The impact of food restriction on liver enzyme levels: a systematic review and meta-analysis DOI
Hang Huang,

Yunmei Qiu,

Anyang Tang

et al.

Nutrition Reviews, Journal Year: 2023, Volume and Issue: 81(8), P. 939 - 950

Published: March 1, 2023

Abstract Context The relationship between food restriction (FR) and liver enzyme levels, such as alanine transferase (ALT), aspartate (AST), γ-glutamyl (GGT), has not yet been confirmed. Objective A meta-analysis of research articles was conducted to investigate the association FR levels. Data sources PubMed, Web Science, Embase, Cochrane Library databases were screened for published up April 30, 2022. extraction Preferred Reporting Items Systematic Reviews Meta-Analyses statement methodology used search articles. Publication bias detected using Begg’s test. Finally, 17 trials involving 1982 participants that reported mean value, difference, standard deviation identified. analysis described weighted difference body mass index, weight, standardized (SMD) ALT, AST, GGT. reduction in ALT level observed after a intervention (total SMD, –0.36, 95% confidence interval [CI], –0.68 –0.05). GGT levels also decreased 4 studies –0.23; 95%CI, –0.33 –0.14). According subgroup analysis, serum AST medium-term (between 5 wk 6 mo) group (subtotal –0.48; –0.69 –0.28). Conclusion Existing evidence suggests dietary improves adult long-term maintenance healthy particularly real-world applications, necessitates additional consideration.

Language: Английский

Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials DOI Creative Commons
Mingli Sun, Wei Yao, Xiaoying Wang

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 70, P. 102519 - 102519

Published: March 11, 2024

Benefits of Intermittent fasting (IF) on health-related outcomes have been found in a range randomised controlled trials (RCTs). Our umbrella review aimed to systematically analyze and synthesize the available causal evidence IF its impact specific while evaluating quality.

Language: Английский

Citations

34
The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans DOI Creative Commons
Jorn Trommelen, Glenn A. A. van Lieshout, Jean Nyakayiru

et al.

Cell Reports Medicine, Journal Year: 2023, Volume and Issue: 4(12), P. 101324 - 101324

Published: Dec. 1, 2023

Language: Английский

Citations

35
Combined versus independent effects of exercise training and intermittent fasting on body composition and cardiometabolic health in adults: a systematic review and meta-analysis DOI Creative Commons
Mousa Khalafi, Michael Symonds, Aref Habibi Maleki

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 6, 2024

Abstract Introduction and aim Exercise training (Ex) intermittent fasting (IF) are effective for improving body composition cardiometabolic health overweight obese adults, but whether combining Ex IF induces additive or synergistic effects is less well established. We therefore, performed a systematic review meta-analysis to compare the combined versus independent of on in adults. Method An electronic search was conducted three main online databases including PubMed, Web Science, Scopus, from inception March 9, 2023 studies involving plus trials standalone and/or interventions Interventions had duration ≥ 2 weeks. Standardized (SMD) weighted mean differences (WMD) 95% confidence intervals were calculated order weight, mass index (BMI), fat lean (LBM), visceral fat, waist circumference. For health, outcomes included glucose, insulin, total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), high-density (HDL), systolic (SBP) diastolic (DBP) blood pressure, VO max/peak. Results decreased weight [WMD: -3.03 kg (95% CI: -3.44 -2.61), p = 0.001], BMI -1.12 kg.m -1.28 -0.95), [SMD: -0.72 -1.23 -0.21), 0.005], -0.34 -0.63 -0.05), 0.01], circumference -2.63 cm -4.16 -1.11), 0.001] more than alone. However, changes markers not significantly different when compared with alone, exception max/peak 0.55 0.14 0.97), 0.009]. Conclusion demonstrate that combination produces superior composition, could therefore be loss has no other markers.

