Detection of Heavy Metals and Investigation of Their Association with Risk Factors for Metabolic Disorders in a Pakistani Population DOI Creative Commons

Ali Feezan,

Samina Afzal,

Syed Muhammad Shoaib

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 7, 2023

Abstract Environmental exposure to heavy metals, such as lead (Pb) and nickel (Ni), has been implicated in the development of chronic metabolic diseases, including diabetes mellitus (DM). This cross-sectional study aimed evaluate detection PB Ni ground water by ICP-OES urine samples participants ICP-MS found association between Pb risk factors for DM disorders participants. A total 2688 were recruited from district Sargodha Punjab, Pakistan. Participants categorized into Pb-exposed Ni-exposed groups, further stratified diabetic non-diabetic subgroups. In groundwater, Except pH, levels dissolved solids, electrical conductivity, hardness, turbidity exceeded guidelines set World Health Organization (WHO) concentrations groundwater WHO area. While participants, measured samples, various biomarkers related DM, lipid profile, inflammation, oxidative stress, liver function, kidney function assessed. The results showed significantly higher both individuals compared healthy had than non-diabetics, similarly, diabetics non-diabetics. These findings suggest that may contribute DM. also revealed associated with disruptions biomarkers. exhibited elevated glycemic index markers, fasting blood glucose (FBG) glycated hemoglobin A1c (HbA1c). inflammatory C-reactive protein (CRP) interleukin-6 (IL-6). Both dyslipidemia, indicated cholesterol LDL levels. Furthermore, impair evidenced AST, ALT, creatinine urea nitrogen. was MDA. study's supported correlation analyses, which demonstrated significant associations urinary disorders. conclusion, this provides substantial evidence linking a Pakistani population. highlight need stricter regulations preventive measures reduce metal contamination environment safeguard public health. Future longitudinal studies interventions are warranted elucidate mechanisms underlying diseases.

Language: Английский

Detection of Heavy Metals and Investigation of Their Association with Risk Factors for Metabolic Disorders in a Pakistani Population DOI Creative Commons

Ali Feezan,

Samina Afzal,

Syed Muhammad Shoaib

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 7, 2023

Abstract Environmental exposure to heavy metals, such as lead (Pb) and nickel (Ni), has been implicated in the development of chronic metabolic diseases, including diabetes mellitus (DM). This cross-sectional study aimed evaluate detection PB Ni ground water by ICP-OES urine samples participants ICP-MS found association between Pb risk factors for DM disorders participants. A total 2688 were recruited from district Sargodha Punjab, Pakistan. Participants categorized into Pb-exposed Ni-exposed groups, further stratified diabetic non-diabetic subgroups. In groundwater, Except pH, levels dissolved solids, electrical conductivity, hardness, turbidity exceeded guidelines set World Health Organization (WHO) concentrations groundwater WHO area. While participants, measured samples, various biomarkers related DM, lipid profile, inflammation, oxidative stress, liver function, kidney function assessed. The results showed significantly higher both individuals compared healthy had than non-diabetics, similarly, diabetics non-diabetics. These findings suggest that may contribute DM. also revealed associated with disruptions biomarkers. exhibited elevated glycemic index markers, fasting blood glucose (FBG) glycated hemoglobin A1c (HbA1c). inflammatory C-reactive protein (CRP) interleukin-6 (IL-6). Both dyslipidemia, indicated cholesterol LDL levels. Furthermore, impair evidenced AST, ALT, creatinine urea nitrogen. was MDA. study's supported correlation analyses, which demonstrated significant associations urinary disorders. conclusion, this provides substantial evidence linking a Pakistani population. highlight need stricter regulations preventive measures reduce metal contamination environment safeguard public health. Future longitudinal studies interventions are warranted elucidate mechanisms underlying diseases.

Language: Английский

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