Parvalbumin Interneurons and Perineuronal Nets in the Hippocampus and Retrosplenial Cortex of Adult Male Mice After Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment DOI Creative Commons
Patrycja Klimczak, Arianna Rizzo, Esther Castillo‐Gomez

et al.

Frontiers in Synaptic Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Sept. 22, 2021

Both early life aversive experiences and intrinsic alterations in postnatal neurodevelopment are considered predisposing factors for psychiatric disorders, such as schizophrenia. The prefrontal cortex the hippocampus have protracted development affected schizophrenic patients. Interestingly, similar been observed retrosplenial (RSC). Studies patients animal models of schizophrenia found cortical parvalbumin (PV) expressing interneurons, making them good candidates to study etiopathology this disorder. Some PV+ interneurons may be mediated by perineuronal nets (PNNs), specialized regions extracellular matrix, which frequently surround these inhibitory neurons. In study, we used a double hit model (DHM) combining single perinatal injection an NMDAR antagonist (MK801) disturb post-weaning social isolation experience. We investigated PV PNNs RSC adult male mice, using unbiased stereology. CA1, but not CA3 region, hippocampus, number + PNN+ cells was drug treatment, significant decrease parameters groups animals that received MK801. percentage surrounding significantly decreased after treatment both hippocampal regions; however, impact only where isolated presented lower percentages. , effects isolation, MK801 interaction interventions on studied parameters; DHM, PV+, PNNs, PV+PNN+cells when compared control mice. Similar decreases were just or treated with To our knowledge, is first report neurodevelopmental during infancy/adolescence. These results show early-life events different regions, especially structure plasticity neurons their involvement emergence certain disorders.

Language: Английский

The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies DOI Creative Commons

Sophia Auer,

Martin Schicht, Lucas Hoffmann

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 321 - 321

Published: Feb. 20, 2025

Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability. This literature review aims to summarize current state knowledge about PNNs, their molecular composition structure, well functional roles involvement neurological diseases. Furthermore, future directions PNN research proposed, therapeutic potential targeting PNNs develop novel treatment options for various disorders is explored. emphasizes importance CNS physiology pathology underscores need further this area.

Language: Английский

Citations

0
Combined CSF1R Inhibition and Sensory Gamma Stimulation Provide Protective Effects in a Mouse Model of Alzheimers Disease DOI Creative Commons
Chinnakkaruppan Adaikkan, Md. Rezaul Islam, P. Lorenzo Bozzelli

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract The CSF1R inhibitor Plx3397, an FDA-approved treatment for a rare cancer, has been shown to reduce microglia, lower inflammation, and improve synaptic integrity in several mouse models of Alzheimer’s disease (AD). However, the effects Plx3397 on neural function AD remain largely unknown. Here, we used 5xFAD model characterize effect treatment. While administration increased density mice, it also reduced percentage neurons phase-locked gamma oscillations. This decoupling was closely associated with gene expression changes related synapse organization. These observations prompted us investigate whether gamma-frequency entrainment could counteract circuit alterations induced by administration. We thus enhanced phase-locking using non-invasive patterned sensory light stimulation. Remarkably, restoring oscillations improved function, reshaped signatures, learning memory Plx3397-treated mice. findings suggest that inhibitors like may benefit from multimodal approach combining microglial targeting stimulation support physiology cognitive AD.

Language: Английский

Citations

0
Nonneuronal contributions to synaptic function DOI
Ritchy Hodebourg, Michael D. Scofield, Peter W. Kalivas

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Perineuronal net degradation causes a delayed change in resting and sound evoked responses in the mouse auditory cortex DOI
Ahmed Hussain, Khaleel A. Razak

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Parvalbumin Interneurons and Perineuronal Nets in the Hippocampus and Retrosplenial Cortex of Adult Male Mice After Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment DOI Creative Commons
Patrycja Klimczak, Arianna Rizzo, Esther Castillo‐Gomez

et al.

Frontiers in Synaptic Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Sept. 22, 2021

Both early life aversive experiences and intrinsic alterations in postnatal neurodevelopment are considered predisposing factors for psychiatric disorders, such as schizophrenia. The prefrontal cortex the hippocampus have protracted development affected schizophrenic patients. Interestingly, similar been observed retrosplenial (RSC). Studies patients animal models of schizophrenia found cortical parvalbumin (PV) expressing interneurons, making them good candidates to study etiopathology this disorder. Some PV+ interneurons may be mediated by perineuronal nets (PNNs), specialized regions extracellular matrix, which frequently surround these inhibitory neurons. In study, we used a double hit model (DHM) combining single perinatal injection an NMDAR antagonist (MK801) disturb post-weaning social isolation experience. We investigated PV PNNs RSC adult male mice, using unbiased stereology. CA1, but not CA3 region, hippocampus, number + PNN+ cells was drug treatment, significant decrease parameters groups animals that received MK801. percentage surrounding significantly decreased after treatment both hippocampal regions; however, impact only where isolated presented lower percentages. , effects isolation, MK801 interaction interventions on studied parameters; DHM, PV+, PNNs, PV+PNN+cells when compared control mice. Similar decreases were just or treated with To our knowledge, is first report neurodevelopmental during infancy/adolescence. These results show early-life events different regions, especially structure plasticity neurons their involvement emergence certain disorders.

Language: Английский

Citations

21