Navigating the frontiers of mineral absorption in the human body: Exploring the impact of probiotic innovations DOI Creative Commons

Indian Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 62(07)

Published: July 9, 2024

Essential minerals play a crucial role in diverse physiological processes, and their deficiencies can give rise to significant health challenges. Probiotics, residing as beneficial microorganisms the gut, have recently garnered attention for potential modulating mineral absorption alleviating deficiencies. However, difficulties arise from variability of probiotic strains, varying dosages, distinct composition individuals' gut microbiota, rendering it challenging establish universal guidelines. A more nuanced understanding these mechanisms holds key developing targeted interventions, ultimately optimizing fostering human health. This review explores complex relationship between probiotics assimilation essential such iron, calcium, selenium, zinc, magnesium, potassium, decoding how influence minerals. Further research on is necessary nutrient uptake informing personalized interventions support overall

Language: Английский

Vitamin D, Calcium to Magnesium, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Jan. 21, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its ironic impact parathormone (PTH) Gut further complicates this. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) Ca:Mg, facilitated by A model incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, addresses seemingly contradictory reports regarding calcium (Ca), efficacy proposed.

Language: Английский

Citations

0
Vitamin D, Calcium to Magnesium, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Feb. 2, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its ironic impact parathormone (PTH) Gut further complicates this. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) Ca:Mg, facilitated by A model incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, addresses seemingly contradictory reports regarding calcium (Ca), efficacy proposed.

Language: Английский

Citations

0
Vitamin D, Calcium to Magnesium Ratio, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Feb. 11, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its ironic impact parathormone (PTH) Gut further complicates this. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) Ca:Mg, facilitated by A model incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, addresses seemingly contradictory reports regarding calcium (Ca), efficacy proposed. balance Ca at heart global epidemic insulin resistance. reliable method estimating intracellular Mg++ primary goal paper awaken public inadequacy RDA RDAs Ca. Using generally accepted serum reference ranges, difference RBC plasma basic physiology, one can both uncover serious shortfall involving three unequivocally demonstrate significant health risks linked an out range Ca:Mg. Conclusions observational experimental.

Language: Английский

Citations

0
System Overview from Physiological and Pathological Standpoints DOI
Gustavo Rodrigues Pedrino,

Luíza Toubas Chaul,

Virgínia Farias Alves

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta‐Analysis of Randomized Clinical Trials DOI Creative Commons
Atefeh Zandifar, Rahim Badrfam, Mahdi Mohammaditabar

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Recent studies have emphasized the relationship between mental health and human intestine microbiota. In this study, we evaluate effect of consuming Biotics, on levels depression, anxiety, cognitive function. This meta-analysis adhered to Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) standards. We searched MEDLINE (PubMed), Cochrane Library, Scopus, Web Science, ClinicalTrials.gov. All full-text articles major reviews were manually additional studies. The initial analysis was based concept that Biotics causes changes in measured using various instruments. showed significantly reduced anxiety our study participants (SMD = 0.2894, Z 2.46, P 0.0139, I^2 92.4%). included 4295 samples (2194 experimental group 2101 control group). terms depression 0.2942, 2.13, 0.0335, 91.7%). 3179 (1603 1576 Regarding function, improved function 0.4819, 3.00, 0.0027, 77.9%). 915 (470 445 Our results indicate most recent support effectiveness probiotics reducing symptoms issues despite some discrepancies findings. People with mild may experience greater benefits from taking probiotics. PROSPERO registration ID: CRD42024589507.

Language: Английский

Citations

0
Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease Therapeutics DOI
Sakshi Anand, Pradeep Kumar,

Sevaram Singh

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: March 19, 2025

Language: Английский

Citations

0
Depressive disorder prevention by DIET crosslink: Diet, intestinal microbiota, enzyme and traits of metabolism DOI

Yuye Gao,

Tingting Zhou

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 150, P. 104596 - 104596

Published: June 14, 2024

Language: Английский

Citations

3
Lactobacillus rhamnosus: An Emerging Probiotic with Therapeutic Potential for Depression DOI Creative Commons
Jing Feng,

Qiuyu Cen,

Yi Cui

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107541 - 107541

Published: Dec. 1, 2024

Depression, a complex psychological disorder, involves multiple biological pathways in its pathogenesis. In recent years, the gut-brain axis theory has provided novel insights into pathogenesis of depression, particularly crucial role gut microbiota mood regulation. While there remains no universal consensus on most efficacious strains for depression treatment, Lactobacillus rhamnosus risen to prominence within realm probiotics potential positively modulate depressive symptoms. This review preliminarily explores clinical significance treatment and summarizes mechanisms by which treats including regulation microbiota, alterations gene expression, improvement intestinal barrier function, maintenance neurotransmitter balance, suppression inflammatory responses, modulation immune system, coping with oxidative stress, optimization metabolic processes. Future research needs further explore these combine them results optimize plans provide more effective options patients depression.

Language: Английский

Citations

1
The Effect of Probiotics on Obesity with Comorbid Depression: A Systematic Review and Meta-Analysis DOI
Liang Chen,

Jinhu Zhou,

Ting Xu

et al.

British Journal of Hospital Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Sept. 9, 2024

Aims/Background Obesity and depression frequently co-occur, the relationship between them is bidirectional. Being obese or overweight increases risk of depression, conversely, obesity overweight. Emerging clinical research has shown that probiotics may be effective in treating associated depression. Modulating gut microbiota with improve obesity-related but current evidence inconsistent. Methods We systematically searched PubMed, EMBASE, Web Science, Cochrane Library for randomized controlled trials examining adults. Mean difference (MD) scores probiotic placebo groups was pooled across studies using random-effects models. Heterogeneity assessed I 2 to explain heterogeneity meta-regression analysis. To detect publication bias included studies, a funnel plot, Begg Egger tests, were used. Possible moderators detected by subgroup sensitivity analyses, Galbraith graphic display study (GOSH) Leave-one-out Influence analyses performed assess sensitivity. Results Five (n = 488) included. Overall, did not significantly depressive symptoms versus (MD 0.08, 95% confidence interval [CI] −0.63 0.79, p 0.82). Considerable among observed (I 63%). In reduced as measured Edinburgh Postnatal Depression Scale −0.60, CI −1.17 –0.03, 0.04) no 0%). Probiotics also decreased after 12 weeks supplementation −0.78, −1.58 –0.01, 0.05) placebo. No found tests. The GOSH diagnostics revealed three outliers, clusters identified K-means, DBSCAN (Density-based spatial clustering applications noise algorithm), GMM (Gaussian Mixture Model) analyses. Conclusion obesity. However, beneficial effects short-term use probiotic. Additional rigorous are warranted elucidate therapeutic potential

Language: Английский

Citations

0
Magnesium and Longevity DOI Creative Commons
Patrick Chambers

Published: Nov. 1, 2024

Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. a required cofactor for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. in synthesis vitamin D melatonin activation five eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.

Language: Английский

Citations

0