Exploring causal associations of antioxidants from supplements and diet with attention deficit/hyperactivity disorder in European populations: a Mendelian randomization analysis DOI Creative Commons
Jing Chen, Lifei Chen,

Xinguang Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 24, 2024

Background Antioxidants from both supplements and diet have been suggested to potentially reduce oxidative stress in individuals with ADHD. However, there is a lack of studies utilizing the Mendelian randomization (MR) method explore relationship between dietary supplemental antioxidants Methods This study employed two-sample mendelian randomization. Various specific antioxidant (such as coffee, green tea, herbal standard red wine intake per week), along diet-derived circulating including Vitamin C (ascorbate), E ( α -tocopherol), γ carotene, A (retinol), zinc, selenium N = 2,603–428,860), were linked independent single nucleotide polymorphisms (SNPs). Data on ADHD was gathered six sources, comprising 246,888 participants. The primary analytical utilized inverse variance weighting (IVW), sensitivity analysis conducted assess robustness main findings. Results In different diagnostic periods for ADHD, we found that only tea among significantly associated reduced risk males (OR: 0.977, CI: 0.963–0.990, p < 0.001, FDR 0.065), no evidence pleiotropy or heterogeneity observed results. Additionally, nominal causal association childhood 0.989, 95% 0.979–0.998, 0.023, 0.843). No relationships detected other antioxidant-rich diets Conclusion Our significant male suggesting higher consumption may males. Further research needed optimal doses underlying mechanisms.

Language: Английский

Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature DOI Open Access
Michael J. Diaz,

Jasmine Tran,

D W Rose

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 357 - 357

Published: Jan. 20, 2025

Vitiligo is a chronic autoimmune pigmentation disorder shaped by complex interplay of genetic predispositions and environmental triggers. While conventional therapies—phototherapy, corticosteroids, immunosuppressants—can be effective, their benefits are often partial temporary, with recurrence common once treatment stops. As such, there increasing interest in exploring complementary approaches that may offer more sustainable impact. Emerging evidence suggests macronutrient micronutrient-level changes could beneficial for managing progression and, some cases, facilitating repigmentation. Antioxidant-rich foods, such as apples, green tea, Indian gooseberry, onions, peppers, help mitigate oxidative stress, while inflammatory gluten high-phenol nuts berries, exacerbate the condition. Certain supplements, including high-dose vitamin D, C, E, selenium, enhance phototherapy outcomes. Omega-3 other unsaturated fatty acids, addition to prebiotics probiotics, under active investigation roles gut health immune regulation. Notably, plant-derived compounds, i.e., Ginkgo biloba, have demonstrated promise promoting repigmentation disease progression. However, it must emphasized these nutritional interventions remain exploratory, research needed establish efficacy, safety, optimal usage before they can recommended part standard regimen.

Language: Английский

Citations

1
Elucidating the relationship between metabolites and breast cancer: A Mendelian randomization study DOI

Yilong Lin,

Yue Zhang, Songsong Wang

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 484, P. 116855 - 116855

Published: Feb. 8, 2024

Language: Английский

Citations

4
Superior performance of nickel doped vanadium pentoxide nanoparticles and their photocatalytic, antibacterial and antioxidant activities DOI

A. Remila,

V. Shally,

C. Parvathiraja

et al.

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(7), P. 3009 - 3031

Published: May 31, 2024

Language: Английский

Citations

2
Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study DOI Creative Commons
Kexin Yuan, Xingwen Xie, Weiwei Huang

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Background Osteoporosis (OP) is typically diagnosed by evaluating bone mineral density (BMD), and it frequently results in fractures. Here, we investigated the causal relationships between diet-derived circulating antioxidants risk of OP using Mendelian randomization (MR). Methods Published studies were used to identify instrumental variables related absolute levels like lycopene, retinol, ascorbate, β-carotene, as well antioxidant metabolites such α-tocopherol, γ-tocopherol. Outcome included BMD (in femoral neck, lumbar spine, forearm, heel, total body, body (age over 60), 45–60), 30–45), 15–30), 0–15)), fractures arm, leg, osteoporotic fractures), OP. Inverse variance weighted or Wald ratio was chosen main method for MR analysis based on number single nucleotide polymorphisms (SNPs). Furthermore, performed sensitivity analyses confirm reliability findings. Results We found a relationship retinol heel ( p = 7.6E-05). The fixed effects IVW showed protective effect against BMD, with per 0.1 ln-transformed being associated 28% increase (OR: 1.28, 95% CI: 1.13–1.44). In addition, sex-specific has been observed men. No other significant found. Conclusion There positive BMD. implications our should be taken into account future creation public health policies prevention tactics.

Language: Английский

Citations

0
Exploring causal associations of antioxidants from supplements and diet with attention deficit/hyperactivity disorder in European populations: a Mendelian randomization analysis DOI Creative Commons
Jing Chen, Lifei Chen,

Xinguang Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 24, 2024

Background Antioxidants from both supplements and diet have been suggested to potentially reduce oxidative stress in individuals with ADHD. However, there is a lack of studies utilizing the Mendelian randomization (MR) method explore relationship between dietary supplemental antioxidants Methods This study employed two-sample mendelian randomization. Various specific antioxidant (such as coffee, green tea, herbal standard red wine intake per week), along diet-derived circulating including Vitamin C (ascorbate), E ( α -tocopherol), γ carotene, A (retinol), zinc, selenium N = 2,603–428,860), were linked independent single nucleotide polymorphisms (SNPs). Data on ADHD was gathered six sources, comprising 246,888 participants. The primary analytical utilized inverse variance weighting (IVW), sensitivity analysis conducted assess robustness main findings. Results In different diagnostic periods for ADHD, we found that only tea among significantly associated reduced risk males (OR: 0.977, CI: 0.963–0.990, p < 0.001, FDR 0.065), no evidence pleiotropy or heterogeneity observed results. Additionally, nominal causal association childhood 0.989, 95% 0.979–0.998, 0.023, 0.843). No relationships detected other antioxidant-rich diets Conclusion Our significant male suggesting higher consumption may males. Further research needed optimal doses underlying mechanisms.

Language: Английский

Citations

0