Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

The triglyceride glucose (TyG) index-related obesity indices have been proposed as reliable indicators of insulin resistance. This study aims to investigate the association between TyG and sarcopenia well their potential a tool for screening sarcopenic patients. A cross-sectional was conducted involving 7,161 participants aged 18 above from National Health Nutrition Examination Survey. index indices, including glucose-body mass (TyG-BMI), glucose-waist circumference (TyG-WC), glucose-waist-to-height ratio (TyG-WHtR) were determined using standard formulas. appendicular skeletal muscle BMI used assess sarcopenia. relationship investigated restricted cubic spline analysis multivariate logistic regression analysis. diagnostic value -related compared receiver operating characteristic (ROC) curve. In fully adjusted model, positive correlation observed TyG-WHtR (for each one-unit increase in index: OR = 3.57, 95% CI: 2.71–4.71, P < 0.001). Additionally, analyses demonstrated significant predictor with highest odds ratio, reaching 12.50 (95% 6.13–25.70, 0.001) upper fourth quartile (Q4) first quartile, followed by TyG-BMI (Q4: 3.34; 1.92–5.80, TyG-WC 1.95; 1.04–3.68, RCS curve fitting indicated U-shaped diagnosis sarcopenia, an inflection point at 4.02. Furthermore, ROC analysis, AUC largest (0.79, ndex-related especially TyG-WHtR, shown be more effective identifying patients than alone.

Language: Английский

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Association between lipid ratios and sarcopenia and the mediating roles of inflammatory biomarkers in a cross-sectional study from NHANES 2011–2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Sarcopenia, which leads to reduced quality of life and increased medical burden, is challenging diagnose in a timely manner. Lipid metabolism plays role sarcopenia, this study explored the associations between blood lipid profile parameters sarcopenia. Using data from National Health Nutrition Examination Survey 2011–2018, we conducted weighted multivariate logistic regression investigate ratios including non-high-density lipoprotein cholesterol (non-HDL-C) HDL-C, triglyceride (TG) low-density (LDL-C) remnant (RC) HDL-C ratios. We performed subgroup analyses assess interactions with other covariates used mediation models evaluate mediating roles inflammatory biomarkers. included total 9500 non-sarcopenic 849 sarcopenic participants aged 18–59 years. While observed modest correlations individual components obtained significant positive for Specifically, non-HDL/HDL-C (OR = 1.09; 95% CI 1.03–1.15; P 0.003), TG/HDL-C 1.02; 1.02–1.04; 0.014), LDL/HDL-C 1.27; 1.11–1.45; < 0.001), RC/HDL-C 1.55; 1.16–2.07; 0.004) showed strong These were more pronounced younger participants, those lower family economic status, without self-reported diabetes. Furthermore, there effects biomarkers on association non-HDL/HDL-C, LDL/HDL-C, sarcopenia risk, proportions ranging 2.90 6.36%. In conclusion, our demonstrated middle-aged adults, suggesting potential these improving case identification. Further research required explore underlying mechanisms.

Language: Английский

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Oxidative balance score is associated with increased risk of sarcopenia and sarcopenic obesity in non-elderly adults: results from NHANES 2011–2018

Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 11, 2025

Sarcopenia and obesity, two prevalent health conditions, often coexist exacerbate each other's impact, increasing the risk of chronic diseases mortality. This dual condition is termed "sarcopenic obesity." The correlation between oxidative stress (OS) sarcopenia or obesity was established, balance score (OBS) can serve as an indicator overall dietary lifestyle-related OS exposure within individual. Prior reports have not addressed relationship OBS sarcopenic in adults under 60. study endeavors to explore these associations identify potential lifestyle factors. We performed a cross-sectional analysis utilizing data from 4,241 participants National Health Nutrition Examination Survey (NHANES) 2011 2018. cumulative derived 16 components 4 components, where higher scores indicate greater antioxidants lower pro-oxidant factors, reflecting reduced burden. Weighted multivariate logistic regression employed investigate association obesity. Further subgroup analyses conducted examine interactions with various covariates. least absolute shrinkage selection operator (LASSO) applied significant associated which were subsequently integrated into prediction nomogram model. model's predictive accuracy evaluated using receiver operating characteristic (ROC) curve. After adjusting for confounders, weighted demonstrated negative prevalence (odds ratio [OR] = 0.954, 95% confidence interval [CI] 0.925–0.984, P 0.004) (OR 0.948, CI 0.918–0.980, 0.002). models, informed by key identified through LASSO regression, exhibited considerable value (area ROC curve [AUC] 0.813, 0.792–0.833) (AUC 0.894, 0.879–0.909). reveals robust inverse both aged 20–59. These results suggest that antioxidant-rich diet healthy practices, including low-fat diets, adequate vitamin B intake, regular physical activity, weight management, may help mitigate research warranted confirm determine causality.

