The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice DOI Creative Commons
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Recent studies indicate that oxidative/nitrosative stress is involved in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, and urticaria. The article aimed to review latest literature on disruptions redox homeostasis protein glycation allergy patients. It has been shown enzymatic non-enzymatic antioxidant systems are impaired conditions, which increases cell susceptibility oxidative damage. Reactive oxygen/nitrogen species exacerbate severity asthma symptoms by activating inflammatory mediators cause airway smooth muscle contraction, promote mucus hypersecretion, increase permeability lung capillaries, damage membranes. Redox biomarkers could have considerable diagnostic potential There no compelling evidence antioxidants reduce symptoms' or slow disease progression.

Language: Английский

The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice DOI Creative Commons
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Recent studies indicate that oxidative/nitrosative stress is involved in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, and urticaria. The article aimed to review latest literature on disruptions redox homeostasis protein glycation allergy patients. It has been shown enzymatic non-enzymatic antioxidant systems are impaired conditions, which increases cell susceptibility oxidative damage. Reactive oxygen/nitrogen species exacerbate severity asthma symptoms by activating inflammatory mediators cause airway smooth muscle contraction, promote mucus hypersecretion, increase permeability lung capillaries, damage membranes. Redox biomarkers could have considerable diagnostic potential There no compelling evidence antioxidants reduce symptoms' or slow disease progression.

Language: Английский

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