Gating of Memory to Behavior by the Locus Coeruleus

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 11, 2024

An essential function of memory is to guide behavior for survival and adaptation. While considerable knowledge has been accumulated on formation, much less understood about how retrieved memories direct behavior/action. In the auditory Pavolovian threat conditioning paradigm, retrieval conditioned activates dorsomedial prefrontal (dmPFC) neurons exhibiting transient responses (T-neurons), which activate both dmPFC sustained (S-neurons) locus coeruleus (LC) neurons. Auditory inputs S-neurons enable conversion from so that freezing durations match those cues. Activation LC required by enhancing S-neuron responses, which, interestingly, opens a short time window during non-conditioned cues also lead freezing. The transition thus hinges integration memory, sensory inputs, emotional/body state generate selective, adequate, finely tuned behavior.

Language: Английский

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Noradrenergic and Dopaminergic Neural Correlates of Trait Anxiety: Unveiling the Impact of Maladaptive Emotion Regulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Background Maladaptive emotion regulation plays a crucial role in the development and maintenance of elevated anxiety levels, both patients individuals with subclinical symptomatology. While pharmacological treatments for target dysregulation through dopaminergic, noradrenergic serotonergic systems, little is known about underlying mechanisms. Therefore, current study depicts association these neuromodulatory systems’ resting-state functioning trait-anxiety, investigating maladaptive regulation. Methods Amplitude low-frequency fluctuations (ALFF), fractional amplitude (fALFF), whole-brain functional connectivity (rs-FC) were obtained from ventral tegmental area (VTA), locus coeruleus (LC) dorsal raphe, correlated trait-anxiety self-reported (N = 60). Results Trait-anxiety was positively associated LC’s fALFF negatively VTA’s rs-FC left inferior parietal lobule (L-IPL) superior frontal gyrus (L-SFG). regions, fully mediating this association. VTA region, but not parietal, predicted its neural oscillations, an effect that paralleled by stronger dopaminergic innervation. Limitations Use external molecular datasets need replication patients. Conclusions Noradrenergic systems appear to contribute differently anxiety. noradrenaline likely acts more general mechanism, dysconnectivity frontoparietal control network may act as one mechanisms regulation, informing models on disorder development. Highlights shows positive activity emotional are linked VTA-frontoparietal mediates regulation’s Strength ALFF

Language: Английский

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Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity

Medical Hypotheses, Journal Year: 2024, Volume and Issue: unknown, P. 111486 - 111486

Published: Sept. 1, 2024

Language: Английский

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Stress, Behavior, and Immune Function

NeuroImmunoModulation, Journal Year: 2024, Volume and Issue: 31(1), P. 211 - 229

Published: Oct. 4, 2024

Background: From the original studies investigating effects of adrenal gland secretion to modern high-throughput multidimensional analyses, stress research has been a topic scientific interest spanning just over century. Summary: The objective this review was provide historical context for influential discoveries, surprising findings, and preclinical models in stress-related neuroimmune research. Furthermore, we summarize work present current understanding pathways their on immune system behavior. We focus recent demonstrating stress-induced changes within brain highlight microglia. Lastly, conclude with potential areas future investigation concerning microglia heterogeneity, bone marrow niches, sex differences. Key Messages: Stress is phenomenon that ties together not only central peripheral nervous system, but as well. cumulative can enhance or suppress function, based intensity duration stressor. These alterations are associated neurobiological changes, including structural remodeling neurons decreased neurogenesis, these contribute development behavioral cognitive deficits. As such, field revealed important insights into communication well molecular cellular mediators complex behaviors relevant psychiatric disorders.

Language: Английский

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The Role of Prefrontal Cortex and the Cell Cycle Regulation in Anxiety

Published: Nov. 28, 2024

Language: Английский

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