Language: Английский

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Association between sarcopenia and the prevalence of gallstone in US adults: a cross-sectional analysis of NHANES

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 29, 2025

Gallstones are a common disease that imposes significant burden on public health resources. Sarcopenia is an age-related condition characterized by decline in muscle mass, strength, and function. However, its relationship with gallstones remains unclear. This cross-sectional study included 2,167 US adults from the National Health Nutrition Examination Survey. We used multivariable logistic regression models restricted cubic spline to assess between sarcopenia gallstones. Additionally, subgroup analyses propensity score matching (PSM) were conducted account for potential confounding factors. found negative association index prevalence of (OR: 0.253, 95% CI: 0.132-0.471, P < 0.001). In Model 4, which integrated all covariates, was associated approximately 100% increased compared non-sarcopenia patients 1.995, 1.340-2.948, The results PSM also confirmed 1.982, 1.217-3.285, = 0.007). Notably, this more pronounced subgroups including females, non-Hispanic whites, married individuals, higher education level. summary, our findings suggest positive adults. suggests we should increase emphasis gallstone screening patients. finding needs be validated through further large-scale prospective studies.

Language: Английский

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The association between Dietary Index for Gut Microbiota and sarcopenia: the mediating role of Dietary Inflammatory Index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Background Given the global changes in environmental and dietary habits, understanding potential impact of factors diet-related inflammation on skeletal muscle diseases, including sarcopenia, is crucial. Investigating these relationships can aid development more effective prevention strategies. This study used Dietary Index for Gut Microbiota (DI-GM) Inflammatory (DII) as variables. DI-GM a scoring system to assess influence diet health. Additionally, DII quantifies inflammatory diet. explores association between sarcopenia evaluates whether moderates this relationship. Methods conducted cross-sectional analysis 9,470 participants from 2011–2018 NHANES database. Multivariable logistic regression, restricted cubic splines (RCS), subgroup were employed examine prevalence sarcopenia. mediation was performed investigate associations DII, DI-GM, Results A total included study, whom 823 (7%) had After adjusting all variables using multivariable each one-unit increase associated with 15% decrease (OR = 0.85, 95% CI: 0.77, 0.94), while 28% 1.28, 1.17, 1.41). Furthermore, results remained robust when divided into tertiles. RCS revealed significant linear relationship The also showed that above robust. Mediation 55% mediated by ( P &lt; 0.001). Conclusion Adhering recommendations based may reduce appears mediate relationship, suggesting an anti-inflammatory could offer benefits.

Language: Английский

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Oxidative balance score is independently associated with reduced prevalence of sarcopenia among US adults with metabolic syndrome

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

Background This research seeks to explore the link between oxidative balance score (OBS) and sarcopenia in American adults with Metabolic Syndrome (MetS) using data from a national, population-based survey. Methods The study included 3,625 participants diagnosed Syndrome, all aged 20 years above, derived NHANES datasets spanning 1999–2006 2011–2018. OBS evaluation was based on 16 dietary 4 lifestyle elements. MetS diagnosis followed NCEP-ATP III guidelines, while identification FNIH standards. We employed multivariate logistic regression analyses delve into connections within cohort. Results Sarcopenia found 17.46% of participants. In models adjusted for variables, OBS, each showed significant inverse relationship among individuals [OBS: OR = 0.959, 95%CI: (0.948, 0.982), P trend 0.0005; OBS: 0.963, (0.939, 0.989), 0.0055; 0.860, (0.787, 0.939), 0.0011]. Higher scores were consistently linked decreased incidence (all &lt; 0.05). Restricted cubic spline analysis confirmed that these relationships linear. impact age significant, benefits only observed those 40 older. Conclusions Maintaining diet rich antioxidants is both independently collectively lower occurrence MetS. These results bolster proposition developing OBS-centered preventive strategies patients, particularly

