Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model DOI Creative Commons
Seyedeh Elnaz Nazari, Alex Tarnava,

Nima Khalili‐Tanha

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1436 - 1436

Published: Oct. 10, 2023

Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention treatment skeletal very crucial. This study aimed to investigate therapeutic potential hydrogen-rich water (HRW) on in unilateral hind limb immobilization model. Thirty-six male Balb/C mice were divided into control (without immobilization), atrophy, + (HRW). Unilateral was induced using splint 7 days (atrophy) removed 10 (recovery). At end each phase, gastrocnemius soleus weight, grip strength, histopathology, fiber size, cross-section area (CSA), serum troponin I IL-6, TNF-α Malondialdehyde (MDA), mRNA expression NF-κB, BAX Beclin-1 evaluated. Muscle weight strength H2-treated group significantly improved during this improvement continued recovery period. Treatment by HRW increased CSA size reduced fibrosis, I, MDA which more prominent phase. These data suggest that could improve an immobilized condition be considered rehabilitation.

Language: Английский

Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial DOI Creative Commons
Barbora Sládečková, Michal Botek, Jakub Krejčí

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed assess the effect of molecular administration on muscle performance, damage, perception soreness up 24 h recovery after two strenuous training sessions performed same day in elite fin swimmers. Methods: Eight females (mean ± SD; age 21.5 5.0 years, maximal oxygen consumption 45.0 2.5 mL.kg −1 .min ) four males (age 18.9 1.3 52.2 1.7 12 × 50 m sprints morning session a 400 competitive performance afternoon session. Participants consumed hydrogen-rich water (HRW) or placebo 3 days before (1,260 mL/day) 2,520 mL experimental day. Muscle (countermovement jump), damage (creatine kinase), (100 mm visual analogue scale) were measured during at Results: HRW compared reduced blood activity creatine kinase (156 63 vs. 190 64 U.L , p = 0.043), (34 42 mm, 0.045), improved countermovement jump height (30.7 5.5 cm 29.8 5.8 cm, 0.014) Conclusion: Four supplementation is promising hydration strategy for promoting Clinical Trial Registration: clinicaltrials.gov identifier NCT05799911

Language: Английский

Citations

6
Acute effect of hydrogen-rich water on physical, perceptual and cardiac responses during aerobic and anaerobic exercises: a randomized, placebo-controlled, double-blinded cross-over trial DOI Creative Commons
Nidhal Jebabli, Nejmeddine Ouerghi, Wissal Abassi

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 14, 2023

Molecular hydrogen (H2 gas) dissolved in water to produce Hydrogen-Rich Water. Water (HRW) is considered as ergogenic aid different exercise modes. However, acute pre-exercise HRW ingestion effect unclear regarding athlete performance. This study aimed at investigating of on aerobic and anaerobic Twenty-two male amateur middle-distance runners volunteered participate this study. In a randomized, double-blind design, all players ingested 500 mL or placebo (PLA) supplement 30 min before the start tests. Over 4 days, maximal speed Vameval test (MAS), time exhaustion MAS (Tlim), squat jump (SJ), counter-movement (CMJ) five (5JT) were evaluated. Also, rate perceived exertion (RPE) peak heart (HRpeak) measured during For test, improved MAS, HRpeak RPE compared with condition. Tlim demonstrated improvements exhaustion, HRpeak. no significant change was observed between HW conditions SJ, CMJ, 5JT. can significantly improve HRpeak, RPE, jumping performance endurance athletes.

Language: Английский

Citations

5
Effects of endurance exercise on physiologic complexity of the hemodynamics in prefrontal cortex DOI Creative Commons

Yinglu Hong,

Dapeng Bao, Brad Manor

et al.

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(01)

Published: March 21, 2024

Prefrontal cortex (PFC) hemodynamics are regulated by numerous underlying neurophysiological components over multiple temporal scales. The pattern of output signals, such as functional near-infrared spectroscopy fluctuations (i.e., fNIRS), is thus complex. We demonstrate first-of-its-kind evidence that this fNIRS complexity a marker captures the influence endurance capacity and effects hydrogen gas (

Language: Английский

Citations

1
Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis DOI Creative Commons
Yiting Li,

R. F. Bing,

Meng Liu

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 25, 2024

Objective Exercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H 2 ) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced stress, that is, increasing or decreasing stress. Therefore, we here conducted a systematic review and meta-analysis to quantitatively assess influence of H in healthy adults. Methods We publications across five databases. The following keywords were used for search strategy: [“hydrogen”[Mesh] “molecular hydrogen” “hydrogen rich water” “hydrogen-rich saline”] [“Oxidative Stress”[Mesh] “Antioxidative Stress” “Oxidative Damage” Injury” Cleavage”] [“randomized controlled trial”[Mesh] “randomized” “RCT”]. included trials reporting effects potential antioxidant capacity post-exercise Additionally, subgroup analyses explore how various elements intervention design affected those outcomes. Results Six studies, encompassing seven experiments with total 76 participants, our analysis. Among these hydrogen-rich water, hydrogen bathing, gas three forms administration. was applied different timing, including before, during, after only, both before exercise, repeatedly over days. Single-dose, multi-dose within 1 day and/or multiple-dose days implemented. It compared placebo, (diacron-reactive oxygen metabolites, d-ROMs) not significant (SMD = −0.01, 95%CI-0.42 0.39, p 0.94). However, induced greater improvement (Biological Antioxidant Potential, BAP) 0.29, 95% CI 0.04 0.54, 0.03) as placebo. Subgroup revealed supplementation showed 0.52, 95%CI 0.16 0.87, 0.02) intermittent exercises than continuous exercise. Conclusion help enhance adults, especially directly diminish levels Future more rigorous are needed examine confirm findings. Systematic registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364123 , Identifier CRD42022364123.

