Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isolated mitochondria DOI
Ahmad Salimi, Saleh Khezri,

Zoleikhah Vahabzadeh

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(4)

Published: May 30, 2024

Abstract It has been reported that lipophilic statins such as atorvastatin can more readily penetrate into β‐cells and reach the mitochondria, resulting in mitochondrial dysfunction, oxidative stress, decrease insulin release. Many studies have shown natural products protect dysfunction induced by drug different tissue. We aimed to explore protection potency of hesperidin, vanillic acid, sinapic acid compounds against pancreas isolated mitochondria. Mitochondria were form rat directly treated with toxic concentration (500 µM) presence various concentrations (1, 10, 100 separately. Mitochondrial toxicity parameters reactive oxygen species (ROS) formation, succinate dehydrogenases (SDH) activity, swelling, depletion glutathione (GSH), membrane potential (MMP) collapse, malondialdehyde (MDA) production measured. Our findings demonstrated at 500 μM higher pancreatic Except MDA, caused significantly reduction SDH ROS GSH, collapse MMP. While, our data showed all three protective low ameliorated atorvastatin‐induced increase improvement MMP formation. conclude reverse which may be beneficial for diabetogenic‐induced β‐cells.

Language: Английский

Comparative Evaluation of the Antidiabetic potential of three varieties of Ipomoea batatas L. DOI Creative Commons
Seun F. Akomolafe, Oluwadamilare Ajayi, O. Agboola

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 102015 - 102015

Published: March 28, 2025

Sweet potato (Ipomoea batatas L.) is a nutrient-dense tuber often used in traditional diabetic treatment. This research compares the antidiabetic potential of three sweet varieties: orange-fleshed (OFSP), purple-peel white-fleshed (PPWSP), and white-peel (WPWSP), utilising vitro vivo techniques. potatoes (OFSP, PPWSP, WPWSP) boiled at 100°C for 20 minutes were incorporated into formulated diets administered to streptozotocin-induced rats 14 days. Aqueous extracts tested antioxidants phytochemicals. Glycaemic control parameters, lipid profiles, oxidative stress indicators, pancreatic histology investigated. Gene expression analysis was performed on critical diabetes-related pathways. OFSP showed significant strong anti-diabetic benefits, including better glycemic control, weight maintenance, lower HOMA-IR scores, lowered α-amylase α-glucosidase activity. OFSP-fed had higher insulin, glycogen, hexokinase activity than those given PPWSP WPWSP. decreased mRNA DPP-4 while increasing GLP-1 expression. also improved HDLc decreasing LDLc triglycerides more other varieties. Histopathological examination revealed restorative effects beta cells. demonstrated pronounced compared WPWSP, particularly terms insulin regulation, profile improvement. These findings suggest that may offer diabetes management. However, further clinical studies are needed validate these results explore practical dietary applications control.

Language: Английский

Citations

0
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2 DOI Creative Commons
Xiufang Chen, Qian Zhou, Huamin Chen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 400 - 400

Published: March 27, 2024

Glutathione (GSH), a robust endogenous antioxidant, actively participates in the modulation of redox status cysteine residues proteins. Previous studies have indicated that GSH can prevent β-cell failure and prediabetes caused by chronic oscillating glucose (OsG) administration. However, precise mechanism underlying protective effect is not well understood. Our current research reveals capable reversing reduction Nrf2 levels, as downstream genes Grx1 HO-1, islet β-cells rats induced OsG. In vitro experiments further demonstrated dedifferentiation, apoptosis, impaired insulin secretion Additionally, facilitates translocation into nucleus, resulting an upregulation Nrf2-targeted such GCLC, Grx1, NQO1. Notably, when inhibitor ML385 employed, effects on OsG-treated are abrogated. Moreover, enhances S-glutathionylation Keap1 at Cys273 Cys288, but Cys151, β-cells, leading to dissociation from facilitating nuclear translocation. conclusion, role against OsG-induced be partially attributed its capacity enhance S-glutathionylation, thereby activating signaling pathway. These findings provide novel insights prevention treatment context prediabetes/diabetes, highlighting potential GSH.

Language: Английский

Citations

3
Effects of Gossypetin on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats DOI Creative Commons
Karishma Naidoo, Andile Khathi

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4410 - 4410

Published: Sept. 17, 2024

Natural flavonoids exert many potential health benefits, including anti-hyperglycaemic effects. However, the effects of gossypetin (GTIN) on glucose homeostasis in pre-diabetes have not yet been investigated. This study examined GTIN key markers a diet-induced pre-diabetic rat model. Pre-diabetes was induced by allowing animals to feed high-fat high-carbohydrate (HFHC) diet supplemented with 15% fructose water for 20 weeks. Following induction, were sub-divided into five groups (

Language: Английский

Citations

2
Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isolated mitochondria DOI
Ahmad Salimi, Saleh Khezri,

Zoleikhah Vahabzadeh

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(4)

Published: May 30, 2024

Abstract It has been reported that lipophilic statins such as atorvastatin can more readily penetrate into β‐cells and reach the mitochondria, resulting in mitochondrial dysfunction, oxidative stress, decrease insulin release. Many studies have shown natural products protect dysfunction induced by drug different tissue. We aimed to explore protection potency of hesperidin, vanillic acid, sinapic acid compounds against pancreas isolated mitochondria. Mitochondria were form rat directly treated with toxic concentration (500 µM) presence various concentrations (1, 10, 100 separately. Mitochondrial toxicity parameters reactive oxygen species (ROS) formation, succinate dehydrogenases (SDH) activity, swelling, depletion glutathione (GSH), membrane potential (MMP) collapse, malondialdehyde (MDA) production measured. Our findings demonstrated at 500 μM higher pancreatic Except MDA, caused significantly reduction SDH ROS GSH, collapse MMP. While, our data showed all three protective low ameliorated atorvastatin‐induced increase improvement MMP formation. conclude reverse which may be beneficial for diabetogenic‐induced β‐cells.

Language: Английский

Citations

0