Harnessing stem cell-derived exosomes: a promising cell-free approach for spinal cord injury

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 17, 2025

Abstract Spinal cord injury (SCI) is a severe to the central nervous system that often results in permanent neurological dysfunction. Current treatments have limited efficacy and face challenges restoring function after injury. Recently, stem cell-derived exosomes gained attention as an experimental treatment for SCI due their unique properties, including superior biocompatibility, minimal immunogenicity non-tumorigenicity. With potential cell-free therapy, promote repair by enhancing nerve regeneration, reducing inflammation stabilizing blood-spinal barrier. This review summarizes advances exosome research over past years, focusing on mechanisms future prospects. Despite promising therapeutic potential, clinical translation remains challenging standardization of isolation protocols, compositional consistency long-term safety profiles require further investigation.

Language: Английский

Bone marrow mesenchymal stem cells-derived exosomal miR-24-3p alleviates spinal cord injury by targeting MAPK9 to inhibit the JNK/c-Jun/c-Fos pathway

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 769, P. 110434 - 110434

Published: April 22, 2025

Language: Английский