Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

The burden of disease and death attributable to environmental pollution is a growing public health challenge worldwide, particularly in developing countries. While the adverse effects on oral have garnered increasing attention, comprehensive systematic assessment remains lacking. This article delves into intricate relationship between health, highlighting significant impacts various aspects such as dental caries, periodontal diseases, facial clefts, cancer, well other diseases. Our results suggested that secondhand smoke, particulate matters (PM) heavy metals are most important risk factors affecting health. Additional contributors, radiation pollutants, electronic cigarette, phthalates, gaseous air pesticides, solvents, wood dust, formaldehyde excessive fluoride were investigated, though evidence for their limited often inconclusive. review also explores potential mechanisms underlying these impacts, including microorganism, inflammation, oxidative stress, genetic influences, toxicant exposures from pollutants. For instance, PM2.5 may contribute caries by disrupting pH balance absorbing lead cadmium which been considered promoting elements. It associated with inflammatory responses tissue damage tissues causing potentially leading periodontitis. Drawing current evidence, it provides analysis associations, offering critical insights guide development preventive strategies interventions. findings highlight pressing need future research validate causal links diseases unravel biological mechanisms. Ultimately, greater attention must be directed toward addressing focus control reduction preventable risks safeguard broader scale.

Language: Английский

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Dietary vitamin B6 intake and stroke are negatively associated in adults: A cross-sectional study from the NHANES

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31125 - e31125

Published: May 1, 2024

The relationship between dietary vitamin B6 and stroke risk is controversial; thus, we analyzed their correlation using data from the National Health Nutrition Examination Survey (NHANES).

Language: Английский

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Nonlinear Association Between Blood Cadmium Levels and Periodontitis: A Cross-Sectional Study from NHANES 2011-2014

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Objectives: The relationship between blood cadmium levels and the risk of periodontitis remains unclear. This study aimed to explore association concentrations in a large sample U.S. population from 2011 2014. Methods: cross-sectional analyzed data 5,215 participants National Health Nutrition Examination Survey (NHANES) 2011-2014. Blood were exposure variable, was outcome variable. Multivariate logistic regression two-piecewise linear model used examine nonlinear periodontitis. Stratified analyses conducted identify subgroups at higher risk. Results: identified The threshold effect observed 0.37 µg/L 1.20 µg/L. When below µg/L, odds ratio (OR) for 0.88 (95% CI: 0.31, 2.48; p=0.81). For OR increased significantly 12.40 2.77, 55.57; p<0.001). exceeded decreased 0.45 0.06, 3.39; p=0.44). Conclusions: found adults. when

Language: Английский

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Micronutrients and the Periodontium: A Narrative Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

This is a comprehensive narrative assessment of micronutrient relevance for periodontal health. The periodontium crucial and intricate structure that supports the tooth within alveolar bone. Composed four tissues with distinct embryological origins- bone, cementum, gingiva, ligament - plays fundamental role in maintaining dento-alveolar function homeostasis. Periodontitis gaining attention due to its widespread occurrence worldwide. inflammatory condition disrupts balance between host immune response microbial virulence factors. Connective tissue production defenses require proteins Vegetable support health by promoting repair function, while excessive dietary fats can exacerbate inflammation increase risk disease (PD). Inflammation further compounded animal fats, which contribute PD. Omega-3 fatty acids are well-known their anti-inflammatory effects, help reduce inflammation. Adequate intake essential minerals vitamins required Vitamins K, D, A oral epithelial integrity, facilitating bone development, supporting overall maintenance. Inadequate calcium (Ca²⁺) magnesium (Mg²⁺) levels have been associated severe Antioxidants such as vitamin C alleviate tissues. As recognized dental professionals, nutritional status considerable an individual's developing

Language: Английский

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Associations Between Folate Intake, Serum Folate, and Stroke Risk: The Mediating Role of Dietary Inflammatory Index from NHANES 2007-2018

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108318 - 108318

Published: April 1, 2025

Language: Английский

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Association between serum uric acid, hyperuricemia and periodontitis: a cross-sectional study using NHANES data

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Aug. 30, 2023

Diabetes and other metabolic diseases have been linked to the development of periodontitis, but little research has done determine whether serum uric acid (SUA) levels hyperuricemia play a role. This study aimed investigate relationship between SUA, hyperuricemia, periodontitis.Using data from National Health Nutrition Examination Survey (NHANES) 2011-2014, we created nationally representative set. We used multivariable logistic regression models assess periodontitis presented odds ratios (OR) in women men, respectively.In women, adjusted showed that SUA (4.1-4.3mg/dl) was associated with higher (OR = 1.43; 95% confidence interval (CI):1.0 ~ 2.03, p 0.047) (≤ 3.3mg/dl) as reference. The risk tended increase slightly insignificantly increasing levels, adverse effects occurred only when increased certain level, then reached plateau. In OR values for (4.9-5.2mg/dl), (5.3-5.5mg/dl), (5.9-6.2mg/dl), (6.3-6.5mg/dl) were 0.66 (95% CI: 0.45 0.96, 0.029), 0.58 0.40 0.85, 0.006), 0.67(95% 0.47 0.97, 0.035), 0.67 0.99, 0.043), respectively, 4.3mg/dl) elevated are protective against there is range within which decreases, followed by non-significant tendency increase.The periodontitis. Future prospective longitudinal studies strategies required further confirm controlled treatment an effective adjunct systematic periodontal therapy can be diagnostic biomarker or progression

