A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(1), P. 165 - 165
Published: Jan. 11, 2025
Fibromyalgia
represents
a
chronic
pain
disorder
characterized
by
musculoskeletal
pain,
fatigue,
and
cognitive
impairments.
The
exact
mechanisms
underlying
fibromyalgia
remain
undefined;
as
result,
diagnosis
treatment
present
considerable
challenges.
On
the
other
hand,
endogenous
opioid
system
is
believed
to
regulate
intensity
emotional
responses;
hence,
it
might
be
expected
play
key
role
in
enhanced
sensitivity
experienced
patients.
One
explanation
for
emergence
of
disrupted
modulation
individuals
with
significant
reduction
receptor
activity
or
an
imbalance
levels
peptides.
Further
research
essential
clarify
complex
details
this
abnormality.
This
complexity
arises
from
notion
that
improved
understanding
could
contribute
development
innovative
therapeutic
strategies
aimed
at
targeting
context
fibromyalgia.
Although
progress
being
made,
complete
these
complexities
remains
challenge.
paradigm
has
potential
revolutionize
management
fibromyalgia,
although
its
implementation
may
experience
effectiveness
approach
depends
on
multiple
factors,
but
implications
profound.
Despite
challenges
involved
transformation,
improving
patient
care
considerable,
condition
long
been
inadequately
treated.
Language: Английский
Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation
Frontiers in Pain Research,
Journal Year:
2025,
Volume and Issue:
6
Published: Jan. 31, 2025
Pain
management
remains
a
major
challenge
in
the
healthcare
system.
While
synthetic
analgesics
are
widely
used
for
pain
management,
their
effectiveness
managing
chronic
is
often
limited
due
to
low
efficacy
or
side
effects.
Thus,
there
growing
interest
exploring
alternative
relief
methods,
particularly
using
medicinal
plants
from
traditional
Eastern
medicine
and
phytochemicals.
Previous
studies
have
demonstrated
modulatory
effects
of
various
phytochemicals
derived
herbal
on
pain-related
ion
channels,
such
as
voltage-gated
sodium
channels
(Nav),
calcium
(Ca2+),
transient
receptor
potential
(TRP)
channels.
Since
these
integral
transmission
modulation
signals,
ability
specific
activate
inhibit
presents
promising
avenue
development
novel
analgesics.
The
goal
this
review
merge
insights
with
channel
research
highlight
natural
compounds
safe
effective
management.
In
regard,
we
summarize
discovery
characterization
pain-relieving
medicine,
discuss
mechanisms
action
mimic
enhance
conventional
through
modulation.
Language: Английский
Subcutaneous Injection and Brush Application of Ovalbumin–Aluminum Salt Solution Induces Dermatitis-like Changes in Mice
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(5), P. 1701 - 1701
Published: March 3, 2025
Background:
Intraperitoneal
sensitization
combined
with
topical
and/or
epicutaneous
treatment
using
an
ovalbumin
(OVA)–aluminum
salt
solution
(OVA-AL)
represents
a
model
for
inducing
atopic
dermatitis
(AD).
However,
the
combination
of
subcutaneous
and
cutaneous
application
OVA-AL
via
brush
has
not
been
explored
as
method
AD.
Methods:
Adult
mice
were
subcutaneously
injected
following
on
days
0,
7,
14
treated
to
dorsal
skin
fortnightly
until
35
49.
Concomitant
alloknesis
changes
assessed.
Mice
Balb/c
ICR-CD1
strains
day
35,
only
strain
continuing
Control
animals
received
saline.
At
49
days,
was
harvested
processed
histological
analysis.
Results:
developed
dry
skin,
no
scratching
or
alloknesis.
Histological
examination
revealed
increase
in
mast
cells
collagen
deposition.
Conclusions:
Dermatitis-like
symptoms
observed
this
administration
method.
Language: Английский
Physical TRPV1-PKR2 interaction modulates PKR2 localization, activation and β-arrestin-2 recruitment
Cellular Signalling,
Journal Year:
2025,
Volume and Issue:
unknown, P. 111761 - 111761
Published: March 1, 2025
Language: Английский
Spinal Cord Stimulation for Spinal Cord Injury-Related Pain: A Pilot Study
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1173 - 1173
Published: Nov. 22, 2024
Background:
Spinal
cord
stimulation
(SCS)
has
emerged
as
an
effective
treatment
for
managing
chronic
pain
that
is
unresponsive
to
traditional
therapies.
While
SCS
well
documented
conditions
like
failed
back
surgery
syndrome
(FBSS)
and
complex
regional
(CRPS),
its
effectiveness
in
related
spinal
injuries
(SCI)
less
studied.
This
study
aims
assess
the
efficacy
of
alleviating
SCI-related
improving
patients’
quality
life,
filling
a
gap
existing
literature.
Methods:
cohort
included
15
adult
patients
with
traumatic
non-traumatic
SCIs,
treated
between
2016
2022.
Patients
received
implants
after
either
trial
or
direct
implantation.
Pain
levels
were
assessed
using
visual
analog
scale
(VAS)
scores,
while
life
was
evaluated
EuroQol
five-dimensional
(EQ-5D)
scale.
The
devices
implanted
at
different
levels,
various
protocols
applied,
including
high-frequency
(10
kHz).
Results:
In
SCI,
mean
VAS
score
decreased
from
8.6
4.5,
71%
reporting
more
than
50%
relief.
Non-traumatic
SCI
experienced
reduction
8.5
2.5,
all
showing
EQ-5D
scores
improved
both
groups.
A
49%
medication
usage
also
observed,
though
one
patient
required
revision
due
adverse
event.
Conclusions:
significantly
reduces
improves
patients,
particularly
protocols.
promising,
further
research
needed
optimize
selection
parameters
better
long-term
outcomes.
Language: Английский