Language: Английский

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Antioxidant Diets and Lifestyles Could Mitigate the Risk of Sarcopenia with Low Muscle Mass in Women: A Retrospective Study

Healthcare, Journal Year: 2025, Volume and Issue: 13(8), P. 910 - 910

Published: April 15, 2025

Background: Sarcopenia is characterized by a loss of muscle mass, strength, and function. At present, there are no effective methods available for prevention or treatment. Oxidative Balance Score (OBS) has been shown to be significantly correlated with decreased risk sarcopenia. Nevertheless, gender-specific studies still exhibit certain limitations. Methods: Individuals who completed dual-energy X-ray absorptiometry the diet lifestyle questionnaires from National Health Nutrition Examination Survey were enrolled. OBSs calculated according dietary variables physical activity. low mass (SLM) was identified based on ratio appendicular skeletal body index. A logistic regression analysis investigated association between OBS SLM in different gender groups. Kaplan–Meier survival subgroup analyses Cox used explore relationship mortality individuals each subgroup. Results: The level group lower (20.40 vs. 17.07, p < 0.05). multivariate showed that OR individual nutrients exhibition gender-specific. Stratified revealed total OBS, as well negatively associated within (all 0.05, all trends Furthermore, restriction cubic spline females (nonlinear = 0.0469, nonlinear 0.0254). KM curve not all-cause male female subgroups (female, 0.064, male, 0.53). Conclusions: This study establishes significant negative correlation SLM, particularly among females. Consequently, adopting an antioxidant may prove more advantageous

Language: Английский

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Association between oxidative balance score and endometriosis findings from NHANES 1999–2006

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Aim The Oxidative Balance Score (OBS) functions as a measure for gauging the oxidative stress condition, OBS has been utilized to assess overall oxidants and antioxidants exposure status in various chronic disease studies, Growing evidence suggests that is involved pathophysiologic mechanisms of endometriosis, purpose this study was investigate association between endometriosis women ages 20 54. Methods Results correlation meticulously examined through multifaceted approach, encompassing multivariate logistic regression, sensitivity analysis, application smoothing techniques curve fitting. This analysis conducted utilizing extensive dataset from National Health Nutrition Examination Survey (NHANES) spanning years 1999 2006. To ascertain stability observed relationship across diverse demographic segments, subgroup interaction tests were implemented. Among 3881 participants aged 54 years, significant inverse identified scores presence endometriosis. Specifically, within comprehensively adjusted model, every 1 score increase OBS, odds prevalence decreased by 2.00%. highest quartile demonstrated 29.1% reduction when compared those lowest quartile, with confidence interval [0.480, 1.048], underscoring robustness trend. Conclusions related among American adults. Our results suggest elevated may potentially reduce prevalence.

Language: Английский

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The association between oxidative balance score and muscular dystrophies

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 13, 2024

This research utilized data from the NHANES 2011-2018 study to investigate connection between Oxidative Balance Score (OBS) and muscular dystrophies.

Language: Английский

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Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

Background Oxidative stress may be relevant in the progression and cardiovascular complications of prediabetes. The oxidative balance score (OBS) is an emerging metric for assessing dietary lifestyle exposure. objective this prospective cohort study from NHANES 1999–2018 was to explore association OBS with all-cause disease (CVD) mortality people Methods composed 16 components 4 based on previous research. Prediabetes diagnosed self-reported history or laboratory criteria. Multivariate Cox proportional hazards regression analyses were used these associations calculate hazard ratios [HR] 95% confidence intervals [CI]. Results A total 8256 adult participants prediabetes included. Kaplan-Meier survival analysis showed significantly higher CVD-related at OBS. After adjusting all confounders, OBS, inversely associated (HR CI 0.959 (0.946,0.973), 0.965 (0.950,0.980), 0.847 (0.798,0.899), respectively; p < 0.0001). Higher lower (p trend Similar results observed CVD mortality. Most linear, whereas nonlinear. Mediation suggested that several systemic inflammatory markers mediated associations. Stratified sensitivity demonstrated stability findings. Conclusions Adherence antioxidant patterns assessed by help prevent excess population These effects achieved indirectly influencing markers.

Language: Английский

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