Racial and Ethnic Disparities in NAFLD: Harnessing Epigenetic and Gut Microbiota Pathways for Targeted Therapeutic Approaches DOI Creative Commons
Mohamed Zaiou, Olivier Joubert

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 669 - 669

Published: May 5, 2025

Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern, impacting approximately 32.4% of the worldwide population. As linked to metabolic dysfunction, NAFLD continues rise alongside increases in obesity, type 2 diabetes mellitus (T2DM), and syndrome. There considerable evidence indicating that disproportionately affects racial, ethnic, minority groups, although exact reasons for these disparities remain elusive. Contributing factors this may include socioeconomic status, cultural influences, stress, genetic factors, lifestyle choices. Emerging suggests causal could influence epigenetic mechanisms, particularly DNA methylation histone modifications, as well composition diversity gut microbiota. Nevertheless, there scarcity research comprehensively examines interplay between changes microbiome variations relation across different racial ethnic populations globally. This paper intends (i) explore connections NAFLD, disparities, microbiota composition, alterations, while reviewing pertinent studies illustrate how contribute inequities among various groups impacted by disease; (ii) potential therapeutic targets biomarkers advance management NAFLD; (iii) provide insights enhance our understanding mechanisms associated with disease, thereby promoting further field. Advancements area are anticipated susceptibilities at-risk new options its complications.

Language: Английский

Effects of dietary live microbes intake on a newly proposed classification system for steatotic liver disease DOI Creative Commons

Zhikun Dai,

Zian Bao,

Hanyuan Lin

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 15, 2025

Language: Английский

Citations

0
Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway DOI Creative Commons
Hui Chen, Ting Cao,

Chenquan Lin

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Akkermansia muciniphila (AKK), classified as “lean bacteria,” has emerged a promising candidate for ameliorating metabolic disorders, including obesity, diabetes, and liver disease. In this study, we investigated the therapeutic potential of AKK to counteract dysfunctions induced by Olanzapine (OLZ), first-class antipsychotic known its high efficacy but also association with disturbances, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Previous studies have implicated progesterone receptor membrane component 1 (PGRMC1) key player in antipsychotic-induced side effects. Using male C57BL/6J mice fed high-fat diet, assessed effects supplementation on OLZ-induced disturbances. Key parameters such body weight, hepatic injury markers, glucose tolerance, insulin resistance, lipid metabolism were analyzed. The study revealed that reduced accumulation, oxidative stress, while normalizing metabolism. These are likely mediated through restoration PGRMC1/SIRT1/FOXO1 signaling pathway AKK. Additionally, changes gut microbiota composition, reduction pathogenic bacteria Lactococcus enrichment beneficial bacteria, observed. Overall, suggests MASLD modulating pathways, making it strategy managing patients receiving treatment.

Language: Английский

Citations

0
Gut Microbiota and Bile Acid Metabolism in the Mechanism of Ginsenoside Re Against Nonalcoholic Fatty Liver Disease DOI
Yanfang Zheng,

Jia‐Ying Chen,

Ying Zhang

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Gut microbiota and bile acid metabolism play crucial roles in the progression of nonalcoholic fatty liver disease (NAFLD). Early evidence demonstrates that Ginsenoside Re (Re) possesses pharmacological effects on NAFLD, but its mechanisms action are not well understood. This study aimed to investigate hepatic protective NAFLD elucidate relevant mechanisms. The treatments (10, 20, or 40 mg/kg) against high-fat diet-induced were initially tested male C57BL/6 mice. Then, a separate mouse group received with without antibiotics confirm regulatory role effect Re. Finally, another mice fecal transplantation (FMT) from initial experiment further mechanistic gut microbiota. significantly improved function by reducing lipid accumulation, injury hepatocyte steatosis, inflammation. protection was mediated regulation as evidenced restored intestinal barrier integrity, normalized Firmicutes/Bacteroidota ratio, enhanced abundances Adlercreutzia equolifaciens, reduced Faecalibaculum rodentium. Following that, total primary acids downregulated synthesis genes proteins such farnesoid X receptor cytochrome P450 family 7 subfamily A member 1. co-administration antibiotic cocktail counteracted NAFLD. Further, results obtained FMT animal confirmed Re's at least partly driven modulated salt hydrolase-related microbial genera alter pathways, thereby inhibiting progression.

Language: Английский

Citations

0
Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease DOI

Jiawei Yu,

Qi Zhao,

Peixi Li

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(16)

Published: April 25, 2025

Duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty disease (NAFLD). However, the specific metabolic contributions of DMA IRE NAFLD remain unclear. To assess feasibility and effectiveness rat models. Seven-week-old male Sprague-Dawley rats underwent after 8 weeks on high-fat diet. Two post-treatment, duodenal tissues blood samples were collected. We evaluated differences wall structure, deposition, enteroendocrine, claudin, zonula ocludens-1 mucosa. could be safely performed without bleeding, perforation, or stenosis. The duodenum healed well 2 was characterized by slimmer villi, narrower shallower crypts, thicker myenterons compared sham-control setting. Liver reduced serum index parameters considerably improved these improvements independent food intake weight loss. In addition, enteroendocrine parameters, such as levels mucosa, differed between different settings group. By altering permeability, simple ameliorated rats.

Language: Английский

Citations

0
Racial and Ethnic Disparities in NAFLD: Harnessing Epigenetic and Gut Microbiota Pathways for Targeted Therapeutic Approaches DOI Creative Commons
Mohamed Zaiou, Olivier Joubert

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 669 - 669

Published: May 5, 2025

Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern, impacting approximately 32.4% of the worldwide population. As linked to metabolic dysfunction, NAFLD continues rise alongside increases in obesity, type 2 diabetes mellitus (T2DM), and syndrome. There considerable evidence indicating that disproportionately affects racial, ethnic, minority groups, although exact reasons for these disparities remain elusive. Contributing factors this may include socioeconomic status, cultural influences, stress, genetic factors, lifestyle choices. Emerging suggests causal could influence epigenetic mechanisms, particularly DNA methylation histone modifications, as well composition diversity gut microbiota. Nevertheless, there scarcity research comprehensively examines interplay between changes microbiome variations relation across different racial ethnic populations globally. This paper intends (i) explore connections NAFLD, disparities, microbiota composition, alterations, while reviewing pertinent studies illustrate how contribute inequities among various groups impacted by disease; (ii) potential therapeutic targets biomarkers advance management NAFLD; (iii) provide insights enhance our understanding mechanisms associated with disease, thereby promoting further field. Advancements area are anticipated susceptibilities at-risk new options its complications.

Language: Английский

Citations

0