Language: Английский

Citations

15
The effects of intermittent fasting on body composition and cardiometabolic health in adults with prediabetes or type 2 diabetes: A systematic review and meta‐analysis DOI
Mousa Khalafi, Aref Habibi Maleki, Michael Symonds

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(9), P. 3830 - 3841

Published: July 2, 2024

Abstract Aim To perform a meta‐analysis to investigate the effects of intermittent fasting (IF), as compared with either control diet (CON) and/or calorie restriction (CR), on body composition and cardiometabolic health in individuals prediabetes type 2 diabetes (T2D). Methods PubMed, Web Science, Scopus were searched from their inception March 2024 identify original randomized trials parallel or crossover designs that studied IF health. Weighted mean differences (WMDs) standardized 95% confidence intervals (CIs) calculated using random‐effects models. Results Overall, 14 studies involving 1101 adults T2D included meta‐analysis. decreased weight (WMD −4.56 kg [95% CI −6.23 −2.83]; p = 0.001), mass index (BMI; WMD −1.99 kg.m −2.74 −1.23]; glycated haemoglobin (HbA1c; −0.81% −1.24 −0.38]; glucose −0.36 mmol/L −0.63 −0.09]; 0.008), total cholesterol −0.31 −0.60 −0.02]; 0.03) triglycerides −0.14 −0.27 −0.01]; 0.02), but did not significantly decrease fat mass, insulin, low‐densitiy lipoprotein, high‐density blood pressure CON. Furthermore, −1.14 −1.69 −0.60]; 0.001) BMI −0.43 −0.58 −0.27]; affect lean visceral fat, HbA1c, lipid profiles pressure. Conclusion Intermittent is effective for loss specific markers T2D. Additionally, associated reduction CR, without glycaemic markers,

Language: Английский

Citations

11
Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials DOI Open Access
Sofia Tsitsou, Nikolaos Zacharodimos, Kalliopi‐Anna Poulia

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4778 - 4778

Published: Nov. 11, 2022

Time-restricted feeding (TRF) and Ramadan fasting (RF) have been recently associated with several health outcomes. However, it is not yet clear if they are superior to existing treatments in terms of glucose metabolism, insulin action, weight loss. This review aims summarize the current data on effects these regimes body weight, composition, glycemia. An electronic search was conducted PUBMED SCOPUS databases up August 2022. Twenty-four records met inclusion criteria underwent a risk-of-bias assessment. The main outcomes were: (a) TRF may result moderate loss individuals overweight/obesity; when combined caloric restriction, >5% initial (b) 14 h be as effective 16 loss, (c) lead improved sensitivity glycemic responses/variability throughout day overweight/obesity. Concerning RF, only two studies were available thus, conclusions drawn. an nutritional approach for amelioration control more long-term, well-designed needed.

Language: Английский

Citations

35
Mechanisms of ageing: growth hormone, dietary restriction, and metformin DOI
Jan Sher Khan,

Ida Pernicova,

Kiran Nisar

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(4), P. 261 - 281

Published: Feb. 24, 2023

Language: Английский

Citations

18
Effect of intermittent fasting on lipid biokinetics in obese and overweight patients with type 2 diabetes mellitus: prospective observational study DOI Creative Commons

Yasmin Atwa Mohamed,

Megahed Abouelmagd,

Aya Elbialy

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 3, 2024

Intermittent fasting (IF) is a commonly used dietary practice that alternates between periods of unrestricted consumption and abstinence from caloric intake. IF reduces intake along with metabolic switch utilization glucose to fatty acids ketones resulting in reduction adiposity subsequently insulin resistance. Thus, it has been hypothesized regimens can improve body composition obese overweight individuals. To assess the effect on lipid biokinetics patients type 2 diabetes (T2D). Thirty or T2D were recruited outpatient clinics at Specialized Medical Hospital, Mansoura University. Patients subjected time restricted for 16 h (from dawn sunset) during Ramadan. Anthropometric data measured participants before 3 weeks after Ramadan fasting. Fasting plasma (FPG), HbA1c, profile, leptin, beta hydroxybutyrate (βHB) high sensitive CRP levels 1 week 30 diabetic mean age 54.3 ± 7.2 years. 24 (80%) females. Obesity was diagnosed 27 cases (90%). The median duration 10 study showed statistically significant decrease post-fasting weight (BW), Body mass index (BMI), waist circumference (WC) & hip (HC). There low density lipoprotein (LDL-C), Total cholesterol (TC), leptin. also increase (HDL-C) βHB. No change found FPG, triglycerides (TG) CRP. Post-fasting leptin positively correlated BW, BMI, WC, HC. βHB TG, LDL-C. Leptin (pre vs post fasting) LDL-C levels. reduced increased β-hydroxybutyrate an effective tool losing visceral fat improving profile T2D.

