Interactive and joint effects of toxic metals and oxidative balance score on the risk of mortality in adults with NAFLD

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 293, P. 117958 - 117958

Published: March 1, 2025

High oxidative balance score (OBS) may mitigate inflammation levels and thereby alleviate the adverse health effects induced by toxic metals. We assessed independent, joint as well their interactions of metals OBS on mortality among individuals with non-alcoholic fatty liver diseases (NAFLD). Participants NAFLD from National Health Nutrition Examination Survey (NHANES) 1999-2018 were included. Mortality underlying causes death certain Death Index records through 31 December 2019. Cox regression models used to estimate hazard ratios (HRs) for all-cause disease-specific mortality. Additionally, we multiplicative additive Among 5263 patients NAFLD, 1097 deaths occurred during a mean follow-up 10.27 years. Compared those in tertile 1, participants 3 had lower risk (HR=0.79, 95 %CI: 0.64, 0.96). lowest lead concentration blood, highest an increased mortality, HRs (95 %CIs) being 1.23 (1.01, 1.51), 1.53(1.06, 2.20) 1.94(1.25, 3.01) all-cause, CVD cancer respectively. Similar results also found blood cadmium level. Joint associations analyses that low high-OBS HRs(95 0.58(0.40, 0.85), 0.45(0.21, 0.93) 0.35(0.15, 0.81), Multiplicative between (HR=0.87, 0.78, 0.97) (HR=0.81, 0.67, 0.99) found. exposure associated NAFLD. Adopting anti-oxidative lifestyle could harmful patients. Comprehensive strategies are essential decrease potentially overall burden

Language: Английский

---

Oxidative balance score is independently associated with reduced prevalence of sarcopenia among US adults with metabolic syndrome

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

Background This research seeks to explore the link between oxidative balance score (OBS) and sarcopenia in American adults with Metabolic Syndrome (MetS) using data from a national, population-based survey. Methods The study included 3,625 participants diagnosed Syndrome, all aged 20 years above, derived NHANES datasets spanning 1999–2006 2011–2018. OBS evaluation was based on 16 dietary 4 lifestyle elements. MetS diagnosis followed NCEP-ATP III guidelines, while identification FNIH standards. We employed multivariate logistic regression analyses delve into connections within cohort. Results Sarcopenia found 17.46% of participants. In models adjusted for variables, OBS, each showed significant inverse relationship among individuals [OBS: OR = 0.959, 95%CI: (0.948, 0.982), P trend 0.0005; OBS: 0.963, (0.939, 0.989), 0.0055; 0.860, (0.787, 0.939), 0.0011]. Higher scores were consistently linked decreased incidence (all < 0.05). Restricted cubic spline analysis confirmed that these relationships linear. impact age significant, benefits only observed those 40 older. Conclusions Maintaining diet rich antioxidants is both independently collectively lower occurrence MetS. These results bolster proposition developing OBS-centered preventive strategies patients, particularly

Language: Английский

---

Higher oxidative balance score is linearly associated with reduced prevalence of chronic kidney disease in individuals with metabolic syndrome: evidence from NHANES 1999–2018

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 30, 2024

Background Oxidative stress is a key contributor to the development of chronic kidney disease (CKD) in individuals with metabolic syndrome (MetS). The oxidative balance score (OBS) an emerging composite assessment tool for dietary and lifestyle balance. We aimed explore association OBS CKD prevalence MetS this national cross-sectional analysis. Methods This was Eligible participants ≥20 years age from NHANES 1999–2018 were included. assessed according previous well-validated methods consisted 16 components 4 components. diagnosed by NCEP-ATP III criteria, while KDIGO 2021 Clinical Practice Guideline. Multivariate logistic regression models used Results A total 8,095 included, 24.8%. In fully adjusted models, each increases OBS, associated 2, 1.7, 7.3% reduction CKD, respectively. Higher all significantly lower odds ( p trend <0.05). Restricted cubic spline analysis showed that these associations exhibited inverse dose–response. Interaction analyses indicated cardiovascular (CVD) status influenced impact only present CVD-free subjects. Defining using IDF criteria did not change results. Conclusion inversely MetS, especially settings. These findings emphasize adherence antioxidant diet contributes early prevention population necessitates attention CVD interactions. Future prospective cohort studies are needed confirm

Language: Английский

---

Association of the oxidative balance score with sarcopenia among young and middle-aged adults: findings from NHANES 2011–2018

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 4, 2024

Background Sarcopenia is associated with oxidative stress. The Oxidative Balance Score (OBS) commonly used to assess dietary and lifestyle exposure However, few studies in the literature have assessed correlation between sarcopenia OBS. Aim This study aimed association OBS among young middle-aged adults United States using data from National Health Nutrition Examination Survey (NHANES). Method Weighted logistic regression analysis was investigate based on NHANES 2011–2018. Subgroup analyses were performed observe consistency of outcomes, stability results tested sensitivity analyses. Result final sample included 5,525 American adults. A higher a lower risk sarcopenia. In fully adjusted model, second (odds ratio [OR]: 0.62, 95% confidence interval [CI]: 0.41, 0.94; p = 0.023), third (OR: 0.50; CI: 0.34, 0.74; < 0.001), highest quartiles 0.18; 0.11, 0.28; 0.001) risks when compared lowest quartile. consistent across both scores. Our subgroup revealed no significant differences subgroups variables interaction analysis. Sensitivity similar results. Conclusion showed that antioxidant may decrease developing Higher scores indicate greater protection against sarcopenia; however, further clinical are warranted confirm these findings.

