Biswal, Anthony Lalruatfela, Subham Kumar Behera

et al.

IUBMB Life, Journal Year: 2023, Volume and Issue: 76(3), P. 108 - 124

Published: Oct. 4, 2023

Abstract MicroRNAs (miRNAs) are a class of noncoding RNAs about 19–25 nucleotides, which serve as critical modulators various cellular and biological processes by target gene regulation. Dysregulated expression miRNAs modulates the pathophysiology human diseases, including cancer. Among miRNAs, miR‐203a is one most extensively researched dysregulated in different cancers. Our review investigated roles hallmarks cancer modulating pathways through regulations, chemoresistance, its crosstalk with other ncRNAs or genes terms ceRNAs impacting oncogenesis, potential applications diagnosis, prognosis, chemotherapeutic responses types. impacts cell behavior regulating these exclusive hallmarks‐ sustaining proliferation, growth, invasion metastasis, death, angiogenesis. Besides, found circulating biofluids like plasma serum colorectal cancer, cervical hepatocellular carcinoma, hinting at biomarker. Further, involved enhancing chemosensitivity cisplatin, docetaxel, paclitaxel, doxorubicin, 5‐fluorouracil variety malignancies their cognate genes. These results suggest that crucial multifaceted miRNA controls chemotherapy response, shedding new light on possible application.

Language: Английский

Citations

7
Epigenetics and the neurodegenerative process DOI
Bartosz Słowikowski,

Wojciech Owecki,

J Jeske

et al.

Epigenomics, Journal Year: 2024, Volume and Issue: 16(7), P. 473 - 491

Published: March 21, 2024

Neurological diseases are multifactorial, genetic and environmental. Environmental factors such as diet, physical activity emotional state epigenetic factors. markers responsible for modifications. The effect of changes is increased inflammation the nervous system neuronal damage. In recent years, it has been shown that may cause an risk neurological disorders but, currently, relationship between modifications neurodegeneration remains unclear. This review summarizes current knowledge about caused by in Alzheimer's disease, Parkinson's stroke epilepsy. Advances techniques be key to understanding epigenetics central diseases.

Language: Английский

Citations

2