Influence of Maternal Diet and Lactation Time on the Exosomal miRNA Cargo in Breast Milk DOI Creative Commons

Laura Sanjulián,

Alexandre Lamas, Rocío Barreiro

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1003 - 1003

Published: March 16, 2025

The importance of breastfeeding for maternal and infant health is widely accepted. In this sense, the presence macro micronutrients in human milk ensures proper safe nutrition, along with multiple bioactive molecules that modulate newborn's immunity. Usually packaged within exosomes, miRNAs circulating are bioavailable to breastfed infants. Their role development poorly understood, mainly because miRNA cargo has not been fully elucidated date. objective study assess eleven (miR-148a-3p, miR-29b-3p, miR-125b-5p, miR-200c-3p, let-7f-5p, let-7b-5p, let-7a-5p, miR-92a, miR-181a-3p, miR-30a-5p miR-155-5p) breast exosomes determine impact lactation time factors on their levels. Samples were collected from a cohort 59 Spanish mothers, ranging 1 months lactation. MiRNAs analyzed using reverse transcription qPCR. Lactation showed significant noteworthy downregulation miR-148a-3p, miR-200c-3p miR-125b-5p hsa-let-7a-5p. levels correlated some fatty acids such as arachidonic acid DHA. Also, positive correlation between Se was found, linked upregulated miR-125b. results work demonstrate dynamic, probably aim adapting specific needs infant.

Language: Английский

Human breast milk-derived exosomes and their positive role on neonatal intestinal health DOI

Gen Chen,

Xiangdong Ouyang,

Yue Mu

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Language: Английский

Citations

2
Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding DOI Open Access
Bodo C. Melnik, Ralf Weiskirchen, Wolfgang Stremmel

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2451 - 2451

Published: July 28, 2024

It is the purpose of this review to compare differences in postnatal epigenetic programming at level DNA and RNA methylation later obesity risk between infants receiving artificial formula feeding (FF) contrast natural breastfeeding (BF). FF bears aberrant enhances expression demethylase fat mass- obesity-associated gene (FTO), pointing further deviations methylome. Based on a literature search through Web Science, Google Scholar, PubMed databases concerning dietary factors influencing FTO protein activity, FTO’s impact adipogenic was investigated. Accumulated translational evidence underscores that total intake as well tryptophan, kynurenine, branched-chain amino acids, milk exosomal miRNAs, NADP, NADPH are crucial regulators modifying activity. Increased FTO-mTORC1-S6K1 signaling may epigenetically suppress WNT/β-catenin pathway, enhancing adipocyte precursor cell proliferation adipogenesis. Formula-induced FTO-dependent alterations N6-methyladenosine (m6A) methylome represent novel unfavorable molecular events development adipogenesis obesity, necessitating investigations. BF provides physiological regulation, compelling reason rely BF.

Language: Английский

Citations

3
Influence of Maternal Diet and Lactation Time on the Exosomal miRNA Cargo in Breast Milk DOI Creative Commons

Laura Sanjulián,

Alexandre Lamas, Rocío Barreiro

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1003 - 1003

Published: March 16, 2025

The importance of breastfeeding for maternal and infant health is widely accepted. In this sense, the presence macro micronutrients in human milk ensures proper safe nutrition, along with multiple bioactive molecules that modulate newborn's immunity. Usually packaged within exosomes, miRNAs circulating are bioavailable to breastfed infants. Their role development poorly understood, mainly because miRNA cargo has not been fully elucidated date. objective study assess eleven (miR-148a-3p, miR-29b-3p, miR-125b-5p, miR-200c-3p, let-7f-5p, let-7b-5p, let-7a-5p, miR-92a, miR-181a-3p, miR-30a-5p miR-155-5p) breast exosomes determine impact lactation time factors on their levels. Samples were collected from a cohort 59 Spanish mothers, ranging 1 months lactation. MiRNAs analyzed using reverse transcription qPCR. Lactation showed significant noteworthy downregulation miR-148a-3p, miR-200c-3p miR-125b-5p hsa-let-7a-5p. levels correlated some fatty acids such as arachidonic acid DHA. Also, positive correlation between Se was found, linked upregulated miR-125b. results work demonstrate dynamic, probably aim adapting specific needs infant.

Language: Английский

Citations

0