Language: Английский

Citations

6
Does intermittent fasting impact mental disorders? A systematic review with meta-analysis DOI
Rubén Fernández‐Rodríguez, Vicente Martínez‐Vizcaíno, Arthur Eumann Mesas

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(32), P. 11169 - 11184

Published: June 17, 2022

Accumulating evidence supports the benefits of intermittent fasting (IF) as a dietary strategy for cardiometabolic health and weight control. However, little is known about potential implications IF on mental disorders. The aim this review was to synthesize regarding effects disorders (depression, anxiety, mood state) in general population. We conducted systematic search five databases from inception January 2022. Randomized nonrandomized clinical trials (RCTs/nonRCTs) were included. A random method used pool standardized mean differences (SMDs) 95% CIs. total 14 studies involving 562 individuals included, which 8 RCTs 6 nonRCTs. showed moderate positive effect depression scores when compared control groups (SMD: 0.41; 95%CI: 0.05 0.76; I2=45%; n = 4). Conversely, within-group analyses did not show any significant anxiety 0.10; -0.09 0.30; I2=0%; 5) or state 0.14; 0.37; I2=59%; 7). modalities negatively impact In fact, influence diminishing scores, modify mood.

Language: Английский

Citations

26
Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease DOI Creative Commons
Georg Semmler, Christian Datz, Michael Trauner

et al.

Clinical and Molecular Hepatology, Journal Year: 2022, Volume and Issue: 29(Suppl), P. S244 - S260

Published: Dec. 15, 2022

Nutrition and dietary interventions are a central component in the pathophysiology, but also cornerstone management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding how diet influences metabolism focusing on specific effects liver, we provide comprehensive overview concepts to counteract increasing burden NAFLD. Specifically, emphasize importance calorie restriction independently macronutrient composition together adherence Mediterranean low added fructose processed meat that seems exert favorable beyond restriction. Also, discuss intermittent fasting as type specifically tailored decrease fat content increase ketogenesis, awaiting future study results Finally, personalized recommendations could be powerful tools effectiveness NAFLD considering genetic background microbiome, among others.

Language: Английский

Citations

26
Intermittent Fasting and Its Effects on Weight, Glycemia, Lipids, and Blood Pressure: A Narrative Review DOI Open Access
Elie Naous, Angela Achkar,

Joanna Mitri

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3661 - 3661

Published: Aug. 21, 2023

Metabolic syndrome (MetS) has become a significant public health concern globally. Weight managementis crucial in controlling MetS risk factors, making energy balance and weight loss strategies important nutrition recommendations. Intermittent fasting (IF) gained traction as dietary approach for management cardiovascular reduction. However, the effects of IF on factors have been inconsistent previous studies. This review aims to summarize various types body mass index (BMI), glycemia, lipid profile, blood pressure, while providing insights into their clinical implications. A comprehensive search interventional studies meta-analyses was conducted, results were analyzed. The findings indicate that different lead mixed effects. Time-restricted eating (TRE) alternate-day (ADF) consistently showed decreases BMI, outcomes intermittent restriction (IER) more uncertain. glycemia profile also variable, with TRE ADF generally showing positive results. impact IER remained inconsistent. More research is needed understand long-term optimal implementation managing metabolic factors.

Language: Английский

Citations

16