Language: Английский

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U‐shaped association between serum calcium and in‐hospital mortality in patients with congestive heart failure

ESC Heart Failure, Journal Year: 2024, Volume and Issue: 11(5), P. 2521 - 2530

Published: March 11, 2024

Abstract Aims Serum calcium level is widely used for evaluating disease severity, but its impact on clinical outcomes in patients with congestive heart failure (CHF) remains poorly understood. The aim of this study to investigate the relationship between serum levels and in‐hospital mortality CHF patients. Methods results We conducted a retrospective analysis utilizing data from Medical Information Mart Intensive Care database, encompassing cohort 15 983 This was stratified based their levels, primary objective being determination mortality. To assess admission mortality, we employed various statistical methodologies, including multivariable logistic regression models, generalized additive model, two‐piecewise linear subgroup analysis. Comparative reference group (Q3) revealed increased first quintile (Q1, lowest blood level) fifth (Q5, highest level), fully adjusted odds ratios 1.38 [95% confidence interval (CI): 1.13–1.68, P = 0.002] 1.23 (95% CI: 1.01–1.5, 0.038), respectively. A U‐shaped observed risk occurring at threshold 8.35 mg/dL. effect sizes corresponding CIs below above were 0.782 0.667–0.915, 0.0023) 1.147 1.034–1.273, 0.0094), Stratified analyses confirmed robustness correlation. Conclusions Our identifies association patients, notable inflection point Further investigation through prospective, randomized, controlled studies warranted validate findings presented study.

Language: Английский

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Association of individual and combined exposures of 10 metals with periodontitis: Results from a large population‐based study

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: 59(4), P. 669 - 678

Published: April 26, 2024

Abstract Aims To systematically investigate the association between individual and combined metal exposure periodontitis. Methods Data encompassing complete periodontal examinations detection in blood urine samples were procured from National Health Nutrition Examination Survey (NHANES) 2011–2014. Three statistical methods, namely weighted logistic regression, Bayesian kernel machine regression (BKMR), quantile sum (WQS) used to evaluate independent associations metals Results Elevated concentrations of cadmium (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 1.15–2.61) lead (OR: 1.17, 95 %CI: 1.02–1.34) exhibited a positive with periodontitis, even after adjusting for potential confounding factors. The BKMR WQS suggested that co‐exposure was also positively associated Moreover, estradiol albumin identified as mediators relationship index 10 periodontitis explaining 25.36% 2.02% relationship, respectively. Furthermore, generally consistent patterns mediating roles estrogen observed series sensitivity analyses. Conclusion This study provides evidence elevated levels cadmium, or mixture which may be partially mediated by sex hormones oxidative stress indicators.

Language: Английский

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The Impact of Heavy Metal Contamination in Humans and Periodontitis: A Scoping Review

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский

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A pro-inflammatory diet is associated with an increased odds of periodontitis: finding from a case–control study

BMC Nutrition, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 27, 2023

This study aimed to evaluate the inflammatory effect of diet using dietary Inflammatory Index (DII) on odds periodontitis. We hypothesized that a with high DII scores (a pro-inflammatory diet) is associated chronic and systematic inflammation resulting in Periodontitis one most common diseases affect tissues around tooth results from interaction bacterial infection host immune response. The shows association between different food components level specific biomarkers.The intake 87 cases diagnosed periodontitis control was assessed 163-item valid frequency questionnaire (FFQ). calculated based FFQ data. Logistic linear regression models adjusting for multivariable confounders were used investigate ratio (OR) 95% confidence intervals (CI) developing periodontitis.There significant difference mean micronutrients groups, including saturated fatty acids (SFAs), iron, magnesium, manganese, vitamin C, crude fiber, selenium, chromium, whole caffeine, dairy, meat, patients group (p-value˂0.05). this ranged -3.13 + 0.99. However, OR raw multivariable-adjusted not statistically (multivariable-adjusted tertiles 1 vs. 3 = 2.00, 95%CI: 0.4-90.42, p-value 0.08). A similar result also observed continuous model 1.93, 0.30-98.79, 0.05).Although models, trend found models. promising since first examine diet-induced dental disease. It advisable conduct additional studies sample sizes other designs, such as prospective studies.

Language: Английский

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