Language: Английский

Citations

1
Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway DOI Creative Commons
Xue Gao,

Shiying Niu,

Lulu Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e30902 - e30902

Published: May 1, 2024

Radiotherapy has become a standard treatment for chest tumors, but common complication of radiotherapy is radiation lung injury. Currently, there still lack effective

Language: Английский

Citations

1
Autonomic Cardiac Regulation in Response to Exercise and Molecular Hydrogen Administration in Well-Trained Athletes DOI
Michal Botek, Jakub Krejčí, Barbora Sládečková

et al.

Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 69 - 91

Published: Jan. 1, 2024

Language: Английский

Citations

0
Homeostatic and Endocrine Response Underlying Protective Effects by Molecular Hydrogen DOI
Mami Noda,

Eugene Iv. Nazarov

Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 113 - 123

Published: Jan. 1, 2024

Language: Английский

Citations

0
Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training DOI Creative Commons
Kaixiang Zhou,

Chaoqun Yuan,

Zhangyuting Shang

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 7, 2024

Background Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant anti-inflammatory properties of molecular hydrogen (H 2 ) highlight its potential to be as an effective nutritional supplement support performance healthy adults. However, the effects H supplementation on endurance trained individuals have not been well characterized. This study aimed assess intermittent hydrogen-rich water (HRW) before, during, after resistance training performance, neuromuscular status, subjective perceptual responses a 48-h recovery period. Methods randomized, double-blinded, placebo-controlled cross-over included 18 men aged 19.7 ± 0.9 years. Participants this were instructed consume 1,920 mL HRW or pure (Placebo) daily for 7 days. Additionally, participants required with five times during day (1,260 total). drinking 210 30 min 1 before training, between sets, immediately 420 into performed half-squat exercises load set at 70% one repetition maximum six sets (half-squat exercise repetitions failure each set). We measured power output number free barbell used participants. countermovement jump (CMJ) height, total quality scale (TQRS), muscle soreness visual analog (VAS) scores fatigue status 24 48 h recovery. Results (HRW: 50,866.7 6,359.9W, Placebo: 46,431.0 9,376.5W, p = 0.032) (HRW:78.2 9.5 repetitions, 70.3 0.019) supplemented group significantly higher than placebo group. there was no statistically significant difference (p< 0.05) groups CMJ, TQRS, VAS. Conclusion Eight days intake could improve individuals, making it promising strategy athletes fitness enthusiasts looking boost competitions. should noted that alone may adequate accelerate from following high-intensity training.

Language: Английский

Citations

0
Hydrogen therapy from the initiation to its practical applications DOI Creative Commons
Shigeo Ohta

PULMONOLOGIYA, Journal Year: 2024, Volume and Issue: 34(5), P. 624 - 633

Published: Oct. 10, 2024

Molecular hydrogen (H 2 ) has emerged as a therapeutic and prophylactic agent devoid of adverse effects. H demonstrates multifaceted functionality across diverse cell types organs, attributable to its interaction with oxidized hemes fundamental molecular mechanism. Given the abundance various heme both intracellularly extracellularly, broad-ranging effects are comprehensible. Subsequent Pathways mediated by end-or modified- products lipid peroxide followed free radical chain reactions. Notably, confers benefits not only patients afflicted diseases but also individuals seeking enhance health wellness. The mission medicine encompasses addressing unresolved medical challenges, including cerebral infarction, post-cardiac arrest syndrome, advanced cancer, metabolic dementia. Transitioning from animal experiments clinical studies is imperative confront these formidable effectively.

Language: Английский

Citations

0
The impact of hydrogen-rich water consumption to acute and residual fatigue after simulated football match: Study protocol for randomized, double blinded, placebo-controlled parallel trial (Preprint) DOI
Michal Hrubý, Karel Hůlka

Published: Dec. 6, 2024

BACKGROUND IFootball matches induce acute and residual fatigue, impairing neuromuscular, metabolic, perceptual performance. Hydrogen-rich water (HRW) is a novel intervention with antifatigue antioxidative properties. OBJECTIVE This study will investigate the effects of pre-exercise HRW administration versus placebo on performance, biochemical markers, measures fatigue during 72-hour recovery after simulated football match. METHODS Utilizing randomized, double-blinded, placebo-controlled, parallel design, elite junior players underwent assessments repeated sprint ability, countermovement jump indicators (e.g., creatine kinase levels). Testing be conducted immediately post-match at 24-, 36-, intervals. Pre- post-exercise HRW/placebo was administered under standardized conditions. RESULTS assess influence molecular hydrogen to manifestation quality We expect recruitment begin spring 2025, data analysis in summer results by end 2025. CONCLUSIONS The possible positive effect would speed up players' readiness train CLINICALTRIAL not clinical study.

Language: Английский

Citations

0