A Nonlinear Association of Serum Uric Acid with All-cause and Cardiovascular Mortality among Patients with Cardiovascular Disease: A Cohort Study from NHANES
Abstract
Background
The
relationship
between
serum
uric
acid
(SUA)
and
mortality
in
patients
with
cardiovascular
disease
(CVD)
remains
controversial.
We
aimed
to
explore
the
SUA
all-cause
(ACM)
(CVM)
adult
CVD.
Methods
This
cohort
study
included
3977
CVD
from
National
Health
Nutrition
Examination
Survey
(2005–2018).
Death
outcomes
were
determined
by
linking
Index
(NDI)
records
through
December
31,
2019.
explored
association
of
using
weighted
Cox
proportional
hazards
regression
models,
subgroup
analysis,
Kaplan-Meier
survival
curves,
restricted
cubic
spline
(RCS)
threshold
effect
analysis
among
Results
During
a
median
follow-up
68
months
(interquartile
range,
34–110
months),
1,369
(34.4%)
3,977
died,
which
536
(13.5%)
died
deaths
833
(20.9%)
non-cardiovascular
deaths.
In
multivariable-adjusted
model
(Model
3),
risk
ACM
(HR
1.38,
95%
CI
1.16–1.64,
p
<
0.001)
CVM
1.40,
1.06–1.10,
for
participants
Q4
group
significantly
higher.
CVD,
RCS
revealed
nonlinear
(p
0.001
all
nonlinearities)
SUA,
ACM,
CVM.
Subgroup
showed
combined
chronic
kidney
(CKD),
thresholds
5.49
5.64,
respectively.
Time-dependent
ROC
curves
indicated
areas
under
curve
0.61,
0.60,
0.58,
0.55
1-,
3-,
5-,
10-year
0.69,
0.59,
0.56
CVM,
Conclusions
demonstrate
that
is
an
independent
prognostic
factor
supporting
U-shaped
mortality,
CKD,
nonlinear.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: June 18, 2024
Language: Английский