Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 168 - 168

Published: Jan. 22, 2025

The recent approval of lecanemab highlights that the amyloid beta (Aβ) protein is an important pathological target in Alzheimer’s disease (AD) and further emphasizes significance neuroinflammatory pathways regulating Aβ accumulation. Indeed, accumulation triggers microglia activation, which are key mediators neuroinflammation. inflammatory responses this process can lead to neuronal damage functional decline. Microglia secrete proinflammatory cytokines accelerate death release anti-inflammatory growth factors contributing recovery protection. Thus, play a dual role neurodegeneration neuroprotection, complicating their function AD. Therefore, elucidating complex interactions between protein, microglia, neuroinflammation essential for developing new strategies treating This review investigates receptors involved activating aims enhance understanding how these processes impact AD, as well they be regulated. also analyzed studies reported existing literature ongoing clinical trials. Overall, will contribute regulatory mechanisms therapies slow progression

Language: Английский

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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111218 - 111218

Published: Jan. 1, 2025

Language: Английский

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The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3015 - 3015

Published: March 26, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by cognitive decline, memory loss, and behavioural changes. While genetic predispositions pathological processes have been the traditional focus, this review highlights fundamental role of environmental factors, particularly nutrition, within exposome framework in modulating risk progression AD. The exposome, which includes totality exposures an individual's lifetime, provides comprehensive approach to understanding complex aetiology In review, we explore impact dietary factors cyclic nucleotide pathways (cAMP/cGMP) on AD, emphasizing potential interventions as therapeutic strategies. We investigate key aspects how nutrition affects accumulation β-amyloid, aggregation tau proteins, neuroinflammation. also examine specific nutrients performance Additionally, discuss nutraceuticals with anti-phosphodiesterase activity various animal models AD (such 5xFAD, 3xTg-AD, Tg2576, APP/PS1 mice) demonstrating effects onset progression.

Language: Английский

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The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 27, 2025

Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.

Language: Английский

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Evaluation of the Efficacy of a Full-Spectrum Low-THC Cannabis Plant Extract Using In Vitro Models of Inflammation and Excitotoxicity

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1434 - 1434

Published: Nov. 11, 2024

Evidence has accumulated that

Language: Английский

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