Language: Английский

---

Association of oxidative balance score, cardiovascular, and all-cause mortality among patients with type 2 diabetes mellitus

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 20, 2024

Background To investigate the association between oxidative balance score (OBS), cardiovascular mortality (CVM), and all-cause (ACM) in type 2 diabetes mellitus (T2DM) patients. Methods We included 6,119 participants with T2DM from 2005-2020 National Health Nutrition Examination Surveys (NHANES). The status of CVM ACM was followed through December 31, 2019. Multivariable Cox regression models, Kaplan-Meier curves, log-rank test, restricted cubic spline regression, subgroup analysis, were used to evaluate relationship OBS, CVM, ACM. Results During a median 100.9 months follow-up, 1,790 cases had occurred, 508 which due disease. divided into four groups based on quartiles OBS. Participants Q4 tended be younger, financially better-off, married, highly educated, lower alcohol consumption rates, non-smokers, exhibited likelihood CVM. In multivariate compared patients Q4, those Q1 30% increased risk for (Q1, reference; HR: 0.70, 95%CI: 0.58-0.86) 43% 0.57, 0.36-0.88). models have no nonlinear survival curves showed that (log-rank P < 0.05). Conclusions find increase higher OBS Moreover, there are linear relationships ACM,

Language: Английский

---

Association of life’s essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 23, 2024

The American Heart Association has updated the cardiovascular health (CVH) assessment tool, referred to as Life's Essential 8 (LE8). Metabolic dysfunction-associated steatotic liver disease (MASLD) is now most common chronic worldwide and linked an elevated risk of mortality. We aimed explore association LE8 with all cause cause-specific mortality in MASLD a prospective cohort study. A total 10,050 participants from NHANES 2005–2018 dataset were included was evaluated by combining four behaviors factors, scores 0–49 categorized low CVH, 50–79 moderate 80–100 high CVH. In fully adjusted model, each one-point increase score corresponded 2.7, 1.6% decrease all-cause, CVD, cancer risk, respectively, people MASLD. Compared being moderate/high CVH negatively associated outcomes, while factors lost significant

Language: Английский

---

Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Importance: Oxidative stress is an important contributor to the progression of nonalcoholic fatty liver disease (NAFLD), however, relationship between Composite Dietary Antioxidant Index (CDAI) and NAFLD in US adult population remains unclear. Objective: To access whether CDAI associated with adults. Design, setting, participants: This population-based cross-sectional study used data on adults from National Health Nutrition Examination Survey (NHANES) 2005-2016 cycles. Data were analyzed January February 2024. Exposures: obtained dietary intake questionnaire. Main outcomes measures: The main outcome was which defined by score (USFLI) ≥ 30. Sampling weights calculated according NHANES guidelines. Results: Among 9746 included this (mean age, 48.3 years; 4662 [47.6%] males), 3324 (33.0%) classified as having using USFLI. In fully adjusted multivariable logistic regression, negative (odds ratio [OR], 0.95; 95% CI, 0.93-0.98). Furthermore, highest quartile 34% less likely have than those lowest (OR, 0.66; 0.52-0.85). subgroup analyses, among participants who male 0.94; 0.92-0.97), without diabetes 0.93-0.97), metabolic syndrome 0.93; 0.91-0.96). addition, correlation robust sensitivity analyses that excluded potential hepatotoxic medication use 0.93-0.98), or non-Hispanic Black based hepatic steatosis index (HSI) 0.97; 0.95-0.99), unweighted analysis 0.96; 0.94-0.98). Conclusions relevance: six cycles (2005-2016) NHANES, population. association may provide a new approach explore factors affecting interventions reduce incidence NAFLD.

Language: Английский

---

Interactive and Joint Effects of Heavy Metals and Oxidative Balance Score on the Risk of Mortality in Adults with Nafld

Published: Jan. 1, 2024

Language: Английский

---

Association between oxidative balance scores and severe abdominal aortic calcification in American adults: National health and nutrition examination survey

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 103697 - 103697

Published: July 1, 2024

Language: Английский

---

Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

Background Oxidative stress may be relevant in the progression and cardiovascular complications of prediabetes. The oxidative balance score (OBS) is an emerging metric for assessing dietary lifestyle exposure. objective this prospective cohort study from NHANES 1999–2018 was to explore association OBS with all-cause disease (CVD) mortality people Methods composed 16 components 4 based on previous research. Prediabetes diagnosed self-reported history or laboratory criteria. Multivariate Cox proportional hazards regression analyses were used these associations calculate hazard ratios [HR] 95% confidence intervals [CI]. Results A total 8256 adult participants prediabetes included. Kaplan-Meier survival analysis showed significantly higher CVD-related at OBS. After adjusting all confounders, OBS, inversely associated (HR CI 0.959 (0.946,0.973), 0.965 (0.950,0.980), 0.847 (0.798,0.899), respectively; p < 0.0001). Higher lower (p trend Similar results observed CVD mortality. Most linear, whereas nonlinear. Mediation suggested that several systemic inflammatory markers mediated associations. Stratified sensitivity demonstrated stability findings. Conclusions Adherence antioxidant patterns assessed by help prevent excess population These effects achieved indirectly influencing markers.

Language: Английский

---